{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T18:55:16Z","timestamp":1786474516072,"version":"build-2736575974"},"reference-count":97,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:00:00Z","timestamp":1646438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>In patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF), three months of optimal therapy are recommended before considering a primary preventive implantable cardioverter-defibrillator (ICD). It is unclear which patients benefit from a prolonged waiting period under protection of the wearable cardioverter-defibrillator (WCD) to avoid unnecessary ICD implantations. This study included all patients receiving a WCD for newly diagnosed HFrEF (n = 353) at our center between 2012 and 2017. Median follow-up was 2.7 years. From baseline until three months, LVEF improved in patients with all peripartum cardiomyopathy (PPCM), myocarditis, dilated cardiomyopathy (DCM), or ischemic cardiomyopathy (ICM). Beyond this time, LVEF improved in PPCM and DCM only (10 \u00b1 8% and 10 \u00b1 12%, respectively), whereas patients with ICM showed no further improvement. The patients with newly diagnosed HFrEF were compared to 29 patients with a distinct WCD indication, which is an explantation of an infected ICD. This latter group had a higher incidence of WCD shocks and poorer overall survival. All-cause mortality should be considered when deciding on WCD prescription. In patients with newly diagnosed HFrEF, the potential for delayed LVEF recovery should be considered when timing ICD implantation, especially in patients with PPCM and DCM.<\/jats:p>","DOI":"10.3390\/s22052037","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:40:02Z","timestamp":1646599202000},"page":"2037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Delayed Improvement of Left Ventricular Function in Newly Diagnosed Heart Failure Depends on Etiology\u2014A PROLONG-II Substudy"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-7657","authenticated-orcid":false,"given":"Johanna","family":"Mueller-Leisse","sequence":"first","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Brunn","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Zormpas","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1606-3423","authenticated-orcid":false,"given":"Stephan","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike Aenne Katrin","family":"Hillmann","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Eiringhaus","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Veltmann","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-6338","authenticated-orcid":false,"given":"David","family":"Duncker","sequence":"additional","affiliation":[{"name":"Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ejheart.2008.09.004","article-title":"Mode of death in patients with newly diagnosed heart failure in the general population","volume":"10","author":"Mehta","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/clc.22706","article-title":"Ventricular arrhythmias in patients with newly diagnosed nonischemic cardiomyopathy: Insights from the PROLONG study","volume":"40","author":"Duncker","year":"2017","journal-title":"Clin. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1540-8167.2009.01696.x","article-title":"Optimal Timing of Implantable Cardioverter-Defibrillator Implantation After Myocardial Infarction: A Decision Analysis","volume":"21","author":"Piccini","year":"2010","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.hrthm.2006.01.012","article-title":"Equivalent arrhythmic risk in patients recently diagnosed with dilated cardiomyopathy compared with patients diagnosed for 9 months or more","volume":"3","author":"Makati","year":"2006","journal-title":"Heart Rhythm"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"l223","DOI":"10.1136\/bmj.l223","article-title":"Trends in survival after a diagnosis of heart failure in the United Kingdom 2000\u20132017: Population based cohort study","volume":"364","author":"Taylor","year":"2019","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/ejhf.1569","article-title":"Trends in modes of death in heart failure over the last two decades: Less sudden death but cancer deaths on the rise","volume":"21","author":"Moliner","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1056\/NEJMoa1609758","article-title":"Declining Risk of Sudden Death in Heart Failure","volume":"377","author":"Shen","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/heartjnl-2017-311638","article-title":"Long-term complications, reoperations and survival following cardioverter-defibrillator implant","volume":"104","author":"Hawkins","year":"2017","journal-title":"Heart"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e000198","DOI":"10.1136\/openhrt-2014-000198","article-title":"A systematic review of ICD complications in randomised controlled trials versus registries: Is our \u2018real-world\u2019 data an underestimation?","volume":"2","author":"Lee","year":"2015","journal-title":"Open Heart"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e007691","DOI":"10.1161\/JAHA.117.007691","article-title":"Risk Factors and Temporal Trends of Complications Associated With Transvenous Implantable Cardiac Defibrillator Leads","volume":"7","author":"Koneru","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jama.2010.1915","article-title":"Non\u2013Evidence-Based ICD Implantations in the United States","volume":"305","author":"Hellkamp","year":"2011","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/JAHA.116.004512","article-title":"Avoiding