{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:29:55Z","timestamp":1793514595651,"version":"4.5.0"},"reference-count":106,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Recovery and Resilience Plan (NRRP)","award":["1409"],"award-info":[{"award-number":["1409"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["PRIN-PNRR-P2022F79PA_001"],"award-info":[{"award-number":["PRIN-PNRR-P2022F79PA_001"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["28017"],"award-info":[{"award-number":["28017"]}]},{"name":"European Union\u2014NextGenerationEU","award":["1409"],"award-info":[{"award-number":["1409"]}]},{"name":"European Union\u2014NextGenerationEU","award":["PRIN-PNRR-P2022F79PA_001"],"award-info":[{"award-number":["PRIN-PNRR-P2022F79PA_001"]}]},{"name":"European Union\u2014NextGenerationEU","award":["28017"],"award-info":[{"award-number":["28017"]}]},{"name":"AIRC (Italian Association for Cancer Research)","award":["1409"],"award-info":[{"award-number":["1409"]}]},{"name":"AIRC (Italian Association for Cancer Research)","award":["PRIN-PNRR-P2022F79PA_001"],"award-info":[{"award-number":["PRIN-PNRR-P2022F79PA_001"]}]},{"name":"AIRC (Italian Association for Cancer Research)","award":["28017"],"award-info":[{"award-number":["28017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Bladder cancer is one of the most common cancers worldwide. Despite its high incidence, cystoscopy remains the currently used diagnostic gold standard, although it is invasive, expensive and has low sensitivity. As a result, the cancer diagnosis is mostly late, as it occurs following the presence of hematuria in urine, and population screening is not allowed. It would therefore be desirable to be able to act promptly in the early stage of the disease with the aid of biosensing. The use of devices\/tools based on genetic assessments would be of great help in this field. However, the genetic differences between populations do not allow accurate analysis in the context of population screening. Current research is directed towards the discovery of universal biomarkers present in urine with the aim of providing an approach based on a non-invasive, easy-to-perform, rapid, and accurate test that can be widely used in clinical practice for the early diagnosis and follow-up of bladder cancer. An efficient biosensing device may have a disruptive impact in terms of patient health and disease management, contributing to a decrease in mortality rate, as well as easing the social and economic burden on the national healthcare system. Considering the advantage of accessing population screening for early diagnosis of cancer, the main challenges and future perspectives are critically discussed to address the research towards the selection of suitable biomarkers for the development of a very sensitive biosensor for bladder cancer.<\/jats:p>","DOI":"10.3390\/s24247873","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:17:20Z","timestamp":1733829440000},"page":"7873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["New Challenges in Bladder Cancer Diagnosis: How Biosensing Tools Can Lead to Population Screening Opportunities"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-102X","authenticated-orcid":false,"given":"Fabiana","family":"Tortora","sequence":"first","affiliation":[{"name":"Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Guastaferro","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Barbato","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3653-9847","authenticated-orcid":false,"given":"Ferdinando","family":"Febbraio","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-9299","authenticated-orcid":false,"given":"Amelia","family":"Cimmino","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Biophysics \u201cA. Buzzati Traverso\u201d, National Research Council (CNR), 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"04109","DOI":"10.7189\/jogh.13.04109","article-title":"The Global Landscape of Bladder Cancer Incidence and Mortality in 2020 and Projections to 2040","volume":"13","author":"Zhang","year":"2023","journal-title":"J. Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wong, M.C.S., Fung, F.D.H., Leung, C., Cheung, W.W.L., Goggins, W.B., and Ng, C.F. (2018). The Global Epidemiology of Bladder Cancer: A Joinpoint Regression Analysis of Its Incidence and Mortality Trends and Projection. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-19199-z"},{"key":"ref_4","unstructured":"Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., Pi\u00f1eros, M., Znaor, A., Soerjomataram, I., and Bray, F. (2024). Global Cancer Observatory: Cancer Today (Version 1.1), International Agency for Research on Cancer. Available online: https:\/\/gco.iarc.who.int\/today."