{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:21:57Z","timestamp":1774113717169,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut d\u2019Alembert, ENS Paris Saclay, BIMODIAG grant","award":["4, 2020\u20132022"],"award-info":[{"award-number":["4, 2020\u20132022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The accurate, rapid, and specific detection of DNA strands in solution is becoming increasingly important, especially in biomedical applications such as the trace detection of COVID-19 or cancer diagnosis. In this work we present the design, elaboration and characterization of an optofluidic sensor based on a polymer-based microresonator which shows a quick response time, a low detection limit and good sensitivity. The device is composed of a micro-racetrack waveguide vertically coupled to a bus waveguide and embedded within a microfluidic circuit. The spectral response of the microresonator, in air or immersed in deionised water, shows quality factors up to 72,900 and contrasts up to 0.9. The concentration of DNA strands in water is related to the spectral shift of the microresonator transmission function, as measured at the inflection points of resonance peaks in order to optimize the signal-over-noise ratio. After functionalization by a DNA probe strand on the surface of the microresonator, a specific and real time measurement of the complementary DNA strands in the solution is realized. Additionally, we have inferred the dissociation constant value of the binding equilibrium of the two complementary DNA strands and evidenced a sensitivity of 16.0 pm\/\u00b5M and a detection limit of 121 nM.<\/jats:p>","DOI":"10.3390\/s23177373","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:47:08Z","timestamp":1692874028000},"page":"7373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Optofluidic Sensor Based on Polymer Optical Microresonators for the Specific, Sensitive and Fast Detection of Chemical and Biochemical Species"],"prefix":"10.3390","volume":"23","author":[{"given":"Nolwenn-Amandine","family":"Keriel","sequence":"first","affiliation":[{"name":"Laboratoire Lumi\u00e8re, Mati\u00e8re et Interfaces (LuMIn), Ecole Normale Superieure Paris Saclay, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 9024, CentraleSupelec, Institut d\u2019Alembert, Universit\u00e9 Paris Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Delezoide","sequence":"additional","affiliation":[{"name":"Laboratoire Lumi\u00e8re, Mati\u00e8re et Interfaces (LuMIn), Ecole Normale Superieure Paris Saclay, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 9024, CentraleSupelec, Institut d\u2019Alembert, Universit\u00e9 Paris Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chauvin","sequence":"additional","affiliation":[{"name":"Laboratoire Lumi\u00e8re, Mati\u00e8re et Interfaces (LuMIn), Ecole Normale Superieure Paris Saclay, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 9024, CentraleSupelec, Institut d\u2019Alembert, Universit\u00e9 Paris Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5858-5385","authenticated-orcid":false,"given":"Hafsa","family":"Korri-Youssoufi","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay (ICMMO), Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 8182, Universit\u00e9 Paris Saclay, 17 Avenue des Sciences, 91400 Orsay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-683X","authenticated-orcid":false,"given":"Ngoc Diep","family":"Lai","sequence":"additional","affiliation":[{"name":"Laboratoire Lumi\u00e8re, Mati\u00e8re et Interfaces (LuMIn), Ecole Normale Superieure Paris Saclay, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 9024, CentraleSupelec, Institut d\u2019Alembert, Universit\u00e9 Paris Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Ledoux-Rak","sequence":"additional","affiliation":[{"name":"Laboratoire Lumi\u00e8re, Mati\u00e8re et Interfaces (LuMIn), Ecole Normale Superieure Paris Saclay, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 9024, CentraleSupelec, Institut d\u2019Alembert, Universit\u00e9 Paris Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Laboratoire Lumi\u00e8re, Mati\u00e8re et Interfaces (LuMIn), Ecole Normale Superieure Paris Saclay, Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 9024, CentraleSupelec, Institut d\u2019Alembert, Universit\u00e9 Paris Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pelt-Verkuil, E., Belkum, A., and Hays, J.P. 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