{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:40:20Z","timestamp":1769388020845,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CAP-18014-000"],"award-info":[{"award-number":["CAP-18014-000"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Ministry of Science and ICT, the Ministry of Trade, Industry and 263 Energy, the Ministry of Health &amp; Welfare, the Ministry of Food and Drug Safety","award":["1711138169, 264 KMDF KMDF_PR_20200901_0100"],"award-info":[{"award-number":["1711138169, 264 KMDF KMDF_PR_20200901_0100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Heart rate variability (HRV) is closely related to changes in the autonomic nervous system (ANS) associated with stress and pain. In this study, we investigated whether HRV could be used to assess cancer pain in mice with peritoneal metastases. At 12 days after cancer induction, positive indicators of pain such as physiological characteristics, appearance, posture, and activity were observed, and time- and frequency-domain HRV parameters such as mean R-R interval, square root of the mean squared differences of successive R-R intervals, and percentage of successive R-R interval differences greater than 5 ms, low frequency (LF), high frequency (HF), and ratio of LF and HF power, were found to be significantly decreased. These parameters returned to normal after analgesic administration. Our results indicate that overall ANS activity was decreased by cancer pain and that HRV could be a useful tool for assessing pain.<\/jats:p>","DOI":"10.3390\/s22062152","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:19:10Z","timestamp":1646943550000},"page":"2152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Heart Rate Variability as a Potential Indicator of Cancer Pain in a Mouse Model of Peritoneal Metastasis"],"prefix":"10.3390","volume":"22","author":[{"given":"Yurim","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-3633","authenticated-orcid":false,"given":"Hong Yeol","family":"Yoon","sequence":"additional","affiliation":[{"name":"Biomedical Research Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02791, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Keun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea"},{"name":"Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inchan","family":"Youn","sequence":"additional","affiliation":[{"name":"Biomedical Research Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02791, Korea"},{"name":"Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-668X","authenticated-orcid":false,"given":"Sungmin","family":"Han","sequence":"additional","affiliation":[{"name":"Biomedical Research Division, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02791, Korea"},{"name":"Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/535S1a","article-title":"Pain","volume":"535","author":"Grayson","year":"2016","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3322\/caac.20112","article-title":"The Management of Cancer Pain","volume":"61","author":"Paice","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00844431","article-title":"Chronic back pain and rheumatoid arthritis: Predicting pain and disability from cognitive variables","volume":"11","author":"Flor","year":"1988","journal-title":"J. Behav. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/ar3306","article-title":"The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/EJA.0b013e328343d524","article-title":"The influence of age and sex on the relationship between heart rate variability, haemodynamic variables and subjective measures of acute post-operative pain","volume":"28","author":"Ledowski","year":"2011","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jpainsymman.2018.09.016","article-title":"Heart Rate Variability as an Indicator of Nociceptive Pain in Disorders of Consciousness?","volume":"57","author":"Riganello","year":"2019","journal-title":"J. Pain Symptom. Manag."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.biopsycho.2007.10.004","article-title":"Heart rate variability and pain: Associations of two interrelated homeostatic processes","volume":"77","author":"Appelhans","year":"2008","journal-title":"Biol. Psychol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Arras, M., Rettich, A., Cinelli, P., Kasermann, H.P., and Burki, K. (2007). Assessment of post-laparotomy pain in laboratory mice by telemetric recording of heart rate and heart rate variability. BMC Vet. Res., 3.","DOI":"10.1186\/1746-6148-3-16"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.physbeh.2011.07.004","article-title":"Poincare plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats","volume":"104","author":"Charlet","year":"2011","journal-title":"Physiol. Behav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.pain.2007.05.020","article-title":"Changes in cardiovascular parameters and plasma norepinephrine level in rats after chronic constriction injury on the sciatic nerve","volume":"135","author":"Jin","year":"2008","journal-title":"Pain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/EJA.0000000000000304","article-title":"Monitoring heart rate variability to assess experimentally induced pain using the analgesia nociception index A randomised volunteer study","volume":"33","author":"Jess","year":"2016","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De