},{"key":"ref_5","first-page":"485","article-title":"Risk Factors for Bladder Cancer: Results of a Survey of Hospital Patients","volume":"9","author":"Shadab","year":"2023","journal-title":"J. Cancer Allied Spec."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/cncr.29047","article-title":"Bladder Cancer Collaborative Stage Variables and Their Data Quality, Usage, and Clinical Implications: A Review of SEER Data, 2004\u20132010","volume":"120","author":"Sun","year":"2014","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dobruch, J., and Oszczud\u0142owski, M. (2021). Bladder Cancer: Current Challenges and Future Directions. Medicina, 57.","DOI":"10.3390\/medicina57080749"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.eururo.2011.03.027","article-title":"Select Screening in a Specific High-Risk Population of Patients Suggests a Stage Migration toward Detection of Non-Muscle-Invasive Bladder Cancer","volume":"59","author":"Zlotta","year":"2011","journal-title":"Eur. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.juro.2014.06.079","article-title":"A Novel Urine Cytology Stain for the Detection and Monitoring of Bladder Cancer","volume":"192","author":"Davis","year":"2014","journal-title":"J. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yoo, J.W., Koo, K.C., Chung, B.H., Baek, S.Y., Lee, S.J., Park, K.H., and Lee, K.S. (2022). Deep Learning Diagnostics for Bladder Tumor Identification and Grade Prediction Using RGB Method. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-22797-7"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/CU9.0000000000000012","article-title":"Comparison of the Clinical Usefulness of Different Urinary Tests for the Initial Detection of Bladder Cancer: A Systematic Review","volume":"15","author":"Sciarra","year":"2021","journal-title":"Curr. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/dc.24530","article-title":"Predictive Value of MCM5 (ADXBLADDER) Analysis in Urine of Men Evaluated for the Initial Diagnosis of Bladder Cancer: A Comparative Prospective Study","volume":"48","author":"Anastasi","year":"2020","journal-title":"Diagn. Cytopathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jasc.2020.09.013","article-title":"Urinary Tract Cytology: A Cytologic-Histopathologic Correlation with the Paris System, an Institutional Study","volume":"10","author":"Danakas","year":"2021","journal-title":"J. Am. Soc. Cytopathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.euo.2019.06.017","article-title":"Management of Patients with Normal Cystoscopy but Positive Cytology or Urine Markers","volume":"3","author":"Palou","year":"2020","journal-title":"Eur. Urol. Oncol."},{"key":"ref_15","first-page":"594","article-title":"The Pathologist\u2019s Role in the Detection of Rare Variants of Bladder Cancer and Analysis of the Impact on Incidence and Type Detection","volume":"70","author":"Mantica","year":"2018","journal-title":"Minerva Urol. Nefrol. Ital. J. Urol. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nrurol.2015.100","article-title":"Developing Proteomic Biomarkers for Bladder Cancer: Towards Clinical Application","volume":"12","author":"Frantzi","year":"2015","journal-title":"Nat. Rev. Urol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1464-410X.2010.10026.x","article-title":"Prospective Trial to Identify Optimal Bladder Cancer Surveillance Protocol: Reducing Costs While Maximizing Sensitivity","volume":"108","author":"Kamat","year":"2011","journal-title":"BJU Int."},{"key":"ref_18","first-page":"355","article-title":"Bladder Cancer Histological Variants: Which Parameters Could Predict the Concordance between Transurethral Resection of Bladder Tumor and Radical Cystectomy Specimens?","volume":"74","author":"Mantica","year":"2021","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41585-020-0304-1","article-title":"Genomic Heterogeneity in Bladder Cancer: Challenges and Possible Solutions to Improve Outcomes","volume":"17","author":"Meeks","year":"2020","journal-title":"Nat. Rev. Urol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.urolonc.2020.08.016","article-title":"Urinary Biomarkers in Bladder Cancer: A Review of the Current Landscape and Future Directions","volume":"39","author":"Ng","year":"2021","journal-title":"Urol. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3233\/BLC-160054","article-title":"A Systematic Review of the Diagnostic and Prognostic Value of Urinary Protein Biomarkers in Urothelial Bladder Cancer","volume":"2","author":"Goldsmith","year":"2016","journal-title":"Bladder Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Moon, C., Gordon, M., Moon, D., and Reynolds, T. (2021). Microsatellite Instability Analysis (MSA) for Bladder Cancer: Past History and Future Directions. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312864"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Oeyen, E., Hoekx, L., De Wachter, S., Baldewijns, M., Ameye, F., and Mertens, I. (2019). Bladder Cancer Diagnosis and Follow-Up: The Current Status and Possible Role of Extracellular Vesicles. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040821"},{"key":"ref_24","first-page":"471","article-title":"Bladder Epicheck\u00ae for Surveillance in High-Risk Non-Muscle-Invasive Bladder Cancer: Initial Experience and Follow-up Proposal","volume":"47","year":"2023","journal-title":"Actas Urol. Esp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"484.e17","DOI":"10.1016\/j.urolonc.2023.06.013","article-title":"BTA Stat\u00ae, NMP22\u00ae BladderChek\u00ae, UBC\u00ae Rapid Test, and CancerCheck\u00ae UBC\u00ae Rapid VISUAL as Urinary Marker for Bladder Cancer: Final Results of a German Multicenter Study","volume":"41","author":"Ecke","year":"2023","journal-title":"Urol. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0094-0143(05)70235-4","article-title":"The Application of Human Complement Factor H-Related Protein (BTA TRAK) in Monitoring Patients with Bladder Cancer","volume":"27","author":"Malkowicz","year":"2000","journal-title":"Urol. Clin. N. Am."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"296.e1","DOI":"10.1016\/j.urolonc.2022.12.012","article-title":"Performance of CellDetect for Detection of Bladder Cancer: Comparison with Urine Cytology and UroVysion","volume":"41","author":"Shefer","year":"2023","journal-title":"Urol. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"326.e1","DOI":"10.1016\/j.urolonc.2023.01.009","article-title":"Cxbladder Monitor Testing to Reduce Cystoscopy Frequency in Patients with Bladder Cancer","volume":"41","author":"Li","year":"2023","journal-title":"Urol. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/dc.23857","article-title":"Impact of Variant Microscopic Interpretation of the uCyt+ Immunocytological Urine Test for the Detection of Bladder Cancer","volume":"46","author":"Deininger","year":"2018","journal-title":"Diagn. Cytopathol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ibrahim, M., Rabinowitz, J., Hilbert, R., Ghose, A., Agarwal, S., Swamy, R., Bulut, I., Guttierrez, M., Buali, E., and Nassar, E. (2024). The Role of URO17\u00ae in Diagnosis and Follow up of Bladder Cancer Patients. BMC Urol., 24.","DOI":"10.1186\/s12894-024-01426-7"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kavcic, N., Peric, I., Zagorac, A., and Kokalj Vokac, N. (2022). Clinical Evaluation of Two Non-Invasive Genetic Tests for Detection and Monitoring of Urothelial Carcinoma: Validation of UroVysion and Xpert Bladder Cancer Detection Test. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.839598"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cell.2024.02.041","article-title":"Cancer Biomarkers\u2014Emerging Trends and Clinical Implications for Personalized Treatment","volume":"187","author":"Passaro","year":"2024","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1080\/14737159.2023.2277366","article-title":"Beyond Blood Biomarkers: The Role of SelectMDX in Clinically Significant Prostate Cancer Identification","volume":"23","author":"Ferro","year":"2023","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Hwang, C., Lee, W.-J., Kim, S.D., Park, S., and Kim, J.H. (2022). Recent Advances in Biosensor Technologies for Point-of-Care Urinalysis. Biosensors, 12.","DOI":"10.3390\/bios12111020"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"100516","DOI":"10.1016\/j.ceja.2023.100516","article-title":"Fundamentals of Bio-Electrochemical Sensing","volume":"16","author":"Shanbhag","year":"2023","journal-title":"Chem. Eng. J. Adv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-024-01823-2","article-title":"Tumor Biomarkers for Diagnosis, Prognosis and Targeted Therapy","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sequeira-Antunes, B., and Ferreira, H.A. (2023). Nucleic Acid Aptamer-Based Biosensors: A Review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11123201"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s44222-023-00067-z","article-title":"Biomolecular Sensors for Advanced Physiological Monitoring","volume":"1","author":"Flynn","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"101801","DOI":"10.1016\/j.xcrp.2024.101801","article-title":"Bioreceptors as the Key Components for Electrochemical Biosensing in Medicine","volume":"5","author":"Wang","year":"2024","journal-title":"Cell Rep. Phys. