{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:45:06Z","timestamp":1790671506779,"version":"4.1.0"},"reference-count":44,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Acne is a dermatosis that affects almost 90% of the adolescent population worldwide and its treatment is performed with retinoids, antimicrobials, acids, and topical or systemic antibiotics. Side effects such as skin irritation in addition to microbial resistance to antibiotics are the main side effects found. Phototherapy with blue light is being used as an alternative treatment. Our objective was to analyze the use of blue light to treat inflammatory acne. We conducted a systematic literature review, following the recommendation PRISMA (Preferred Reporting Items for Systematic Reviews and MetaAnalyses), including in the sample randomized clinical trial studies that compared blue light with another intervention as control. The research was carried out in the PUBMED and WEB of SCIENCE databases and the methodological quality of the studies evaluated were made by the Cochrane Collaboration Bias Risk Scale. After the exclusion of duplicates, the titles and abstracts of 81 articles were evaluated, and 50 articles were selected for full reading, including in the review at the end 8 articles. Studies have shown significant improvements in the overall picture of acne. It is concluded that despite the great potential in its use in the treatment of acne, there is a need for more detailed trials on the effect of blue light on the treatment of inflammatory acne.<\/jats:p>","DOI":"10.3390\/s21206943","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:31:26Z","timestamp":1634765486000},"page":"6943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Effect of Blue Light on Acne Vulgaris: A Systematic Review"],"prefix":"10.3390","volume":"21","author":[{"given":"Mara L\u00facia Gon\u00e7alves","family":"Diogo","sequence":"first","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita Molinos","family":"Campos","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa Susana Reis","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Physics Department Covilh\u00e3, Universidade da Beira Interior, 6200-354 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pavani","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina Ratto Tempestini","family":"Horliana","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-9286","authenticated-orcid":false,"given":"Kristianne Porta Santos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Kalil","family":"Bussadori","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca Goreth Malheiro Moraes","family":"Fantin","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Universidade Brasil, S\u00e3o Paulo 08230-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Portes Vieira","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Universidade Brasil, S\u00e3o Paulo 08230-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngela Toshie Araki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Dentistry Department, Universidade Cruzeiro do Sul, S\u00e3o Paulo 01311-925, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Scarparo","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Universidade Brasil, S\u00e3o Paulo 08230-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Jansiski","family":"Motta","sequence":"additional","affiliation":[{"name":"Biophotonics Applied to Health Sciences Department, Nove de Julho University (UNINOVE), Vergueiro 245, S\u00e3o Paulo 01504-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sociedade Brasileira de Dermatologia (2006). 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