Untimely Implantable Cardiovert-er\/Defibrillator Implantation by Intensified Heart Failure Therapy Optimization Supported by the Wearable Cardiovert-er\/Defibrillator-The PROLONG Study","volume":"6","author":"Duncker","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e004478","DOI":"10.1161\/CIRCHEARTFAILURE.117.004478","article-title":"Waiting Period before Implantable Cardioverter-Defibrillator Im-plantation in Newly Diagnosed Heart Failure with Reduced Ejection Fraction: A Window of Opportunity","volume":"10","author":"DeFilippis","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cjca.2021.01.024","article-title":"The Optimal Timing of Primary Prevention Implantable Cardiovert-er-Defibrillator Referral in the Rapidly Changing Medical Landscape","volume":"37","author":"Wong","year":"2021","journal-title":"Can. J.Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.jacc.2013.12.021","article-title":"Sudden cardiac death risk stratification in patients with nonischemic dilated cardiomyopathy","volume":"63","author":"Goldberger","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s11897-018-0415-7","article-title":"Role of the Wearable Defibrillator in Newly Diagnosed Heart Failure","volume":"15","author":"Duncker","year":"2018","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_18","unstructured":"Duncker, D., and Veltmann, C. (2016). The Wearable Cardioverter\/Defibrillator\u2014Toy or Tool?. J. Atr. Fibrillation, 8."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00399-018-0601-z","article-title":"Wearable defibrillator: Current evidence","volume":"29","author":"Duncker","year":"2018","journal-title":"Herzschrittmacherther Elektrophysiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1056\/NEJMoa1800781","article-title":"Wear-able Cardioverter-Defibrillator after Myocardial Infarction","volume":"379","author":"Olgin","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.hroo.2020.07.002","article-title":"The wearable cardioverter-defibrillator is not needed for most high-risk patients","volume":"1","author":"Bhatt","year":"2020","journal-title":"Heart Rhythm O2"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100395","DOI":"10.1016\/j.cpcardiol.2018.09.002","article-title":"Misunderstood or Mistrusted? The Under-Utilization of the Wearable Cardioverter Defibrillator in Clinical Practice","volume":"45","author":"Jagadish","year":"2018","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5142","DOI":"10.1002\/ehf2.13586","article-title":"Extended follow-up after wearable cardioverter-defibrillator period: The PROLONG-II study","volume":"8","author":"Brunn","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jacep.2016.09.002","article-title":"Benefit of the Wearable Cardioverter-Defibrillator in Protecting Patients after Implantable-Cardioverter Defibrillator Explant: Results from the Na-tional Registry","volume":"3","author":"Ellenbogen","year":"2017","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1111\/jce.14153","article-title":"Potential cost-effectiveness of wearable cardioverter-defibrillator for patients with implantable cardioverter-defibrillator explant in a high-income city of China","volume":"30","author":"Jiang","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2018.08.017","article-title":"Long-term use of the wearable car-dioverter defibrillator in patients with explanted ICD","volume":"272","author":"Kaspar","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jacep.2016.10.015","article-title":"Mitigating Post-Extraction Risk: Is it Worth the inVESTment?","volume":"3","author":"Chung","year":"2017","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1136\/hrt.2008.156034","article-title":"Improving survival in the 6 months after diagnosis of heart failure in the past decade: Population-based data from the UK","volume":"95","author":"Dubrey","year":"2009","journal-title":"Heart"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMoa1608029","article-title":"DANISH Investigators, Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure","volume":"375","author":"Thune","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/eurheartj\/ehy344","article-title":"Primary prevention implantable cardioverter-defibrillator and opportunities for sudden cardiac death risk assessment in non-ischaemic cardiomyopathy","volume":"39","author":"Pathak","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cardfail.2011.09.004","article-title":"Characteristics and outcomes of peripartum versus nonperipar-tum cardiomyopathy in women using a wearable cardiac defibrillator","volume":"18","author":"Saltzberg","year":"2012","journal-title":"J. Card. Fail."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/joa3.12017","article-title":"Implantable cardioverter defib-rillator in nonischemic cardiomyopathy: A systematic review and meta-analysis","volume":"34","author":"Khan","year":"2018","journal-title":"J. Arrhythmia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jacc.2015.12.042","article-title":"PREDICTS Investigators, Predicting Persistent Left Ventricular Dysfunction Following Myocardial Infarction: The PREDICTS Study","volume":"67","author":"GBrooks","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.114.009924","article-title":"Evolution of left ventricular ejection fraction after acute myocardial infarction: Implications for implantable cardioverter-defibrillator eligibility","volume":"130","author":"Muhrbeck","year":"2014","journal-title":"Circulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","article-title":"Novel Predictors of Left Ventricular Reverse Remodeling in Individuals With Recent-Onset Dilated Cardiomyopathy","volume":"61","author":"Kubanek","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1062-1458(02)00940-6","article-title":"Prognosis and determinants of survival in patients newly hospitalized for heart failure","volume":"11","author":"Jong","year":"2002","journal-title":"A Popul.