{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:41:59Z","timestamp":1792096919280,"version":"4.4.0"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and technology plan project in the field of social development of Zhuhai City","award":["2220004000067"],"award-info":[{"award-number":["2220004000067"]}]},{"name":"Science and technology plan project in the field of social development of Zhuhai City","award":["2019B010150002"],"award-info":[{"award-number":["2019B010150002"]}]},{"name":"Science and technology plan project in the field of social development of Zhuhai City","award":["pdjh2021b0911"],"award-info":[{"award-number":["pdjh2021b0911"]}]},{"name":"Science and technology plan project in the field of social development of Zhuhai City","award":["pdjh2022b0911"],"award-info":[{"award-number":["pdjh2022b0911"]}]},{"name":"Guangdong Province Key Areas R&amp;D Program","award":["2220004000067"],"award-info":[{"award-number":["2220004000067"]}]},{"name":"Guangdong Province Key Areas R&amp;D Program","award":["2019B010150002"],"award-info":[{"award-number":["2019B010150002"]}]},{"name":"Guangdong Province Key Areas R&amp;D Program","award":["pdjh2021b0911"],"award-info":[{"award-number":["pdjh2021b0911"]}]},{"name":"Guangdong Province Key Areas R&amp;D Program","award":["pdjh2022b0911"],"award-info":[{"award-number":["pdjh2022b0911"]}]},{"name":"Special Fund for Science and Technology Innovation Strategy of Guangdong Province","award":["2220004000067"],"award-info":[{"award-number":["2220004000067"]}]},{"name":"Special Fund for Science and Technology Innovation Strategy of Guangdong Province","award":["2019B010150002"],"award-info":[{"award-number":["2019B010150002"]}]},{"name":"Special Fund for Science and Technology Innovation Strategy of Guangdong Province","award":["pdjh2021b0911"],"award-info":[{"award-number":["pdjh2021b0911"]}]},{"name":"Special Fund for Science and Technology Innovation Strategy of Guangdong Province","award":["pdjh2022b0911"],"award-info":[{"award-number":["pdjh2022b0911"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Retinopathy of prematurity is an ophthalmic disease with a very high blindness rate. With its increasing incidence year by year, its timely diagnosis and treatment are of great significance. Due to the lack of timely and effective fundus screening for premature infants in remote areas, leading to an aggravation of the disease and even blindness, in this paper, a deep learning-based collaborative edge-cloud telemedicine system is proposed to mitigate this issue. In the proposed system, deep learning algorithms are mainly used for classification of processed images. Our algorithm is based on ResNet101 and uses undersampling and resampling to improve the data imbalance problem in the field of medical image processing. Artificial intelligence algorithms are combined with a collaborative edge\u2013cloud architecture to implement a comprehensive telemedicine system to realize timely screening and diagnosis of retinopathy of prematurity in remote areas with shortages or a complete lack of expert medical staff. Finally, the algorithm is successfully embedded in a mobile terminal device and deployed through the support of a core hospital of Guangdong Province. The results show that we achieved 75% ACC and 60% AUC. This research is of great significance for the development of telemedicine systems and aims to mitigate the lack of medical resources and their uneven distribution in rural areas.<\/jats:p>","DOI":"10.3390\/s23010276","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T05:31:54Z","timestamp":1672205514000},"page":"276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Deep-Learning-Based Collaborative Edge\u2013Cloud Telemedicine System for Retinopathy of Prematurity"],"prefix":"10.3390","volume":"23","author":[{"given":"Zeliang","family":"Luo","sequence":"first","affiliation":[{"name":"College of Electro-Mechanical Engineering, Zhuhai City Polytechnic, Zhuhai 519090, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-7016","authenticated-orcid":false,"given":"Xiaoxuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Hou","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9188-4179","authenticated-orcid":false,"given":"Jiafu","family":"Wan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing, School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Huang, Y.P., Vadloori, S., Chu, H.C., Kang, E.Y.C., Wu, W.C., Kusaka, S., and Fukushima, Y. 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