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2217\/fon.15.318","article-title":"Biomarkers in Localized Prostate Cancer","volume":"12","author":"Ferro","year":"2016","journal-title":"Future Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ferro, M., De Cobelli, O., Lucarelli, G., Porreca, A., Busetto, G.M., Cantiello, F., Damiano, R., Autorino, R., Musi, G., and Vartolomei, M.D. (2020). Beyond PSA: The Role of Prostate Health Index (Phi). Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041184"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"134224","DOI":"10.1016\/j.snb.2023.134224","article-title":"A Multi-Unit Integrated Electrochemical Biosensor Array for Synergistic Signal Enhancing Carbohydrate Antigen 125 Detection","volume":"393","author":"Liu","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s00216-021-03835-1","article-title":"A 3D Printable Adapter for Solid-State Fluorescence Measurements: The Case of an Immobilized Enzymatic Bioreceptor for Organophosphate Pesticides Detection","volume":"414","author":"Rodrigues","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kulkarni, M.B., Ayachit, N.H., and Aminabhavi, T.M. (2022). Biosensors and Microfluidic Biosensors: From Fabrication to Application. Biosensors, 12.","DOI":"10.3390\/bios12070543"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Trinh, K.T.L. (2022). Microfluidic Biosensors for Point-of-Care Nucleic Acid Amplification Tests. Biosensors, 13.","DOI":"10.3390\/bios13010005"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/2211068215581349","article-title":"Development and Applications of Portable Biosensors","volume":"20","author":"Srinivasan","year":"2015","journal-title":"J. Lab. Autom."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.pdpdt.2019.08.001","article-title":"Biosensor Device for the Photo-Specific Detection of Immuno-Captured Bladder Cancer Cells Using Hexaminolevulinate: An Ex-Vivo Study","volume":"28","author":"Chan","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"MacGregor, M., Safizadeh Shirazi, H., Chan, K.M., Ostrikov, K., McNicholas, K., Jay, A., Chong, M., Staudacher, A.H., Michl, T.D., and Zhalgasbaikyzy, A. (2021). Cancer Cell Detection Device for the Diagnosis of Bladder Cancer from Urine. Biosens. Bioelectron., 171.","DOI":"10.1016\/j.bios.2020.112699"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bhattacharyya, N., Mukherjee, D., Singh, S., Ghosh, R., Karmakar, S., Mallick, A., Chattopadhyay, A., Mondal, P., Mondal, T., and Bhattacharyya, D. (2022). \u201cSeeing\u201d Invisible Volatile Organic Compound (VOC) Marker of Urinary Bladder Cancer: A Development from Bench to Bedside Prototype Spectroscopic Device. Biosens. Bioelectron., 218.","DOI":"10.1016\/j.bios.2022.114764"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11440","DOI":"10.1021\/acs.analchem.3c01786","article-title":"Ultrasensitive Electrochemiluminescence Immunosensor for Bladder Marker Human Complement Factor H-Related Protein Detection","volume":"95","author":"Zhang","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.bios.2018.07.003","article-title":"Electrochemical ELISA-Based Platform for Bladder Cancer Protein Biomarker Detection in Urine","volume":"117","author":"Arya","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1039\/D4CC00996G","article-title":"Potential-Resolved Electrochemiluminescence for Simultaneous Determination of Multiplex Bladder Cancer Markers","volume":"60","author":"Wang","year":"2024","journal-title":"Chem. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3233\/CBM-160572","article-title":"Podoplanin Serum and Urine Concentration in Transitional Bladder Cancer","volume":"16","author":"Sankiewicz","year":"2016","journal-title":"Cancer Biomark. Sect. Dis. Markers"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Guszcz, T., Sankiewicz, A., and Gorodkiewicz, E. (2023). Application of Surface Plasmon Resonance Imaging Biosensors for Determination of Fibronectin, Laminin-5 and Type IV Collagen in Serum of Transitional Bladder Cancer Patients. J. Pharm. Biomed. Anal., 222.","DOI":"10.1016\/j.jpba.2022.115103"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1021\/acs.analchem.2c03156","article-title":"Flexible Point-of-Care Electrodes for Ultrasensitive Detection of Bladder Tumor-Relevant miRNA in Urine","volume":"95","author":"Chen","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-0716-1803-5_6","article-title":"Ultrasensitive Label-Free Nucleic-Acid Biosensors Based on Bimodal Waveguide