-Based Study. ACC Curr. J. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10741-012-9306-2","article-title":"Renal dysfunction in acute and chronic heart failure: Prevalence, incidence and prognosis","volume":"17","author":"Cleland","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.amjcard.2017.05.014","article-title":"Diabetes Mellitus and Heart Failure","volume":"120","author":"Lehrke","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.hfc.2013.12.004","article-title":"Arterial Hypertension in Patients with Heart Failure","volume":"10","year":"2014","journal-title":"Heart Fail. Clin."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/CIRCRESAHA.120.317883","article-title":"Lipid Profiles and Heart Failure Risk: Results From Two Prospective Studies","volume":"128","author":"Wittenbecher","year":"2021","journal-title":"Circ. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"iii14","DOI":"10.1136\/hrt.2005.070342","article-title":"Gender and heart failure: A population perspective","volume":"92","author":"Mehta","year":"2006","journal-title":"Heart"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/ejhf.1493","article-title":"Pathophysiology, diagnosis and management of peri-partum cardiomyopathy: A position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy","volume":"21","author":"Bauersachs","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00059-018-4709-z","article-title":"Peripartum cardiomyopathy","volume":"43","author":"Sliwa","year":"2018","journal-title":"Herz"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jchf.2019.02.015","article-title":"Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF","volume":"7","author":"Balmforth","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s00059-020-04903-5","article-title":"Dilated cardiomyopathies and non-compaction car-diomyopathy","volume":"45","author":"Veltmann","year":"2020","journal-title":"Herz"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1161\/CIRCULATIONAHA.108.769489","article-title":"Predictors of outcome in patients with suspected myocarditis","volume":"118","author":"Kindermann","year":"2008","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e011492","DOI":"10.1161\/CIRCIMAGING.120.011492","article-title":"Prognostic Impact of Late Gadolinium Enhancement by Cardiovascular Magnetic Resonance in Myocarditis: A Systematic Review and Meta-Analysis","volume":"14","author":"Georgiopoulos","year":"2021","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.jacc.2012.01.007","article-title":"Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis: Predictors of Mortality and Incomplete Recovery","volume":"59","author":"Schumm","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1002\/ehf2.13353","article-title":"Benefit of a wearable cardioverter defibrillator for detection and therapy of arrhythmias in pa-tients with myocarditis","volume":"8","author":"Tscholl","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.jacc.2017.08.050","article-title":"Prognostic Value of Cardiac Magnetic Resonance Tissue Characterization in Risk Stratifying Patients With Suspected Myocarditis","volume":"70","author":"Eichhorn","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jcmg.2014.01.015","article-title":"Influence of vegetation size on the clinical presentation and outcome of lead-associated endocarditis: Results from the MEDIC registry","volume":"7","author":"Greenspon","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/europace\/euu147","article-title":"Risk factors for 1-year mortality among patients with cardiac implantable electronic device infection undergoing transvenous lead extraction: The impact of the infec-tion type and the presence of vegetation on survival","volume":"16","author":"Tarakji","year":"2014","journal-title":"Europace"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13019-017-0669-2","article-title":"The wearable cardioverter defibrillator as a bridge to reimplantation in patients with ICD or CRT-D-related infections","volume":"12","author":"Castro","year":"2017","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.jtcvs.2010.11.059","article-title":"Complete removal as a routine treatment for any cardiovascular implantable electronic device\u2013associated infection","volume":"142","author":"Pichlmaier","year":"2011","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jacc.2009.11.034","article-title":"Percutaneous Pacemaker and Implantable Cardioverter-Defibrillator Lead Extraction in 100 Patients With Intracardiac Vegetations Defined by Transesophageal Echocardiogram","volume":"55","author":"Grammes","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus en-alapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/CIRCULATIONAHA.110.000646","article-title":"Left ventricular lead position and clinical outcome in the multicenter au-tomatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT) trial","volume":"123","author":"Singh","year":"2011","journal-title":"Circulation"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e015042","DOI":"10.1161\/JAHA.119.015042","article-title":"Real-World Analysis of Guideline-Based