{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:19:28Z","timestamp":1792815568305,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Finnish Foundation for Cardiovascular Research","award":["1788\/31\/2019"],"award-info":[{"award-number":["1788\/31\/2019"]}]},{"name":"Clinical Research Fund (EVO) of Turku University Hospital","award":["1788\/31\/2019"],"award-info":[{"award-number":["1788\/31\/2019"]}]},{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"publisher","award":["1788\/31\/2019"],"award-info":[{"award-number":["1788\/31\/2019"]}],"id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Novel means to minimize treatment delays in patients with ST elevation myocardial infarction (STEMI) are needed. Using an accelerometer and gyroscope on the chest yield mechanocardiographic (MCG) data. We investigated whether STEMI causes changes in MCG signals which could help to detect STEMI. The study group consisted of 41 STEMI patients and 49 control patients referred for elective coronary angiography and having normal left ventricular function and no valvular heart disease or arrhythmia. MCG signals were recorded on the upper sternum in supine position upon arrival to the catheterization laboratory. In this study, we used a dedicated wearable sensor equipped with 3-axis accelerometer, 3-axis gyroscope and 1-lead ECG in order to facilitate the detection of STEMI in a clinically meaningful way. A supervised machine learning approach was used. Stability of beat morphology, signal strength, maximum amplitude and its timing were calculated in six axes from each window with varying band-pass filters in 2\u201390 Hz range. In total, 613 features were investigated. Using logistic regression classifier and leave-one-person-out cross validation we obtained a sensitivity of 73.9%, specificity of 85.7% and AUC of 0.857 (SD = 0.005) using 150 best features. As a result, mechanical signals recorded on the upper chest wall with the accelerometers and gyroscopes differ significantly between STEMI patients and stable patients with normal left ventricular function. Future research will show whether MCG can be used for the early screening of STEMI.<\/jats:p>","DOI":"10.3390\/s22124384","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T02:01:44Z","timestamp":1655085704000},"page":"4384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mechanocardiography in the Detection of Acute ST Elevation Myocardial Infarction: The MECHANO-STEMI Study"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-8999","authenticated-orcid":false,"given":"Tero","family":"Koivisto","sequence":"first","affiliation":[{"name":"Department of Computing, University of Turku, Vesilinnantie 5, 20500 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Lahdenoja","sequence":"additional","affiliation":[{"name":"Department of Computing, University of Turku, Vesilinnantie 5, 20500 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Hurnanen","sequence":"additional","affiliation":[{"name":"Department of Computing, University of Turku, Vesilinnantie 5, 20500 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuija","family":"Vasankari","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-6814","authenticated-orcid":false,"given":"Samuli","family":"Jaakkola","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0908-3741","authenticated-orcid":false,"given":"Tuomas","family":"Kiviniemi","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-568X","authenticated-orcid":false,"given":"K. 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Juhani","family":"Airaksinen","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/01.CIR.0000083720.35869.CA","article-title":"Decline in out-of-hospital coronary heart disease deaths has contributed the main part to the overall decline in coronary heart disease mortality rates among persons 35 to 64 years of age in Finland: The FINAMI Study","volume":"108","author":"Salomaa","year":"2003","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e007081","DOI":"10.1161\/CIRCINTERVENTIONS.118.007081","article-title":"Incidence, mortality, and outcome-predictors of sudden cardiac arrest complicating myocardial infarction prior to hospital admission","volume":"12","author":"Karam","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1038\/s41598-017-07248-y","article-title":"Gyrocardiography: A new non-invasive monitoring method for the assessment of cardiac mechanics and the estimation of hemodynamic variables","volume":"7","author":"Tadi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5405\/jmbe.847","article-title":"Mechanisms underlying isovolumic contraction and ejection peaks in seismocardiogram morphology","volume":"32","author":"Gurev","year":"2012","journal-title":"J. Med. Biol. Eng."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sieci\u0144ski, S., Kostka, P.S., and Tkacz, E.J. (2020). Gyrocardiography: A review of the definition, history, waveform description, and applications. 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Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"603319","DOI":"10.3389\/fcvm.2021.603319","article-title":"Quantification of Cardiac Kinetic Energy and Its Changes During Transmural Myocardial Infarction Assessed by Multi-Dimensional Seismocardiography","volume":"8","author":"Morra","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_9","first-page":"586","article-title":"Simplified detection of myocardial ischemia by seismocardiography. Differentiation between causes of altered myocardial function","volume":"39","author":"Becker","year":"2014","journal-title":"Herz"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e004313","DOI":"10.1161\/CIRCHEARTFAILURE.117.004313","article-title":"Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients","volume":"11","author":"Inan","year":"2018","journal-title":"Circ. Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1038\/s41598-018-27683-9","article-title":"Multiclass classifier based cardiovascular condition detection using smartphone mechanocardiography","volume":"8","author":"Iftikhar","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1161\/01.CIR.96.6.1798","article-title":"Acute myocardial infarction detected in the 12-lead ECG by artificial neural networks","volume":"96","author":"Rittner","year":"1997","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.artmed.2004.01.003","article-title":"Detecting acute myocardial infarction in the 12-lead ECG using Hermite expansions and neural networks","volume":"32","author":"Haraldsson","year":"2004","journal-title":"Artif. Intell. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.artmed.2006.07.006","article-title":"Comparison between neural networks and multiple logistic regression to predict acute coronary syndrome in the emergency room","volume":"38","author":"Green","year":"2006","journal-title":"Artif. Intell. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1475-097X.2006.00669.x","article-title":"Decision support for the initial triage of patients with acute coronary syndromes","volume":"26","author":"Olsson","year":"2006","journal-title":"Clin. Phys. Func. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1109\/JSEN.2019.2896308","article-title":"A novel approach for detection of myocardial infarction from ECG signals of multiple electrodes","volume":"19","author":"Tripathy","year":"2019","journal-title":"IEEE Sens. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1016\/S2589-7500(19)30026-3","article-title":"Feasibility and performance of a device for automatic self-detection of symptomatic acute coronary artery occlusion in outpatients with coronary artery disease: A multicentre observational study","volume":"1","author":"Heuverswyn","year":"2019","journal-title":"Lancet Digit. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1001\/jamacardio.2020.3994","article-title":"Multichannel Electrocardiograms Obtained by a Smartwatch for the Diagnosis of ST-Segment Changes","volume":"5","author":"Spaccarotella","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.jacc.2019.01.014","article-title":"Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction","volume":"73","author":"Gibson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","first-page":"I2","article-title":"Sudden cardiac death: Structure, function, and time-dependence of risk","volume":"85","author":"Myerburg","year":"1992","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/01.CIR.51.4.606","article-title":"Precursors of sudden coronary death. Factors related to the incidence of sudden death","volume":"51","author":"Kannel","year":"1975","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/07853899908995886","article-title":"Autonomic mechanisms and sudden death during abrupt coronary occlusion","volume":"31","author":"Airaksinen","year":"1999","journal-title":"Ann. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/01.CIR.60.2.397","article-title":"Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model","volume":"60","author":"Kaplinsky","year":"1979","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000087480.94275.97","article-title":"From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I","volume":"108","author":"Naghavi","year":"2003","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.amjcard.2008.07.056","article-title":"Trends in prehospital delay in patients with acute myocardial infarction (from the Worcester Heart Attack Study)","volume":"102","author":"Saczynski","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1109\/JBHI.2014.2361732","article-title":"Ballistocardiography and Seismocardiography: A Review of Recent Advances","volume":"19","author":"Inan","year":"2015","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1109\/JBHI.2019.2895775","article-title":"Performance Analysis of Gyroscope and Accelerometer Sensors for Seismocardiography-Based Wearable Pre-Ejection Period Estimation","volume":"23","author":"Shandhi","year":"2019","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1109\/JSEN.2018.2882874","article-title":"Comprehensive Analysis of Cardiogenic Vibrations for Automated Detection of Atrial Fibrillation Using Smartphone Mechanocardiograms","volume":"19","author":"Tadi","year":"2019","journal-title":"IEEE Sens. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/bja\/aen331","article-title":"Detection of myocardial ischaemia by epicardial accelerometers in the pig","volume":"102","author":"Halvorsen","year":"2009","journal-title":"Br. J. Anaesth."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1540-8159.2004.00496.x","article-title":"Detection of acute myocardial ischemia during percutaneous transluminal coronary angioplasty by endocardial acceleration","volume":"27","author":"Theres","year":"2004","journal-title":"PACE-Pacing Clin. Electrophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jelectrocard.2005.12.004","article-title":"Phonocardiographic timing of third and fourth heart sounds during acute myocardial infarction","volume":"39","author":"Harris","year":"2006","journal-title":"J. Electrocardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/pace.12059","article-title":"Feasibility of heart sounds measurements from an accelerometer within an icd pulse generator","volume":"36","author":"Siejko","year":"2013","journal-title":"PACE-Pacing Clin. Electrophysiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1001\/jama.293.18.2238","article-title":"Association between phonocardiographic third and fourth heart sounds and objective measures of left ventricular function","volume":"293","author":"Marcus","year":"2005","journal-title":"J. Am. Med. Assoc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1152\/ajpregu.00142.2020","article-title":"Influence of sympathetic activation on myocardial contractility measured with ballistocardiography and seismocardiography during sustained end-expiratory apnea","volume":"319","author":"Morra","year":"2020","journal-title":"Am. J. 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