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Since its inception in the 1980s, 3D printing has experienced a huge rise in popularity. This study uses cost-effective, flexible, and sustainable components that enable specific features of certain gas chromatography. This study aims to optimize the process of gas detection using a 3D printed separation column and the MiCS-6814 sensor. The principle of the entire device is based on the idea of utilizing a simple capillary chromatographic column manufactured by 3D printing for the separation of samples into components prior to their measurement using inexpensive chemiresistive sensors. An optimization of a system with a 3D printed PLA block containing a capillary, a mixing chamber, and a measuring chamber with a MiCS-6814 sensor was performed. The optimization distributed the sensor output signal in the time domain so that it was possible to distinguish the peak for the two most common alcohols, ethanol and methanol. The paper further describes some optimization types and their possibilities.<\/jats:p>","DOI":"10.3390\/s24206594","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T07:58:32Z","timestamp":1729065512000},"page":"6594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing Low-Cost Gas Analysis with a 3D Printed Column and MiCS-6814 Sensor for Volatile Compound Detection"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7828-9187","authenticated-orcid":false,"given":"Nela","family":"Skowronkova","sequence":"first","affiliation":[{"name":"Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-863X","authenticated-orcid":false,"given":"Martin","family":"Adamek","sequence":"additional","affiliation":[{"name":"Department of Automation and Control Engineering, Faculty of Applied Informatics, Tomas Bata University in Zlin, Nad Stranemi 4511, 760 05 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-7608","authenticated-orcid":false,"given":"Magdalena","family":"Zvonkova","sequence":"additional","affiliation":[{"name":"Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-4485","authenticated-orcid":false,"given":"Jiri","family":"Matyas","sequence":"additional","affiliation":[{"name":"Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-9670","authenticated-orcid":false,"given":"Anna","family":"Adamkova","sequence":"additional","affiliation":[{"name":"Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stepan","family":"Dlabaja","sequence":"additional","affiliation":[{"name":"Department of Automation and Control Engineering, Faculty of Applied Informatics, Tomas Bata University in Zlin, Nad Stranemi 4511, 760 05 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-7698","authenticated-orcid":false,"given":"Martin","family":"Buran","sequence":"additional","affiliation":[{"name":"Department of Microelectronics, Faculty of Electrical Engineering and Communication, Brno University of Technology, Technicka 3058\/10, 616 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-2435","authenticated-orcid":false,"given":"Veronika","family":"Sevcikova","sequence":"additional","affiliation":[{"name":"Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-8560","authenticated-orcid":false,"given":"Jiri","family":"Mlcek","sequence":"additional","affiliation":[{"name":"Department of Food Analysis and Chemistry, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova 5669, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-2726","authenticated-orcid":false,"given":"Zdenek","family":"Volek","sequence":"additional","affiliation":[{"name":"Department of Nutritional Physiology and Animal Product Quality, Institute of Animal Science, Pratelstvi 815, 104 00 Prague, Czech Republic"},{"name":"Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, 165 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Cernekova","sequence":"additional","affiliation":[{"name":"Department of Fat, Surfactant and Cosmetics Technology, Faculty of Technology, Tomas Bata University in Zlin, Vavreckova, 275, 760 01 Zlin, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sahana, V.W., and Thampi, G.T. 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