{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:42:17Z","timestamp":1759970537128,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft DFG SFB 1213","award":["B09"],"award-info":[{"award-number":["B09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>The initiation of sodium\u2013glucose cotransporter 2 (SGLT2) inhibitor treatment was shown to reduce pulmonary artery pressure (PAP) in New York Heart Association (NYHA) class III heart failure (HF) patients with an implanted PAP sensor. We aimed to investigate the impact of SGLT2-I initiation on pulmonary vascular resistance (PVR), pulmonary capillary wedge pressure (PCWP), pulmonary arterial capacitance (PAC), and right ventricle (RV) to PA (RV-PA) coupling in a pilot cohort of HF with preserved\/mildly reduced ejection fraction (HFpEF\/HFmrEF) patients and whether PVR and PCWP can be serially calculated non-invasively using PAP sensor data during follow-up. Methods: Right heart catheterization parameters (PVR, PCWP, and PAC) were obtained at sensor implantation and echocardiographic assessments (E\/E\u2019, RV-PA coupling, and RV cardiac output) were made at baseline and every 3 months. SGLT2 inhibition was initiated after 3 months of telemedical care. Three methods for calculating PVR and PCWP were compared using Bland\u2013Altman plots and Spearman\u2019s correlation. Results: In 13 HF patients (mean age 77 \u00b1 4 years), there were no significant changes in PAP, PVR, PCWP, RV-PA coupling, or PAC over 9 months (all p-values &gt; 0.05), including after SGLT2-I initiation. PVR values were closely correlated across the three methods (PVRNew and PVRNew Tedford (r = 0.614, p &lt; 0.001), PVREcho and PVRNew Tedford (r = 0.446, p = 0.006), and PVREcho and PVRNew (r = 0.394, p = 0.016)), but PCWP methods lacked reliable association (PCWPEcho and PCWPNew (r = 0.180, p = 0.332). Conclusions: No changes in cardiopulmonary hemodynamics were detected after hemodynamic telemonitoring either prior to or following SGLT2-I initiation. Different PVR assessment methods yielded comparable results, whereas PCWP methods were not associated with each other. Further investigations with larger cohorts including repeated right heart catheterization are planned.<\/jats:p>","DOI":"10.3390\/s25030605","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:47:42Z","timestamp":1737438462000},"page":"605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Series Evaluating the Relationship of SGLT2 Inhibition to Pulmonary Artery Pressure and Non-Invasive Cardiopulmonary Parameters in HFpEF\/HFmrEF Patients\u2014A Pilot Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-0282","authenticated-orcid":false,"given":"Ester Judith","family":"Herrmann","sequence":"first","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-3295","authenticated-orcid":false,"given":"Michael","family":"Guckert","sequence":"additional","affiliation":[{"name":"Institute of Mathematics, Natural Sciences and Data Processing, Technische Hochschule Mittelhessen\u2014University of Applied Sciences, 61169 Friedberg, Germany"},{"name":"Cognitive Information Systems Group, Kompetenzzentrum f\u00fcr Informationstechnologie (KITE), Technische Hochschule Mittelhessen\u2014University of Applied Sciences, 61169 Friedberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-636X","authenticated-orcid":false,"given":"Dimitri","family":"Gruen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-6491","authenticated-orcid":false,"given":"Till","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhein Main, 61231 Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5557-623X","authenticated-orcid":false,"given":"Khodr","family":"Tello","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Internal Medicine, Pneumology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-0894","authenticated-orcid":false,"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Internal Medicine, Pneumology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2673","authenticated-orcid":false,"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"},{"name":"Department of Internal Medicine I, Cardiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhein Main, 61231 Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-6444","authenticated-orcid":false,"given":"Birgit","family":"Assmus","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"},{"name":"Department of Internal Medicine I, Cardiology, Justus-Liebig-University Giessen, 35392 Giessen, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhein Main, 61231 Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur. 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