{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:54:36Z","timestamp":1788404076532,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan\u2019s ministry of science and technology","award":["MOST 111-2221-E-027-098-MY2"],"award-info":[{"award-number":["MOST 111-2221-E-027-098-MY2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Electrochemical sensors, due to their excellent and unique features, are of high interest nowadays for the detection and monitoring of several biological compounds. In such a case, serotonin (SRN), an important neurotransmitter, was herein studied for its detection in biological fluids since its presence is more crucial to be monitored and detected in clinical and medical applications. Several study strategies have been used to determine the chemical and physical properties. The crystalline size of the constructed copper sulfide (Cu2S) material was measured to be 25.92 nm. The Cu2S was fabricated over the working surface and further analyzed for several sensor parameters to be optimized. The charge transfer resistance of the copper sulfide-modified glassy carbon electrode (Cu2S\/GCE) was determined to be about 277.0 \u03a9. With the linear range from about 0.029 \u03bcM to 607.6 \u03bcM for SRN, the limit of detection (LOD) was calculated as 3.2 nM, with a good sensitivity of 13.23 \u03bcA \u03bcM\u22121 cm2. The sensor experienced excellent repeatability, reproducibility, and long-term stability. The fabricated electrode was selective with the presence of different interfering compounds. The real sample analysis, as determined with the regular addition method with human serum and urine samples, revealed a good recovery percentage. Thus, the employed fabricated electrode material will be highly effective in sensing other analytes of choice.<\/jats:p>","DOI":"10.3390\/s23218849","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:53:32Z","timestamp":1698756812000},"page":"8849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Facile Synthesis of Needle-like Copper Sulfide Structures as an Effective Electrochemical Sensor Material for Neurotransmitter Detection in Biological Samples"],"prefix":"10.3390","volume":"23","author":[{"given":"Aravindan","family":"Santhan","sequence":"first","affiliation":[{"name":"Department of Molecular Science and Engineering, National Taipei University of Technology, Taipei 10608, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Yuan","family":"Hwa","sequence":"additional","affiliation":[{"name":"Department of Molecular Science and Engineering, National Taipei University of Technology, Taipei 10608, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.snb.2014.01.100","article-title":"Electrochemical Serotonin Sensing Interface Based on Double-Layered Membrane of Reduced Graphene Oxide\/Polyaniline Nanocomposites and Molecularly Imprinted Polymers Embedded with Gold Nanoparticles","volume":"196","author":"Xue","year":"2014","journal-title":"Sens. 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