{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:20:12Z","timestamp":1760145612643,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Austrian COMET-K2 programme of the Linz Center of Mechatronics (LCM)"},{"name":"Austrian federal government and the federal state of Upper Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Total knee arthroplasty (TKA) is a well-established and successful treatment option for patients with end-stage osteoarthritis of the knee, providing high patient satisfaction. Robotic systems have been widely adopted to perform TKA in orthopaedic centres. The exact spatial positions of the femur and tibia are usually determined through pinned trackers, providing the surgeon with an exact illustration of the axis of the lower limb. The drilling of holes required for mounting the trackers creates weak spots, causing adverse events such as bone fracture. In the presented computational feasibility study, time differential electrical impedance tomography is used to locate the femur positions, thereby the difference in conductivity distribution between two distinct states s0 and s1 of the measured object is reconstructed. The overall approach was tested by simulating five different configurations of thigh shape and considered tissue conductivity distributions. For the cylinder models used for verification and reference, the reconstructed position deviated by about \u22481 mm from the actual bone centre. In case of models mimicking a realistic cross section of the femur position deviated between 7.9 mm 24.8 mm. For all models, the bone axis was off by about \u03c6=1.50\u00b0 from its actual position.<\/jats:p>","DOI":"10.3390\/s24165269","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T10:28:41Z","timestamp":1723631321000},"page":"5269","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DEIT-Based Bone Position and Orientation Estimation for Robotic Support in Total Knee Arthroplasty\u2014A Computational Feasibility Study"],"prefix":"10.3390","volume":"24","author":[{"given":"Jakob","family":"Schrott","sequence":"first","affiliation":[{"name":"Institute of Measurement Technology, Johannes Kepler University, 4020 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Affortunati","sequence":"additional","affiliation":[{"name":"Institute of Measurement Technology, Johannes Kepler University, 4020 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-7199","authenticated-orcid":false,"given":"Christian","family":"Stadler","sequence":"additional","affiliation":[{"name":"Department for Orthopedics and Traumatology, Kepler University Hospital, 4020 Linz, Austria"},{"name":"Medical Faculty, Johannes Kepler University, 4020 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-4216","authenticated-orcid":false,"given":"Christoph","family":"Hinterm\u00fcller","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Mechatronics, Johannes Kepler University, 4020 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2106\/JBJS.M.00372","article-title":"Intermediate and Long-Term Quality of Life After Total Knee Replacement: A Systematic Review and Meta-Analysis","volume":"97","author":"Shan","year":"2015","journal-title":"JBJS"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.arth.2022.06.014","article-title":"Computer-Navigated and Robotic-Assisted Total Knee Arthroplasty: Increasing in Popularity Without Increasing Complications","volume":"37","author":"Wang","year":"2022","journal-title":"J. Arthroplast."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.arth.2018.01.060","article-title":"Robotic Arm-Assisted Total Knee Arthroplasty","volume":"33","author":"Khlopas","year":"2018","journal-title":"J. Arthroplast."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101196","DOI":"10.1016\/j.artd.2023.101196","article-title":"Robotic-Assisted Total Knee Arthroplasty Can Increase Frequency of Achieving Target Limb Alignment in Primary Total Knee Arthroplasty for Preoperative Valgus Deformity","volume":"23","author":"Wininger","year":"2023","journal-title":"Arthroplast. Today"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.arth.2013.12.010","article-title":"Robot-Assisted Total Knee Arthroplasty Accurately Restores the Joint Line and Mechanical Axis. A Prospective Randomised Study","volume":"29","author":"Liow","year":"2014","journal-title":"J. Arthroplast."