{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:10:36Z","timestamp":1783437036576,"version":"3.54.6"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R &amp; D Program of China","award":["2021YFF0306405"],"award-info":[{"award-number":["2021YFF0306405"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The early prediction of Alzheimer\u2019s disease (AD) risk in healthy individuals remains a significant challenge. This study investigates the feasibility of task-state EEG signals for improving detection accuracy. Electroencephalogram (EEG) data were collected from the Multi-Source Interference Task (MSIT) and Sternberg Memory Task (STMT). Time\u2013frequency features were extracted using the Multitaper method, followed by multidimensional reduction techniques. Subspace features (F24 and F216) were selected via t-tests and False Discovery Rate (FDR) multiple comparisons correction, and subsequently analyzed in the Time\u2013Frequency Area Average Test (TFAAT) and Prefrontal Beta Time Series Test (PBTST). The experimental results reveal that the MSIT task achieves optimal cross-subject classification performance using the Support Vector Machine (SVM) approach with the TFAAT feature set, yielding a Receiver Operating Characteristic Area Under the Curve (ROC AUC) of 58%. Similarly, the Sternberg Memory Task demonstrates classification ability with the logistic regression model applied to the PBTST feature set, emphasizing the beta band power spectrum in the prefrontal cortex as a potential marker of AD risk. These findings confirm that task-state EEG provides stronger classification potential compared to resting-state EEG, offering valuable insights for advancing early AD prediction research.<\/jats:p>","DOI":"10.3390\/s25010052","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:29:52Z","timestamp":1735154992000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring Task-Related EEG for Cross-Subject Early Alzheimer\u2019s Disease Susceptibility Prediction in Middle-Aged Adults Using Multitaper Spectral Analysis"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0371-6341","authenticated-orcid":false,"given":"Ziyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Automation, Northeastern University, Wenhua Street, Shenyang 110819, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7639-6967","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Automation, Northeastern University, Wenhua Street, Shenyang 110819, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Automation, Northeastern University, Wenhua Street, Shenyang 110819, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-4913","authenticated-orcid":false,"given":"Jiale","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Automation, Northeastern University, Wenhua Street, Shenyang 110819, China"},{"name":"Senzhigaoke Company Limited, Gaoke Street, Shenyang 110002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clinbiochem.2019.04.015","article-title":"Clinical aspects of Alzheimer\u2019s disease","volume":"72","year":"2019","journal-title":"Clin. 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