{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:46:04Z","timestamp":1793371564695,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A1B05049787"],"award-info":[{"award-number":["NRF-2018R1D1A1B05049787"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Lactate is an important organic molecule that is produced in excess during anaerobic metabolism when oxygen is absent in the human organism. The concentration of this substance in the body can be related to several medical conditions, such as hemorrhage, respiratory failure, and ischemia. Herein, we describe a graphene-based lactate biosensor to detect the concentrations of L-lactic acid in different fluids (buffer solution and plasma). The active surface (graphene) of the device was functionalized with lactate dehydrogenase enzyme using different substances (Nafion, chitosan, and glutaraldehyde) to guarantee stability and increase selectivity. The devices presented linear responses for the concentration ranges tested in the different fluids. An interference study was performed using ascorbic acid, uric acid, and glucose, and there was a minimum variation in the Dirac point voltage during detection of lactate in any of the samples. The stability of the devices was verified at up to 50 days while kept in a dry box at room temperature, and device operation was stable until 12 days. This study demonstrated graphene performance to monitor L-lactic acid production in human samples, indicating that this material can be implemented in more simple and low-cost devices, such as flexible sensors, for point-of-care applications.<\/jats:p>","DOI":"10.3390\/s21051852","type":"journal-article","created":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T21:52:15Z","timestamp":1615153935000},"page":"1852","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A Graphene-Based Enzymatic Biosensor Using a Common-Gate Field-Effect Transistor for L-Lactic Acid Detection in Blood Plasma Samples"],"prefix":"10.3390","volume":"21","author":[{"given":"Ariadna","family":"Schuck","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Konzen","family":"Moreira","sequence":"additional","affiliation":[{"name":"Graduate Program in Nursing, Universidade do Vale do Rio dos Sinos, 93022-750 S\u00e3o Leopoldo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Schmidt","family":"Lora","sequence":"additional","affiliation":[{"name":"Graduate Program in Nursing, Universidade do Vale do Rio dos Sinos, 93022-750 S\u00e3o Leopoldo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Sang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bios.2018.06.054","article-title":"Lactate biosensing: The emerging point-of-care and personal health monitoring","volume":"117","author":"Alam","year":"2018","journal-title":"Biosens. 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