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The analyte is able to flow into the hollow core through the side-opening to form new fiber core, with the Gaussian-like mode propagating in it. We investigate the sensing performance of the proposed sensor in a higher RI range of 1.48 to 1.54 at two feasible schemes: one is to only fill the fiber core with analyte (Scheme A), and the other is to directly immerse the sensor in the analyte (Scheme B). The results demonstrate that our sensor exhibits higher wavelength sensitivity at Scheme A with a maximum wavelength sensitivity of 12,320 nm\/RIU, while a greater amplitude sensitivity was found at Scheme B with a maximum amplitude sensitivity of 1146 RIU\u22121. Our proposed sensor features the advantages of simple fabrication, flexible operation, easy analyte filling and replacing, enhanced real-time detection capabilities, high RI detection, and very high wavelength sensitivity and amplitude sensitivity, which makes it more competitive in SPR sensing applications.<\/jats:p>","DOI":"10.3390\/s24134335","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T03:52:58Z","timestamp":1720065178000},"page":"4335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Side-Opened Hollow Fiber-Based SPR Sensor for High Refractive Index Detection"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8244-9886","authenticated-orcid":false,"given":"Ge","family":"Meng","sequence":"first","affiliation":[{"name":"School of Electronics and Information Engineering, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3305-2707","authenticated-orcid":false,"given":"Nannan","family":"Luan","sequence":"additional","affiliation":[{"name":"School of Electronics and Information Engineering, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"He","sequence":"additional","affiliation":[{"name":"School of Electronics and Information Engineering, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Resources Monitoring and Supervision in Southern Hilly Region, Ministry of Natural Resources, Changsha 410000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Electronics and Information Engineering, Hebei University of Technology, Tianjin 300401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1021\/cr068107d","article-title":"Surface plasmon resonance sensors for detection of chemical and biological species","volume":"108","author":"Homola","year":"2008","journal-title":"Chem. 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