{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:52:10Z","timestamp":1790758330728,"version":"4.1.0"},"reference-count":57,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott Medical GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Heart failure (HF) is a complex clinical syndrome associated with significant morbidity, mortality, and healthcare costs. It is characterized by various structural and\/or functional abnormalities of the heart, resulting in elevated intracardiac pressure and\/or inadequate cardiac output at rest and\/or during exercise. These dysfunctions can originate from a variety of conditions, including coronary artery disease, hypertension, cardiomyopathies, heart valve disorders, arrhythmias, and other lifestyle or systemic factors. Identifying the underlying cause is crucial for detecting reversible or treatable forms of HF. Recent epidemiological studies indicate that there has not been an increase in the incidence of the disease. Instead, patients seem to experience a chronic trajectory marked by frequent hospitalizations and stagnant mortality rates. Managing these patients requires a multidisciplinary approach that focuses on preventing disease progression, controlling symptoms, and preventing acute decompensations. In the outpatient setting, patient self-care plays a vital role in achieving these goals. This involves implementing necessary lifestyle changes and promptly recognizing symptoms\/signs such as dyspnea, lower limb edema, or unexpected weight gain over a few days, to alert the healthcare team for evaluation of medication adjustments. Traditional methods of HF monitoring, such as symptom assessment and periodic clinic visits, may not capture subtle changes in hemodynamics. Sensor-based technologies offer a promising solution for remote monitoring of HF patients, enabling early detection of fluid overload and optimization of medical therapy. In this review, we provide an overview of the CardioMEMS device, a novel sensor-based system for pulmonary artery pressure monitoring in HF patients. We discuss the technical aspects, clinical evidence, and future directions of CardioMEMS in HF management.<\/jats:p>","DOI":"10.3390\/s24092922","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:52:02Z","timestamp":1714715522000},"page":"2922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["MEMS Technology in Cardiology: Advancements and Applications in Heart Failure Management Focusing on the CardioMEMS Device"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3189-7116","authenticated-orcid":false,"given":"Francesco","family":"Ciotola","sequence":"first","affiliation":[{"name":"Medizinische Klinik I, Klinikum F\u00fcrth, Academic Teaching Hospital of the Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Jakob-Henle Str. 1, 90766 F\u00fcrth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Pyxaras","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Klinikum F\u00fcrth, Academic Teaching Hospital of the Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Jakob-Henle Str. 1, 90766 F\u00fcrth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Rittger","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Klinikum F\u00fcrth, Academic Teaching Hospital of the Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Jakob-Henle Str. 1, 90766 F\u00fcrth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-9241","authenticated-orcid":false,"given":"Veronica","family":"Buia","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Klinikum F\u00fcrth, Academic Teaching Hospital of the Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Jakob-Henle Str. 1, 90766 F\u00fcrth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00392-012-0531-4","article-title":"Generic and disease- specific health-related quality of life in patients with chronic systolic heart failure: Impact of depression","volume":"102","author":"Schowalter","year":"2013","journal-title":"Clin. Res. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","article-title":"The global health and economic burden of hospitalizations for heart failure: Lessons learned from hospitalized heart failure registries","volume":"63","author":"Ambrosy","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/ejhf.1594","article-title":"Survival of patients with chronic heart failure in the community: A systematic review and meta- analysis","volume":"21","author":"Jones","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/eurheartj\/eht066","article-title":"Incidence and epidemiology of new onset heart failure with preserved vs reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND","volume":"34","author":"Brouwers","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(17)32520-5","article-title":"Temporal trends and patterns in heart failure incidence: A population-based study of 4 million indi- viduals","volume":"391","author":"Conrad","year":"2018","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/CIRCRESAHA.121.318172","article-title":"Roger, Epidemiology of Heart Failure, a contemporary perspective","volume":"128","author":"Veronique","year":"2021","journal-title":"Circ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCHEARTFAILURE.113.001281","article-title":"Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction","volume":"7","author":"Bello","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11G","DOI":"10.1016\/j.amjcard.2005.07.016","article-title":"Pathophysiologic targets in the early phase of acute heart failure syndromes","volume":"96","author":"Gheorghiade","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S1388-9842(01)00190-8","article-title":"Compliance and effectiveness of 1 year\u2019s home telemonitoring. The report of a pilot study of patients with chronic heart failure","volume":"3","author":"Wells","year":"2001","journal-title":"Eur. J. Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/17434440.2023.2196400","article-title":"The CardioMEMS Heart Failure System for chronic heart failure\u2014A European perspective","volume":"20","author":"Radhoe","year":"2023","journal-title":"Expert. Rev. Med. Devices"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.31083\/j.rcm2202046","article-title":"Chronic disease management in heart failure: Focus on telemedicine and remote monitoring","volume":"22","author":"Alvarez","year":"2021","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/europace\/euv293","article-title":"The lung impedance monitoring in treatment of chronic heart failure (the LIMIT-CHF study)","volume":"18","author":"Domenichini","year":"2016","journal-title":"Europace"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jacc.2017.05.052","article-title":"Implantable Hemodynamic monitoring for heart failure patients","volume":"70","author":"Abraham","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S0140-6736(16)00704-2","article-title":"A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): A multicentre open-label, single-arm, phase 1 trial","volume":"387","author":"Hasenfuss","year":"2016","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.4244\/EIJY14M05_07","article-title":"Left atrial decompression through unidirectional left-to-right interatrial shunt for the treatment of left heart failure: First-in-man experience with the V-Wave device","volume":"10","author":"Bergeron","year":"2015","journal-title":"EuroIntervention"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jacc.2007.10.061","article-title":"Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: The COMPASS-HF study","volume":"51","author":"Bourge","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Radhoe, S.P., Veenis, J.F., and Brugts, J.J. (2021). Invasive devices and sensors for remote care of heart failure patients. Sensors, 21.","DOI":"10.3390\/s21062014"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/17434440.2020.1779588","article-title":"CardioMEMS(TM) system in the daily management of heart failure: Review of current data and technique of implantation","volume":"17","author":"Mangi","year":"2020","journal-title":"Expert. Rev. Med. Devices"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0140-6736(11)60101-3","article-title":"Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: A randomised controlled trial","volume":"377","author":"Abraham","year":"2011","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(15)00723-0","article-title":"Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: Complete follow-up results from the CHAMPION randomised trial","volume":"387","author":"Abraham","year":"2016","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0140-6736(21)01754-2","article-title":"Haemodynamic-guided management of heart failure (GUIDE-HF): A randomised controlled trial","volume":"398","author":"Lindenfeld","year":"2021","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e006863","DOI":"10.1161\/CIRCHEARTFAILURE.119.006863","article-title":"Lower rates of heart failure and all-cause hospitalizations during pulmonary artery pressure-guided therapy for ambulatory heart failure: One-year out- comes from the CardioMEMS post-approval study","volume":"13","author":"Shavelle","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/S0140-6736(23)00923-6","article-title":"Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): A randomised clinical trial","volume":"401","author":"Brugts","year":"2023","journal-title":"Lancet"},{"key":"ref_25","unstructured":"Gad-el-Hak, M. (2014). MEMS: Design and Fabrication, CRC Press."},{"key":"ref_26","unstructured":"Judy, D.J. (2016). MEMS and Microsystems: Design, Manufacture, and Nanoscale Engineering, Wiley."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1117\/12.141220","article-title":"Silicon integrated microsensors","volume":"1793","author":"Najafi","year":"1993","journal-title":"Integr. Opt. Microstruct."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chircov, C., and Grumezescu, A.M. (2022). Microelectromechanical Systems (MEMS) for Biomedical Applications. Micromachines, 13.","DOI":"10.3390\/mi13020164"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Carminati, M. (2020). Challenges for Microelectronics in Non-Invasive Medical Diagnostics. Sensors, 20.","DOI":"10.3390\/s20133636"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hfc.2023.05.002","article-title":"Remote Monitoring Devices and Heart Failure","volume":"20","author":"Gupta","year":"2024","journal-title":"Heart Fail. Clin."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1540-8159.2005.00176.x","article-title":"Chronicle Investigators. Implant experience with an implantable hemodynamic monitor for the management of symptomatic heart failure","volume":"28","author":"Steinhaus","year":"2005","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Clephas, P.R.D., Aydin, D., Radhoe, S.P., and Brugts, J.J. (2023). Recent Advances in Remote Pulmonary Artery Pressure Monitoring for Patients with Chronic Heart Failure: Current Evidence and Future Perspectives. Sensors, 23.","DOI":"10.3390\/s23031364"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cardfail.2022.09.006","article-title":"Rationale and Design of the Proactive-HF Trial for Managing Patients with NYHA Class III Heart Failure by Using the Combined Cordella Pulmonary Artery Sensor and the Cordella Heart Failure System","volume":"29","author":"Guichard","year":"2023","journal-title":"J. Card. Fail."