Jonckheere, J., Logier, R., Jounwaz, R., Vidal, R., and Jeanne, M. (September, January 31). From pain to stress evaluation using heart rate variability analysis: Development of an evaluation platform. Proceedings of the 2010 Annual International Conference of the Ieee Engineering in Medicine and Biology Society (Embc), Buenos Aires, Argentina.","DOI":"10.1109\/IEMBS.2010.5627661"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/ALN.0000000000001670","article-title":"Validation of Innovative Techniques for Monitoring Nociception during General Anesthesia A Clinical Study Using Tetanic and Intracutaneous Electrical Stimulation","volume":"127","author":"Funcke","year":"2017","journal-title":"Anesthesiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/AJP.0b013e3181ed1058","article-title":"Newborn Infant Pain Assessment Using Heart Rate Variability Analysis","volume":"26","author":"Faye","year":"2010","journal-title":"Clin. J. Pain"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10484-011-9147-0","article-title":"Effects of heart rate variability biofeedback in subjects with stress-related chronic neck pain: A pilot study","volume":"36","author":"Hallman","year":"2011","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_16","first-page":"39","article-title":"Spiral Steel Wire Based Fiber-Shaped Stretchable and Tailorable Triboelectric Nanogenerator for Wearable Power Source and Active Gesture Sensor","volume":"11","author":"Xie","year":"2019","journal-title":"Nanomicro Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bspc.2014.01.011","article-title":"Matlab-based tool for ECG and HRV analysis","volume":"10","author":"Mali","year":"2014","journal-title":"Biomed. Signal Process. Control."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12012-007-0004-6","article-title":"Heart rate variability in rodents: Uses and caveats in toxicological studies","volume":"7","author":"Rowan","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1109\/TBME.1985.325532","article-title":"A Real-Time Qrs Detection Algorithm","volume":"32","author":"Pan","year":"1985","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_20","first-page":"411","article-title":"Efficacy of Tramadol as a Sole Analgesic for Postoperative Pain in Male and Female Mice","volume":"54","author":"Wolfe","year":"2015","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/j.pain.0000000000000360","article-title":"Meta-analytic evidence for decreased heart rate variability in chronic pain implicating parasympathetic nervous system dysregulation","volume":"157","author":"Tracy","year":"2016","journal-title":"Pain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/S0140-6736(11)60236-5","article-title":"Treatment of cancer pain","volume":"377","author":"Portenoy","year":"2011","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1534735418756192","article-title":"Heart Rate Variability as a Marker of Distress and Recovery: The Effect of Brief Supportive Expressive Group Therapy With Mindfulness in Cancer Patients","volume":"17","author":"Park","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_24","first-page":"449","article-title":"Heart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children","volume":"6","author":"Evans","year":"2013","journal-title":"J. Pain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jmpt.2010.03.012","article-title":"Heart Rate Variability Modulation after Manipulation in Pain-Free Patients Vs Patients in Pain Reply","volume":"33","author":"Roy","year":"2010","journal-title":"J. Manip. Physiol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/laban0311-85","article-title":"Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy","volume":"40","author":"Kissling","year":"2011","journal-title":"Lab. Anim."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/pme.12133","article-title":"Heart rate variability parameters do not correlate with pain intensity in healthy volunteers","volume":"14","author":"Meeuse","year":"2013","journal-title":"Pain Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e13287","DOI":"10.1111\/psyp.13287","article-title":"Should heart rate variability be \u201ccorrected\u201d for heart rate? Biological, quantitative, and interpretive considerations","volume":"56","author":"Gianaros","year":"2019","journal-title":"Psychophysiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1088\/0967-3334\/27\/10\/005","article-title":"Dependence of heart rate variability on heart period in disease and aging","volume":"27","author":"Platisa","year":"2006","journal-title":"Physiol. Meas."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1177\/1932296814545669","article-title":"A novel quantitative method for diabetic cardiac autonomic neuropathy assessment in type 1 diabetic mice","volume":"8","author":"Chon","year":"2014","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","article-title":"An Overview of Heart Rate Variability Metrics and Norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front Public Health"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/6\/2152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:34:15Z","timestamp":1760135655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/6\/2152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["s22062152"],"URL":"https:\/\/doi.org\/10.3390\/s22062152","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,10]]}}}