{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:10:33Z","timestamp":1793718633977,"version":"4.6.1"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Estatal de Investigaci\u00f3n - Ministerio de Ciencia e Innovaci\u00f3n and European Regional Development Fund","award":["PID2019-107335RA-I00"],"award-info":[{"award-number":["PID2019-107335RA-I00"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n - Ministerio de Ciencia e Innovaci\u00f3n and European Regional Development Fund","award":["PID2019-110430GB-C21"],"award-info":[{"award-number":["PID2019-110430GB-C21"]}]},{"name":"Gobierno Aut\u00f3nomo de Canarias","award":["ProID2020010067"],"award-info":[{"award-number":["ProID2020010067"]}]},{"name":"Gobierno Aut\u00f3nomo de Canarias","award":["2018-00000034"],"award-info":[{"award-number":["2018-00000034"]}]},{"name":"Spanish Ministerio de Econom\u00eda y Competitividad","award":["BFU2016-77363-R"],"award-info":[{"award-number":["BFU2016-77363-R"]}]},{"name":"Spanish Ministerio de Econom\u00eda y Competitividad","award":["PID2019-105795RB-I00"],"award-info":[{"award-number":["PID2019-105795RB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Huntington\u2019s disease (HD) is an autosomal dominant, incurable neurodegenerative disease caused by mutation in the huntingtin gene (HTT). HTT mutation leads to protein misfolding and aggregation, which affect cells\u2019 functions and structural features. Because these changes might modify the scattering strength of affected cells, we propose that random lasing (RL) is an appropriate technique for detecting cells that express mutated HTT. To explore this hypothesis, we used a cell model of HD based on the expression of two different forms\u2014pathogenic and non-pathogenic\u2014of HTT. The RL signals from both cell profiles were compared. A multivariate statistical analysis of the RL signals based on the principal component analysis (PCA) and linear discriminant analysis (LDA) techniques revealed substantial differences between cells that expressed the pathogenic and the non-pathogenic forms of HTT.<\/jats:p>","DOI":"10.3390\/s21113825","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T23:33:33Z","timestamp":1622504013000},"page":"3825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Random Lasing Detection of Mutant Huntingtin Expression in Cells"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2084-3200","authenticated-orcid":false,"given":"Sergio","family":"de Armas-Rillo","sequence":"first","affiliation":[{"name":"Departamento de F\u00edsica, Instituto Universitario de Estudios Avanzados en F\u00edsica At\u00f3mica, Molecular y Fot\u00f3nica (IUdEA), Universidad de La Laguna, 38206 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Fumagallo-Reading","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-9762","authenticated-orcid":false,"given":"Diego","family":"Luis-Ravelo","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-7662","authenticated-orcid":false,"given":"Beatriz","family":"Abdul-Jalbar","sequence":"additional","affiliation":[{"name":"Departamento de Matem\u00e1ticas, Estad\u00edstica e Investigaci\u00f3n Operativa, Universidad de La Laguna, 38206 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Instituto de Tecnolog\u00edas Biom\u00e9dicas (ITB), Universidad de La Laguna, 38320 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Lahoz","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica, Instituto Universitario de Estudios Avanzados en F\u00edsica At\u00f3mica, Molecular y Fot\u00f3nica (IUdEA), Universidad de La Laguna, 38206 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ambartsumyan, R.V., Basov, N.G., Kryukov, P.G., and Letokhov, V.S. 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