},{"key":"ref_6","first-page":"337","article-title":"Improved Component Placement Accuracy with Robotic-Arm Assisted Total Knee Arthroplasty","volume":"35","author":"Mahoney","year":"2020","journal-title":"J. Knee Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1302\/2058-5241.4.190022","article-title":"Robotic technology in total knee arthroplasty: A systematic review","volume":"4","author":"Kayani","year":"2019","journal-title":"EFORT Open Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00264-018-4116-3","article-title":"Total knee arthroplasty in the varus knee: Tips and tricks","volume":"43","author":"Rossi","year":"2019","journal-title":"Int. Orthop."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00264-013-2227-4","article-title":"Total knee arthroplasty in the valgus knee","volume":"38","author":"Rossi","year":"2014","journal-title":"Int. Orthop."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.arth.2023.01.060","article-title":"Current Concepts in Alignment in Total Knee Arthroplasty","volume":"38","author":"Karasavvidis","year":"2023","journal-title":"J. Arthroplast."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.otsr.2017.07.010","article-title":"Alignment options for total knee arthroplasty: A systematic review","volume":"103","author":"Iranpour","year":"2017","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1001\/archinternmed.2009.440","article-title":"Projected Cancer Risks From Computed Tomographic Scans Performed in the United States in 2007","volume":"169","author":"Mahesh","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00402-021-04208-0","article-title":"The MAKO robotic-arm knee arthroplasty system","volume":"141","author":"Roche","year":"2021","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_14","first-page":"1295","article-title":"Initial Experience with the NAVIO Robotic-Assisted Total Knee Replacement\u2013Coronal Alignment Accuracy and the Learning Curve","volume":"35","author":"Collins","year":"2021","journal-title":"J. Knee Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.arth.2022.03.060","article-title":"Adverse Events Associated With Robotic-Assisted Joint Arthroplasty: An Analysis of the US Food and Drug Administration MAUDE Database","volume":"37","author":"Pagani","year":"2022","journal-title":"J. Arthroplast."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s00256-022-04034-4","article-title":"Fracture through tracking pin sites following a robotic-assisted total knee arthroplasty","volume":"51","author":"Feroe","year":"2022","journal-title":"Skelet. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.2106\/JBJS.RVW.20.00091","article-title":"Periprosthetic Fractures Through Tracking Pin Sites Following Computer Navigated and Robotic Total and Unicompartmental Knee Arthroplasty: A Systematic Review","volume":"9","author":"Smith","year":"2021","journal-title":"JBJS Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e15195","DOI":"10.1016\/j.heliyon.2023.e15195","article-title":"Robust electrical impedance tomography for biological application: A mini review","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"key":"ref_19","first-page":"20210713","article-title":"Robust imaging using electrical impedance tomography: Review of current tools","volume":"478","author":"Brazey","year":"2022","journal-title":"Proc. R. Soc. A Math. Phys. Eng. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Adler, A., and Boyle, A. (2019). Electrical Impedance Tomography. Wiley Encyclopedia of Electrical and Electronics Engineering, John Wiley & Sons, Ltd.","DOI":"10.1002\/047134608X.W1431.pub2"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e0843","DOI":"10.1097\/CCE.0000000000000843","article-title":"Electrical Impedance Tomography As a Bedside Diagnostic Tool for Pulmonary Embolism","volume":"5","author":"Prins","year":"2023","journal-title":"Crit. Care Explor."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40560-023-00691-2","article-title":"A novel method for diaphragm-based electrode belt position of electrical impedance tomography by ultrasound","volume":"11","author":"Yue","year":"2023","journal-title":"J. Intensive Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/anesthres1010002","article-title":"Electrical Impedance Tomography (EIT) to Optimize Ventilatory Management in Critically Ill Patients: A Report of Two Cases","volume":"1","author":"Cappellini","year":"2024","journal-title":"Anesth. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"074003","DOI":"10.1088\/1361-6579\/ac0e85","article-title":"Clinical value of electrical impedance tomography (EIT) in the management of patients with acute respiratory failure: A single centre experience","volume":"42","author":"Bronco","year":"2021","journal-title":"Physiol. Meas."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chung, C.R., Ko, R.E., Jang, G.Y., Lee, K., Suh, G.Y., Kim, Y., and Woo, E.J. (2024). Comparison of noninvasive cardiac output and stroke volume measurements using electrical impedance tomography with invasive methods in a swine model. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-53488-0"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2478\/joeb-2020-0007","article-title":"Electrode Positioning to Investigate the Changes of the Thoracic Bioimpedance Caused by Aortic Dissection - A Simulation Study","volume":"11","author":"Badeli","year":"2020","journal-title":"J. Electr. Bioimpedance"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Ye, J., Jiao, Y., Zhang, W., Zhang, T., Tian, X., Shi, X., Fu, F., Wang, L., and Xu, C. (2022). A pilot study of contrast-enhanced electrical impedance tomography for real-time imaging of cerebral perfusion. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.1027948"},{"key":"ref_28","first-page":"10","article-title":"Advances in electrical impedance tomography-based brain imaging","volume":"9","author":"Ke","year":"2022","journal-title":"Mil. Med. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tan, H., and Rossa, C. (2021). Electrical Impedance Tomography for Robot-Aided Internal Radiation Therapy. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.698038"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Murillo-Ortiz, B., Hern\u00e1ndez-Ram\u00edrez, A., Rivera-Villanueva, T., Su\u00e1rez-Garc\u00eda, D., Murgu\u00eda-P\u00e9rez, M., Mart\u00ednez-Garza, S., Rodr\u00edguez-Penin, A., Romero-Coripuna, R., and L\u00f3pez-Partida, X.M. (2020). Monofrequency electrical impedance mammography (EIM) diagnostic system in breast cancer screening. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07283-5"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chen, S., Zhang, K., Li, M., Zhang, Y., Wang, Y., Yang, F., Xu, S., and Abubakar, A. (2022, January 16\u201318). Application of Electrical Impedance Tomography for Monitoring Tissue Water Content of the Thigh. Proceedings of the 2022 IEEE MTT-S International Microwave Biomedical Conference (IMBioC), Suzhou, China.","DOI":"10.1109\/IMBioC52515.2022.9790141"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5617\/jeb.2657","article-title":"Simulation of impedance measurements at human forearm within 1 kHz to 2 MHz","volume":"7","author":"Anand","year":"2016","journal-title":"J. Electr. Bioimpedance"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Vilchez-Monge, M., Canales-Vasquez, D., and Rimolo-Donadio, R. (2017, January 10\u201312). Image Reconstruction of the Human Foearm by Electrical Impedance Tomography. Proceedings of the 2017 International Conference and Workshop on Bioinspired Intelligence (IWOBI), Funchal, Portugal.","DOI":"10.1109\/IWOBI.2017.7985535"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wei, W., and Kolb, J.F. (October, January 29). Impedance Properties of Trabecular Bone Based on Different Analytical Methods. Proceedings of the 2021 International Workshop on Impedance Spectroscopy (IWIS), Chemnitz, Germany.","DOI":"10.1109\/IWIS54661.2021.9711811"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Darma, P.N., Ibrahim, K.A., and Takei, M. (2021, January 25\u201327). Super High-speed Cross-sectional Imaging of Fat, Muscle, and Bone by Machine Learning and EIT. Proceedings of the 2021 International Conference on Instrumentation, Control, and Automation (ICA), Bandung, Indonesia.","DOI":"10.1109\/ICA52848.2021.9625686"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gajre, S.S., Anand, S., Singh, U., and Saxena, R.K. (September, January 30). Novel method of using dynamic electrical impedance signals for noninvasive diagnosis of knee osteoarthritis. Proceedings of the 2006 International Conference of the IEEE Engineering in Medicine and Biology Society, New York, NY, USA.","DOI":"10.1109\/IEMBS.2006.260671"},{"key":"ref_37","unstructured":"Zhu, J., Lei, Y., Shah, A., Schein, G., Ghaednia, H., Schwab, J., Harteveld, C., and Mueller, S. (November, January 29). MuscleRehab: Improving Unsupervised Physical Rehabilitation by Monitoring and Visualizing Muscle Engagement. Proceedings of the 35th Annual ACM Symposium on User Interface Software and Technology, UIST \u201922, Bend, OR, USA."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhu, J., Snowden, J.C., Verdejo, J., Chen, E., Zhang, P., Ghaednia, H., Schwab, J.H., and Mueller, S. (2021, January 10\u201314). EIT-kit: An Electrical Impedance Tomography Toolkit for Health and Motion Sensing. Proceedings of the 34th Annual ACM Symposium on User Interface Software and Technology, UIST \u201921, Virtual Event, USA.","DOI":"10.1145\/3472749.3474758"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ren, Z., and Yang, W. (2015, January 16\u201318). 