Interferometers","volume":"2393","author":"Huertas","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Cheng, L., Yang, F., Zhao, Y., Liu, Z., Yao, X., and Zhang, J. (2023). Tetrahedron Supported CRISPR\/Cas13a Cleavage for Electrochemical Detection of Circular RNA in Bladder Cancer. Biosens. Bioelectron., 222.","DOI":"10.1016\/j.bios.2022.114982"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/jjco\/hyi244","article-title":"Comparison of NMP22 BladderChek Test and Urine Cytology for the Detection of Recurrent Bladder Cancer","volume":"36","author":"Kumar","year":"2006","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"119718","DOI":"10.1016\/j.cca.2024.119718","article-title":"Nuclear Matrix Protein 22 in Bladder Cancer","volume":"560","author":"Cheng","year":"2024","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1001\/jama.293.7.810","article-title":"Detection of Bladder Cancer Using a Point-of-Care Proteomic Assay","volume":"293","author":"Grossman","year":"2005","journal-title":"JAMA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.295.3.299","article-title":"Surveillance for Recurrent Bladder Cancer Using a Point-of-Care Proteomic Assay","volume":"295","author":"Grossman","year":"2006","journal-title":"JAMA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"28865","DOI":"10.1039\/D0RA06191C","article-title":"A Highly Sensitive Fluorescent Immunosensor for Sensitive Detection of Nuclear Matrix Protein 22 as Biomarker for Early Stage Diagnosis of Bladder Cancer","volume":"10","author":"Othman","year":"2020","journal-title":"RSC Adv."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/0306312717741687","article-title":"Machine Learning, Social Learning and the Governance of Self-Driving Cars","volume":"48","author":"Stilgoe","year":"2018","journal-title":"Soc. Stud. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"103537","DOI":"10.1016\/j.nepr.2022.103537","article-title":"Open Artificial Intelligence Platforms in Nursing Education: Tools for Academic Progress or Abuse?","volume":"66","year":"2023","journal-title":"Nurse Educ. Pract."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"103601","DOI":"10.1016\/j.critrevonc.2022.103601","article-title":"Artificial Intelligence: A Promising Frontier in Bladder Cancer Diagnosis and Outcome Prediction","volume":"171","author":"Borhani","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"308","DOI":"10.12965\/jer.2142596.298","article-title":"Applications of Artificial Intelligence in Urological Setting: A Hopeful Path to Improved Care","volume":"17","author":"Eun","year":"2021","journal-title":"J. Exerc. Rehabil."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s13073-021-00968-x","article-title":"Deep Learning in Cancer Diagnosis, Prognosis and Treatment Selection","volume":"13","author":"Tran","year":"2021","journal-title":"Genome Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/cncy.22443","article-title":"A Deep Learning System to Diagnose the Malignant Potential of Urothelial Carcinoma Cells in Cytology Specimens","volume":"129","author":"Nojima","year":"2021","journal-title":"Cancer Cytopathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/cyto.a.24313","article-title":"Deep Learning Based Digital Cell Profiles for Risk Stratification of Urine Cytology Images","volume":"99","author":"Awan","year":"2021","journal-title":"Cytom. Part A J. Int. Soc. Anal. Cytol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/cncy.22099","article-title":"Automating the Paris System for Urine Cytopathology-A Hybrid Deep-Learning and Morphometric Approach","volume":"127","author":"Vaickus","year":"2019","journal-title":"Cancer Cytopathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/cncy.22176","article-title":"Performance of an Artificial Intelligence Algorithm for Reporting Urine Cytopathology","volume":"127","author":"Sanghvi","year":"2019","journal-title":"Cancer Cytopathol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ebiom.2017.12.026","article-title":"Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images","volume":"27","author":"Khosravi","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"12920","DOI":"10.1073\/pnas.1816459115","article-title":"Noninvasive Diagnostic Imaging Using Machine-Learning Analysis of Nanoresolution Images of Cell Surfaces: Detection of Bladder Cancer","volume":"115","author":"Sokolov","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5569458","DOI":"10.1155\/2021\/5569458","article-title":"A Calibrated Multiexit Neural Network for Detecting Urothelial Cancer Cells","volume":"2021","author":"Lilli","year":"2021","journal-title":"Comput. Math. Methods Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"38802","DOI":"10.18632\/oncotarget.16393","article-title":"Metabolite Marker Discovery for the Detection of Bladder Cancer by Comparative Metabolomics","volume":"8","author":"Shao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_76","first-page":"94","article-title":"Recognition of Early and Late Stages of Bladder Cancer Using Metabolites and Machine Learning","volume":"15","author":"Kouznetsova","year":"2019","journal-title":"Metabolomics Off. J. Metabolomic Soc."