{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:12:10Z","timestamp":1792789930429,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania","award":["PD 100\/2020"],"award-info":[{"award-number":["PD 100\/2020"]}]},{"name":"Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania","award":["PN-III-P1-1.1-PD-2019-0721"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2019-0721"]}]},{"name":"Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania","award":["PNCDI III"],"award-info":[{"award-number":["PNCDI III"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Diabetic autonomic neuropathy is probably the most undiagnosed but serious complication of diabetes. The main objectives were to assess the prevalence of peripheral and autonomic neuropathy in a population of diabetic patients, analyze it in a real-life outpatient unit scenario and determine the feasibility of performing SUDOSCAN tests together with widely used tests for neuropathy. A total of 33 patients were included in the study. Different scoring systems (the Toronto Clinical Neuropathy Score\u2014TCNS; the Neuropathy Disability Score\u2014NDS; and the Neuropathy Symptom Score\u2014NSS) were applied to record diabetic neuropathy (DN), while the SUDOSCAN medical device was used to assess sudomotor function, detect diabetic autonomic neuropathy and screen for cardiac autonomic neuropathy (CAN). Fifteen (45.5%) patients had sudomotor dysfunction. The SUDOSCAN CAN risk score was positively correlated with the hands\u2019 electrochemical sweat conductance (ESC), diastolic blood pressure (DBP), the level of the glycated hemoglobin, as well as with the TCNS, NDS and NSS. Performing SUDOSCAN tests together with other tests for DN proved to be a feasible approach that could be used in daily clinical practice in order to screen for DN, as well as for the early screening of CAN, before more complex and time-consuming tests.<\/jats:p>","DOI":"10.3390\/s22197571","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T05:12:21Z","timestamp":1665378741000},"page":"7571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["SUDOSCAN, an Innovative, Simple and Non-Invasive Medical Device for Assessing Sudomotor Function"],"prefix":"10.3390","volume":"22","author":[{"given":"Dana Elena","family":"Gavan","sequence":"first","affiliation":[{"name":"Clinic of Podiatry, 10 Iuliu Moldovan Street, 400348 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-4808","authenticated-orcid":false,"given":"Alexandru","family":"Gavan","sequence":"additional","affiliation":[{"name":"Department of Medical Devices, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 4 Louis Pasteur Street, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmina Ioana","family":"Bondor","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Florea","sequence":"additional","affiliation":[{"name":"Clinic of Podiatry, 10 Iuliu Moldovan Street, 400348 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Lee","family":"Bowling","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Manchester, Oxford Road, Manchester M13 9PL, UK"},{"name":"Department of Vascular Surgery and Reconstructive Microsurgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-6916","authenticated-orcid":false,"given":"Georgeta Victoria","family":"Inceu","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Nutrition and Metabolical Diseases, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 2\u20134 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-4861","authenticated-orcid":false,"given":"Liora","family":"Colobatiu","sequence":"additional","affiliation":[{"name":"Department of Medical Devices, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 4 Louis Pasteur Street, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.diabet.2010.05.004","article-title":"A new simple method for assessing sudomotor function: Relevance in type 2 diabetes","volume":"36","author":"Mayaudon","year":"2010","journal-title":"Diabetes Metab."},{"key":"ref_2","first-page":"CD010975","article-title":"Simple tests to screen for diabetic peripheral neuropathy","volume":"2018","author":"Yang","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_3","unstructured":"Boyko, E.J., Magliano, D.J., Karuranga, S., Piemonte, L., Riley, P., Saeedi, P., and Sun, H. (2021). IDF Diabetes Atlas, International Diabetes Federation. [10th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.autneu.2017.03.001","article-title":"Sudomotor dysfunction as a measure of small fiber neuropathy in type 1 diabetes","volume":"205","author":"Ang","year":"2017","journal-title":"Auton. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijdm.2009.08.001","article-title":"Chronic complications of diabetes mellitus in newly diagnosed patients","volume":"2","author":"Heydari","year":"2010","journal-title":"Int. J. Diabetes Mellit."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/B978-0-444-52902-2.00033-3","article-title":"Diabetic neuropathy","volume":"115","author":"Said","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12265-012-9367-6","article-title":"What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes","volume":"5","year":"2012","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fendo.2014.00205","article-title":"Autonomic neuropathy in diabetes mellitus","volume":"5","author":"Verrotti","year":"2014","journal-title":"Front. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.diabet.2012.09.004","article-title":"Screening of cardiovascular autonomic neuropathy in patients with diabetes using non-invasive quick and simple assessment of sudomotor function","volume":"39","author":"Yajnik","year":"2013","journal-title":"Diabetes Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/dc09-1294","article-title":"Cardiac autonomic neuropathy in diabetes: A clinical perspective","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diacare.26.5.1553","article-title":"Diabetic autonomic neuropathy","volume":"26","author":"Vinik","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: Update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jdiacomp.2014.02.013","article-title":"The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathy","volume":"28","author":"Smith","year":"2014","journal-title":"J. Diabetes Complicat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1177\/1932296816645362","article-title":"Long-term performance of point-of-care hemoglobin A1c assays","volume":"10","author":"Paknikar","year":"2016","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_15","unstructured":"(2022, August 10). Quantitative Measurement of the Glycated Hemoglobin Using the DCA Device. Available online: https:\/\/www.healthcare.siemens.com\/point-of-care\/diabetes\/dca-vantage-analyzer\/technical-specifications."