3D positioning for revision total hip replacement surgery by dual-modality tomography. Proceedings of the 2015 IEEE International Conference on Imaging Systems and Techniques (IST), Macau, China.","DOI":"10.1109\/IST.2015.7294565"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1109\/TIM.2016.2608098","article-title":"Development of a Navigation Tool for Revision Total Hip Surgery Based on Electrical Impedance Tomography","volume":"65","author":"Ren","year":"2016","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Gupta, S., Lee, H.J., Loh, K.J., Todd, M.D., Reed, J., and Barnett, A.D. (2018). Noncontact Strain Monitoring of Osseointegrated Prostheses. Sensors, 18.","DOI":"10.3390\/s18093015"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"124001","DOI":"10.1088\/1361-6579\/aca26b","article-title":"Fast absolute 3D CGO-based electrical impedance tomography on experimental tank data","volume":"43","author":"Hamilton","year":"2022","journal-title":"Physiol. Meas."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TIM.2021.3123218","article-title":"Estimating Homogeneous Reference Frame for Absolute Electrical Impedance Tomography Through Measurements and Scale Feature","volume":"70","author":"Wang","year":"2021","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_44","first-page":"1","article-title":"Estimation of Reference Voltages for Time-Difference Electrical Impedance Tomography","volume":"71","author":"Yu","year":"2022","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"141999","DOI":"10.1109\/ACCESS.2021.3119565","article-title":"Target Adaptive Differential Iterative Reconstruction (TADI): A Robust Algorithm for Real-Time Electrical Impedance Tomography","volume":"9","author":"Zhang","year":"2021","journal-title":"IEEE Access"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1088\/0967-3334\/27\/5\/S03","article-title":"Uses and abuses of EIDORS: An extensible software base for EIT","volume":"27","author":"Adler","year":"2006","journal-title":"Physiol. Meas."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1088\/0967-3334\/29\/6\/S08","article-title":"Direct EIT Jacobian calculations for conductivity change and electrode movement","volume":"29","author":"Adler","year":"2008","journal-title":"Physiol. Meas."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1109\/TBME.2017.2728323","article-title":"Electrical Impedance Tomography: Tissue Properties to Image Measures","volume":"64","author":"Adler","year":"2017","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_49","unstructured":"Shewchuk, J.R. (2024, April 30). An Introduction to the Conjugate Gradient Method without the Agonizing Pain. Available online: https:\/\/www.cs.cmu.edu\/~quake-papers\/painless-conjugate-gradient.pdf."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: Fundamental Algorithms for Scientific Computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Nocedal, J., and Wright, S.J. (2006). Quasi-Newton Methods. Numerical Optimization, Springer. [2nd ed.]. Chapter 6.","DOI":"10.1007\/978-0-387-40065-5_6"},{"key":"ref_52","unstructured":"Asogwa, C.O., Seyedi, M., and Lai, D.T.H. (October, January 30). A preliminary investigation of human body composition using galvanically coupled signals. Proceedings of the 9th International Conference on Body Area Networks, BodyNets \u201914, Brussels, Belgium."},{"key":"ref_53","unstructured":"(2015). Medical Electrical Equipment Part 1: General Requirements for Basic Safety and Essential Performance (Standard No. IEC 60601-1:2015)."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1109\/TIM.2022.3166796","article-title":"Multifrequency Electrical Impedance Tomography With Ratiometric Preprocessing for Imaging Human Body Compartments","volume":"71","author":"Ogawa","year":"2022","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Creegan, A., Nielsen, P.M.F., and Tawhai, M.H. (2024). A novel two-dimensional phantom for electrical impedance tomography using 3D printing. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-52696-y"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Imran, A. (2012). Sagittal plane knee laxity after ligament retaining unconstrained arthroplasty: A mathematical analysis. J. Mech. Med. Biol., 12.","DOI":"10.1142\/S0219519412400027"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/16\/5269\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:36:44Z","timestamp":1760110604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/16\/5269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":56,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["s24165269"],"URL":"https:\/\/doi.org\/10.3390\/s24165269","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2024,8,14]]}}}