Therapy After Hospitalization for Heart Failure","volume":"9","author":"Wirtz","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jce.14404","article-title":"Impact of wearable cardioverter-defibrillator compliance on outcomes in the VEST trial: As-treated and per-protocol analyses","volume":"31","author":"Olgin","year":"2020","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lyratzopoulos, G., A Cook, G., McElduff, P., Havely, D., Edwards, R., and Heller, R.F. (2004). Assessing the impact of heart failure specialist services on patient populations. BMC Health Serv. Res., 4.","DOI":"10.1186\/1472-6963-4-10"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/heartjnl-2012-302313","article-title":"Specialist clinics for reducing emergency admissions in patients with heart failure: A systematic review and meta-analysis of randomised controlled trials","volume":"99","author":"Thomas","year":"2013","journal-title":"Heart"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/01.CIR.0000151811.53450.B8","article-title":"Discharge Education Improves Clinical Outcomes in Patients With Chronic Heart Failure","volume":"111","author":"Koelling","year":"2005","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ehjcvp\/pvaa125","article-title":"Different left ventricular remodeling patterns and clinical outcomes between non-ischemic and ischemic etiologies in heart failure patients receiving sacubitril\/valsartan treatment","volume":"8","author":"Lee","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Pharm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.hrthm.2016.04.013","article-title":"Associations be-tween scar characteristics by cardiac magnetic resonance and changes in left ventricular ejection fraction in primary preven-tion defibrillator recipients","volume":"13","author":"Zhang","year":"2016","journal-title":"Heart Rhythm"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ehf2.12624","article-title":"Association between heart failure aetiology and magnitude of echocardiographic re-modelling and outcome of cardiac resynchronization therapy","volume":"7","author":"Kloosterman","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/CIRCULATIONAHA.117.026386","article-title":"Survival and Left Ventricular Function Changes in Fulminant Versus Nonfulminant Acute Myocarditis","volume":"136","author":"Ammirati","year":"2017","journal-title":"Circulation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1161\/CIRCRESAHA.118.313578","article-title":"Management of Myocarditis-Related Cardiomyo-pathy in Adults","volume":"124","author":"Cooper","year":"2019","journal-title":"Circ. Res."},{"key":"ref_68","first-page":"169","article-title":"Myocarditis and inflammatory cardiomyopathy: Current evidence and future directions","volume":"18","author":"Ammirati","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.autrev.2007.11.010","article-title":"Genetic complexity of autoimmune myocarditis","volume":"7","author":"Li","year":"2008","journal-title":"Autoimmun. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.2015.15734","article-title":"Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial","volume":"314","author":"Gheorghiade","year":"2015","journal-title":"JAMA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ejheart.2007.04.003","article-title":"Advanced chronic heart failure: A position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology","volume":"9","author":"Metra","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/clc.22024","article-title":"Identification of High-Risk Chronic Heart Failure Patients in Clinical Practice: Role of Changes in Left Ventricular Function","volume":"35","author":"Cicoira","year":"2012","journal-title":"Clin. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1016\/j.jacc.2017.04.043","article-title":"Hospitalization for Re-cently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial","volume":"69","author":"Greene","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.amjcard.2019.05.031","article-title":"Differences in Mortality of New-Onset (De-Novo) Acute Heart Failure Versus Acute Decompensated Chronic Heart Failure","volume":"124","author":"Younis","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/ejhf.188","article-title":"Risk for ventricular fibrillation in peripartum cardiomyopathy with severely reduced left ventricular function-value of the wearable cardioverter\/defibrillator","volume":"16","author":"Duncker","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/ejhf.1178","article-title":"Long-term prognosis, subsequent pregnancy, contraception and overall management of peripartum car-diomyopathy: Practical guidance paper from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy","volume":"20","author":"Sliwa","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/hrt.2008.150656","article-title":"Device complications and inappropriate implantable cardioverter defibrillator shocks in patients with hypertrophic cardiomyopathy","volume":"95","author":"Lin","year":"2009","journal-title":"Heart"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pcad.2008.10.001","article-title":"Risks and Challenges of Implantable Cardioverter-Defibrillators in Young Adults","volume":"51","author":"Sherrid","year":"2008","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.hrthm.2015.03.061","article-title":"Wearable cardioverter-defibrillator for prevention of sudden cardiac death after in-fected implantable cardioverter-defibrillator removal: A cost-effectiveness evaluation","volume":"12","author":"Healy","year":"2015","journal-title":"Heart