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They have become powerful analysis tools in trace detection with ultra-low detection limits and extremely high accuracy, resulting in their great popularity in medical detection, environmental inspection, and other applications. Herein, we summarize and generalize the recently reported paper-based sensors based on their application for mechanics, biomolecules, food safety, and environmental inspection. Based on the biological, physical, and chemical analytes-sensitive electrical or optical signals, extensive detections of a large number of factors such as humidity, pressure, nucleic acid, protein, sugar, biomarkers, metal ions, and organic\/inorganic chemical substances have been reported via paper-based sensors. Challenges faced by the current paper-based sensors from the fundamental problems and practical applications are subsequently analyzed; thus, the future directions of paper-based sensors are specified for their rapid handheld testing.<\/jats:p>","DOI":"10.3390\/s21185998","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T02:41:07Z","timestamp":1631068867000},"page":"5998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hospitals and Laboratories on Paper-Based Sensors: A Mini Review"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-493X","authenticated-orcid":false,"given":"Huaizu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-5400","authenticated-orcid":false,"given":"Chengbin","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130393","DOI":"10.1016\/j.chemosphere.2021.130393","article-title":"Recent advances in developing optical and elec-trochemical sensors for analysis of methamphetamine: A review","volume":"278","author":"Khorablou","year":"2021","journal-title":"Chemosphere"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1109\/JSEN.2021.3057222","article-title":"Biomedical Catheters with Integrated Miniature Piezoresistive Pressure Sensors: A Review","volume":"21","author":"Meena","year":"2021","journal-title":"IEEE Sens. 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