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.hlc.2005.09.003","article-title":"The Heartpod implantable heart failure therapy system","volume":"14","author":"Walton","year":"2005","journal-title":"Heart Lung Circ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1161\/CIRCULATIONAHA.107.702191","article-title":"Direct left atrial pressure monitoring in ambulatory heart failure patients: Initial experience with a new permanent implantable device","volume":"116","author":"Ritzema","year":"2007","journal-title":"Circulation"},{"key":"ref_36","first-page":"19","article-title":"Transcatheter Implantable Devices to Monitoring of Elevated Left Atrial Pressures in Patients with Chronic Heart Failure","volume":"17","author":"Piscione","year":"2018","journal-title":"Transl. Med. UniSa"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"P940","DOI":"10.1016\/j.cardfail.2016.09.012","article-title":"Hemodynamic Monitoring in Advanced Heart Failure: Results from the LAPTOP-HF Trial","volume":"11","author":"Abraham","year":"2016","journal-title":"J. Card. Fail."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/ejhf.2869","article-title":"Safety, usability, and performance of a wireless left atrial pressure monitoring system in patients with heart failure: The VECTOR-HF trial","volume":"25","author":"Meerkin","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"ref_39","unstructured":"(2014). CardioMEMS HF System User\u2019s Manual, CardioMEMS Inc.. 387 Technology Circle NW."},{"key":"ref_40","first-page":"273","article-title":"The CardioMEMS Heart Failure Sensor: A Procedural Guide for Implanting Physicians","volume":"28","author":"Shavelle","year":"2016","journal-title":"J. Invasive Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1001\/jamacardio.2017.3791","article-title":"Postmarketing Adverse Events Related to the CardioMEMS HF System","volume":"2","author":"Vaduganathan","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e007892","DOI":"10.1161\/CIRCHEARTFAILURE.120.007892","article-title":"Remote Hemodynamic Monitoring Equally Reduces Heart Failure Hospitalizations in Women and Men in Clinical Practice: A Sex-Specific Analysis of the CardioMEMS Post-Approval Study","volume":"14","author":"DeFilippis","year":"2021","journal-title":"Circ. Heart Fail."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"801","DOI":"10.5603\/CJ.2021.0140","article-title":"An Apple Watch a day keeps the doctor away?","volume":"28","author":"Basza","year":"2021","journal-title":"Cardiol. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/17461391.2021.2023656","article-title":"Wrist-worn devices for the measurement of heart rate and energy expenditure: A validation study for the Apple Watch 6, Polar Vantage V and Fitbit Sense","volume":"23","author":"Comtois","year":"2023","journal-title":"Eur. J. Sport. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e50701","DOI":"10.2196\/50701","article-title":"Diagnostic Accuracy of Single-Lead Electrocardiograms Using the Kardia Mobile App and the Apple Watch 4: Validation Study","volume":"7","author":"Klier","year":"2023","journal-title":"JMIR Cardio"},{"key":"ref_46","first-page":"CD011845","article-title":"mHealth education interventions in heart failure","volume":"7","author":"Allida","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.amjcard.2006.08.066","article-title":"Intrathoracic impedance monitoring to predict decompensated heart failure","volume":"99","author":"Ypenburg","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"386","DOI":"10.21037\/cdt.2019.01.02","article-title":"Device monitoring in heart failure management: Outcomes based on a systematic review and meta-analysis","volume":"9","author":"Halawa","year":"2019","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1109\/JSEN.2008.917481","article-title":"State-of-the-Art in Force and Tactile Sensing for Minimally Invasive Surgery","volume":"8","author":"Puangmali","year":"2008","journal-title":"IEEE Sens. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2302812","DOI":"10.1002\/adfm.202302812","article-title":"A Highly Integrated 3D MEMS Force Sensing Module With Variable Sensitivity for Robotic-Assisted Minimally Invasive Surgery","volume":"33","author":"Hou","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1109\/TBCAS.2009.2032267","article-title":"Studies of MEMS Acoustic Sensors as Implantable Microphones for Totally Implantable Hearing-Aid Systems","volume":"3","author":"Ko","year":"2009","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_53","first-page":"S1257","article-title":"MEMS-based system and image processing strategy for epiretinal prosthesis","volume":"26","author":"Xia","year":"2015","journal-title":"Biomed. Mater. Eng."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e006768","DOI":"10.1161\/CIRCINTERVENTIONS.118.006768","article-title":"LV-MEMS: A New Challenger Against the CHAMPION?","volume":"11","author":"Ishikawa","year":"2018","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"568886","DOI":"10.3389\/fphys.2020.568886","article-title":"Hearables: New Perspectives and Pitfalls of In-Ear Devices for Physiological Monitoring","volume":"11","author":"Micarelli","year":"2020","journal-title":"Scoping Rev. Front. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1357633X221134952","article-title":"Ensuring privacy in telemedicine: Ethical and clinical challenges","volume":"29","author":"Mishkin","year":"2023","journal-title":"J. Telemed. Telecare"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jsmc.2020.06.002","article-title":"Telemedicine Coding and Reimbursement\u2014Current and Future Trends","volume":"15","year":"2020","journal-title":"Sleep Med. Clin."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/9\/2922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:39:08Z","timestamp":1760107148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/9\/2922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":57,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["s24092922"],"URL":"https:\/\/doi.org\/10.3390\/s24092922","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]}}}