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s11548-017-1522-8","article-title":"Three-Dimensional Texture Features from Intensity and High-Order Derivative Maps for the Discrimination between Bladder Tumors and Wall Tissues via MRI","volume":"12","author":"Xu","year":"2017","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ebiom.2018.07.029","article-title":"Development and Validation of an MRI-Based Radiomics Signature for the Preoperative Prediction of Lymph Node Metastasis in Bladder Cancer","volume":"34","author":"Wu","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1002\/cncr.32490","article-title":"Development of a Noninvasive Tool to Preoperatively Evaluate the Muscular Invasiveness of Bladder Cancer Using a Radiomics Approach","volume":"125","author":"Zheng","year":"2019","journal-title":"Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.euf.2021.05.005","article-title":"Role of Radiomics in the Prediction of Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-Analysis","volume":"8","author":"Kozikowski","year":"2022","journal-title":"Eur. Urol. Focus"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/JU.0000000000001373","article-title":"Prospective Validation of Vesical Imaging-Reporting and Data System Using a Next-Generation Magnetic Resonance Imaging Scanner-Is Denoising Deep Learning Reconstruction Useful?","volume":"205","author":"Taguchi","year":"2021","journal-title":"J. Urol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Min, K., Ikram, W., Tatton, R.W., Riaz, I.B., Silva, A.C., Bryce, A.H., Moore, C., Ho, T.H., and Sonpavde, G. (2023). Performing Automatic Identification and Staging of Urothelial Carcinoma in Bladder Cancer Patients Using a Hybrid Deep-Machine Learning Approach. Cancers, 15.","DOI":"10.3390\/cancers15061673"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2471\/BLT.24.291326","article-title":"Global Health Inequities: More Challenges, Some Solutions","volume":"102","author":"Tangcharoensathien","year":"2024","journal-title":"Bull. World Health Organ."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.neubiorev.2021.05.019","article-title":"Explaining Socioeconomic Disparities in Health Behaviours: A Review of Biopsychological Pathways Involving Stress and Inflammation","volume":"127","author":"Kraft","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_85","first-page":"e33425","article-title":"The Role of Social Determinants of Health in Promoting Health Equality: A Narrative Review","volume":"15","author":"Chelak","year":"2023","journal-title":"Cureus"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Minhas, A.M.K., Jain, V., Li, M., Ariss, R.W., Fudim, M., Michos, E.D., Virani, S.S., Sperling, L., and Mehta, A. (2023). Family Income and Cardiovascular Disease Risk in American Adults. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-27474-x"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1001\/jamainternmed.2021.2441","article-title":"Socioeconomic Inequality in Respiratory Health in the US From 1959 to 2018","volume":"181","author":"Gaffney","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Su, D., Chen, Y., Tan, M., and Chen, X. (2022). Effect of Socioeconomic Status on the Physical and Mental Health of the Elderly: The Mediating Effect of Social Participation. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-13062-7"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Sandstr\u00f6m, N., Johansson, M., Jekunen, A., and Anders\u00e9n, H. (2023). Socioeconomic Status and Lifestyle Patterns in the Most Common Cancer Types-Community-Based Research. BMC Public Health, 23.","DOI":"10.1186\/s12889-023-16677-6"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Barakat, C., and Konstantinidis, T. (2023). A Review of the Relationship between Socioeconomic Status Change and Health. Int. J. Environ. Res. Public. Health, 20.","DOI":"10.3390\/ijerph20136249"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10654-020-00685-6","article-title":"SES Inequalities in Cause-Specific Adult Mortality: A Study of the Long-Term Trends Using Longitudinal Individual Data for Sweden (1813\u20132014)","volume":"35","author":"Debiasi","year":"2020","journal-title":"Eur. J. Epidemiol."