Rhythm"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcha.2015.01.015","article-title":"Etiology-specific assessment of predictors of long-term survival in chronic systolic heart failure","volume":"7","author":"Franke","year":"2015","journal-title":"IJC Heart Vasc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.hrthm.2011.05.015","article-title":"Impact of timing of device removal on mortality in patients with cardiovascular implantable electronic device infections","volume":"8","author":"Le","year":"2011","journal-title":"Heart Rhythm"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/CIRCEP.111.965277","article-title":"Long-Term Mortality After Transvenous Lead Extraction","volume":"5","author":"Maytin","year":"2012","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa043399","article-title":"Amiodarone or an Implantable Cardioverter\u2013Defibrillator for Congestive Heart Failure","volume":"352","author":"Bardy","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1056\/NEJM199612263352601","article-title":"Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia","volume":"335","author":"Moss","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa013474","article-title":"Multicenter Automatic Defibrillator Implantation Trial II Investigators, Prophylactic implantation of a defibril-lator in patients with myocardial infarction and reduced ejection fraction","volume":"346","author":"Moss","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1056\/NEJMoa041489","article-title":"Prophylactic Use of an Implantable Cardioverter\u2013Defibrillator after Acute Myocardial Infarction","volume":"351","author":"Hohnloser","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1056\/NEJMoa033088","article-title":"Prophylactic Defibrillator Implantation in Patients with Nonischemic Dilated Cardiomyopathy","volume":"350","author":"Kadish","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e018063","DOI":"10.1161\/JAHA.120.018063","article-title":"DO-IT Registry Investigators, Dutch Outcome in Implantable Cardioverter-Defibrillator Therapy: Implantable Cardiovert-er-Defibrillator-Related Complications in a Contemporary Primary Prevention Cohort","volume":"10","author":"Verstraelen","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/clc.22496","article-title":"Gender, Racial, and Health Insurance Differences in the Trend of Implantable Cardiovert-er-Defibrillator (ICD) Utilization: A United States Experience Over the Last Decade","volume":"39","author":"Patel","year":"2016","journal-title":"Clin. Cardiol."},{"key":"ref_90","first-page":"971","article-title":"Spanish Implantable Cardioverter-defibrillator Registry. 17th Official Report of the Heart Rhythm Association of the Spanish Society of Cardiology (2020)","volume":"74","author":"Lozano","year":"2021","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/ejhf.586","article-title":"Current management of patients with severe acute peripartum cardiomyopathy: Practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy","volume":"18","author":"Bauersachs","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.19102\/icrm.2019.100804","article-title":"Mortality and Costs Associated with Wearable Cardiovert-er-defibrillators after Acute Myocardial Infarction: A Retrospective Cohort Analysis of Medicare Claims Data","volume":"10","author":"Clark","year":"2019","journal-title":"J. Innov. Card Rhythm Manag."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.3310\/hta10270","article-title":"A review of the evi-dence on the effects and costs of implantable cardioverter defibrillator therapy in different patient groups, and modelling of cost-effectiveness and cost-utility for these groups in a UK context","volume":"10","author":"Buxton","year":"2006","journal-title":"Health Technol. Assess"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jval.2011.02.1180","article-title":"Cost-effectiveness of implantable defibrillators after myocardial infarction based on 8-year follow-up data (MADIT II)","volume":"14","author":"Gandjour","year":"2011","journal-title":"Value Health"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.hrthm.2009.05.020","article-title":"Heart Rhythm Society, American Heart Association, Transvenous lead extraction: Heart Rhythm Society expert consensus on facilities, training, indications, and patient man-agement: This document was endorsed by the American Heart Association (AHA)","volume":"6","author":"Wilkoff","year":"2009","journal-title":"Heart Rhythm"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/europace\/euw180","article-title":"The wearable cardioverter-defibrillator: Current technology and evolving indications","volume":"19","author":"Reek","year":"2016","journal-title":"Europace"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/clc.23709","article-title":"Cost-minimization analysis of a wearable cardioverter defibrillator in adult patients un-dergoing ICD explant procedures: Clinical and economic implications","volume":"44","author":"Boriani","year":"2021","journal-title":"Clin. Cardiol."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/5\/2037\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:32:33Z","timestamp":1760135553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/5\/2037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,5]]},"references-count":97,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["s22052037"],"URL":"https:\/\/doi.org\/10.3390\/s22052037","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,5]]}}}