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.2337\/dc08-9021","article-title":"Comprehensive foot examination and risk assessment: A report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists","volume":"31","author":"Boulton","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S1388-2457(03)00025-7","article-title":"Diabetic neuropathy: A review emphasizing diagnostic methods","volume":"114","author":"Perkins","year":"2003","journal-title":"Clin. Neurophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jdiacomp.2005.11.002","article-title":"Bedside neuropathy disability score compared to quantitative sensory testing for measurement of diabetic neuropathy in children, adolescents, and young adults with type 1 diabetes","volume":"21","author":"Weintrob","year":"2007","journal-title":"J. Diabetes Complicat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1089\/dia.2013.0129","article-title":"Sudoscan, a noninvasive tool for detecting diabetic small fiber neuropathy and autonomic dysfunction","volume":"15","author":"Casellini","year":"2013","journal-title":"Diabetes Technol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.diabres.2013.07.003","article-title":"Sudomotor function assessment as a screening tool for microvascular complications in type 2 diabetes","volume":"101","author":"Eranki","year":"2013","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.diabet.2011.05.003","article-title":"Non-invasive and quantitative assessment of sudomotor function for peripheral diabetic neuropathy evaluation","volume":"37","author":"Gin","year":"2011","journal-title":"Diabetes Metab."},{"key":"ref_22","first-page":"103714","article-title":"Quick and simple evaluation of sudomotor function for screening of diabetic neuropathy","volume":"2012","author":"Yajnik","year":"2012","journal-title":"Int. Sch. Res. Not."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fendo.2015.00094","article-title":"The new age of sudomotor function testing: A sensitive and specific biomarker for diagnosis, estimation of severity, monitoring progression, and regression in response to intervention","volume":"6","author":"Vinik","year":"2015","journal-title":"Front. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jcf.2010.09.002","article-title":"Abnormal electrochemical skin conductance in cystic fibrosis","volume":"10","author":"Hubert","year":"2011","journal-title":"J. Cyst. Fibros."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8435252","DOI":"10.1155\/2017\/8435252","article-title":"Association of SUDOSCAN values with vibration perception threshold in Chinese patients with type 2 diabetes mellitus","volume":"2017","author":"Zhu","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1464-5491.2008.02458.x","article-title":"Relationship between autonomic neuropathy and hypertension\u2014Are we underestimating the problem?","volume":"25","author":"Istenes","year":"2008","journal-title":"Diabet. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/jhh.2015.126","article-title":"Cardiac autonomic neuropathy risk estimated by sudomotor function and arterial stiffness in Chinese subjects","volume":"30","author":"Zeng","year":"2016","journal-title":"J. Hum. Hypertens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pcd.2013.08.001","article-title":"Assessment of small fiber neuropathy to predict future risk of type 2 diabetes","volume":"7","author":"Parfentyeva","year":"2013","journal-title":"Prim. Care Diabetes"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1464-5491.2010.03027.x","article-title":"Association between cardiac autonomic neuropathy and hypertension and its potential influence on diabetic complications","volume":"27","author":"Ayad","year":"2010","journal-title":"Diabet. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.2337\/diacare.26.7.2213","article-title":"Risk factors of autonomic and sensory nerve dysfunction in patients with newly diagnosed type 1 diabetes","volume":"26","author":"Keresztes","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1161\/01.HYP.14.2.177","article-title":"Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings","volume":"14","author":"Anderson","year":"1989","journal-title":"Hypertension"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/01.HYP.32.2.293","article-title":"Reduced heart rate variability and new-onset hypertension: Insights into pathogenesis of hypertension: The Framingham Heart Study","volume":"32","author":"Singh","year":"1998","journal-title":"Hypertension"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e012307","DOI":"10.1136\/bmjopen-2016-012307","article-title":"Nocturnal antihypertensive treatment in patients with type 1 diabetes with autonomic neuropathy and non-dipping: A randomised, placebo-controlled, double-blind cross-over trial","volume":"6","author":"Jensen","year":"2016","journal-title":"BMJ Open"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1056-8727(00)00054-4","article-title":"Cardiovascular autonomic neuropathy (expiration and inspiration ratio) in type 1 diabetes: Incidence and predictors","volume":"14","author":"Stella","year":"2000","journal-title":"J. Diabetes Complicat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00125-004-1617-y","article-title":"Risk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus","volume":"48","author":"Witte","year":"2005","journal-title":"Diabetologia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/diacare.24.2.250","article-title":"Simple screening tests for peripheral neuropathy in the diabetes clinic","volume":"24","author":"Perkins","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.2337\/diacare.25.11.2048","article-title":"Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy","volume":"25","author":"Bril","year":"2002","journal-title":"Diabetes Care"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/19\/7571\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:14Z","timestamp":1760143634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/22\/19\/7571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":37,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["s22197571"],"URL":"https:\/\/doi.org\/10.3390\/s22197571","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]}}}