},{"key":"ref_92","first-page":"3","article-title":"Extent and Socioeconomic Correlates of Small Area Variations in Life Expectancy in Canada and the United States","volume":"35","author":"Wolfson","year":"2024","journal-title":"Health Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8270810","DOI":"10.1155\/2020\/8270810","article-title":"Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts","volume":"2020","author":"Jalloh","year":"2020","journal-title":"J. Trop. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.3390\/curroncol31050192","article-title":"Income Disparities in Survival and Receipt of Neoadjuvant Chemotherapy and Pelvic Lymph Node Dissection for Muscle-Invasive Bladder Cancer","volume":"31","author":"Antar","year":"2024","journal-title":"Curr. Oncol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"722","DOI":"10.17269\/s41997-019-00227-y","article-title":"Trends in Socio-Economic Inequalities in Bladder Cancer Incidence in Canada: 1992\u20132010","volume":"110","author":"Densmore","year":"2019","journal-title":"Can. J. Public Health Rev. Can. Sant\u00e9 Publique"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Huang, Q., Yang, J., Liu, G.-X., Zi, H., Tang, S.-D., Jia, H.-C., Li, W., Xu, X.-F., and Zeng, X.-T. (2024). Changes in Disease Burden and Global Inequalities in Bladder, Kidney and Prostate Cancers from 1990 to 2019: A Comparative Analysis Based on the Global Burden of Disease Study 2019. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-18353-9"},{"key":"ref_97","first-page":"e24818","article-title":"Analysis of a Long Non-Coding RNA Associated Signature to Predict Survival in Patients with Bladder Cancer","volume":"14","author":"Zhong","year":"2022","journal-title":"Cureus"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"152429","DOI":"10.1016\/j.prp.2019.04.021","article-title":"Long Noncoding RNAs in Bladder Cancer Prognosis: A Meta-Analysis","volume":"215","author":"Zhu","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.1098119","article-title":"Ultraconserved Elements in the Human Genome","volume":"304","author":"Bejerano","year":"2004","journal-title":"Science"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Gibert, M.K., Sarkar, A., Chagari, B., Roig-Laboy, C., Saha, S., Bednarek, S., Kefas, B., Hanif, F., Hudson, K., and Dube, C. (2022). Transcribed Ultraconserved Regions in Cancer. Cells, 11.","DOI":"10.3390\/cells11101684"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"20636","DOI":"10.18632\/oncotarget.7833","article-title":"Long Non-Coding RNA Containing Ultraconserved Genomic Region 8 Promotes Bladder Cancer Tumorigenesis","volume":"7","author":"Olivieri","year":"2016","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ccr.2007.07.027","article-title":"Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas","volume":"12","author":"Calin","year":"2007","journal-title":"Cancer Cell"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Saginala, K., Barsouk, A., Aluru, J.S., Rawla, P., Padala, S.A., and Barsouk, A. (2020). Epidemiology of Bladder Cancer. Med. Sci., 8.","DOI":"10.3390\/medsci8010015"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Terreri, S., Durso, M., Colonna, V., Romanelli, A., Terracciano, D., Ferro, M., Perdon\u00e0, S., Castaldo, L., Febbraio, F., and de Nigris, F. (2016). New Cross-Talk Layer between Ultraconserved Non-Coding RNAs, MicroRNAs and Polycomb Protein YY1 in Bladder Cancer. Genes, 7.","DOI":"10.3390\/genes7120127"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Ciaramella, A., Di Nardo, E., Terracciano, D., Conte, L., Febbraio, F., and Cimmino, A. (2023). A New Biomarker Panel of Ultraconserved Long Non-Coding RNAs for Bladder Cancer Prognosis by a Machine Learning Based Methodology. BMC Bioinform., 23.","DOI":"10.1186\/s12859-023-05167-6"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Terreri, S., Mancinelli, S., Ferro, M., Vitale, M.C., Perdon\u00e0, S., Castaldo, L., Gigantino, V., Mercadante, V., De Cecio, R., and Aquino, G. (2021). Subcellular Localization of Uc.8+ as a Prognostic Biomarker in Bladder Cancer Tissue. Cancers, 13.","DOI":"10.3390\/cancers13040681"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/24\/7873\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:50:55Z","timestamp":1760115055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/24\/7873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":106,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["s24247873"],"URL":"https:\/\/doi.org\/10.3390\/s24247873","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]}}}