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Seventeen participants (eight females) completed a screening visit following a randomized controlled four-arm crossover trial period with 8 h of uninterrupted prolonged sitting, alternate sitting and standing, continuous standing, and continuous slow walking, respectively. Clinical inflammatory risk markers were obtained from venous blood samples, and PA was assessed using the International Physical Activity Questionnaire (IPAQ-SF) and ActiGraph wGT3X-BT accelerometers. HRV was recorded over 24 h using the Faros 180 Holter electrocardiogram (ECG). White blood cell (WBC) counts were significantly correlated with fat mass (FM; p = 0.03) and visceral adipose tissue (VAT; p = 0.04) and inversely correlated with moderate PA (p = 0.02). Light-intensity PA (LIPA) and moderate-to-vigorous PA (MVPA) were correlated with HRV parameters (p = 0.02), and LIPA was inversely correlated with interleukin-6 (p = 0.003) and c-reactive protein (p = 0.04) during different trial conditions. In university students with overweight and obesity, higher values of FM were negatively correlated with WBC count, and integrating LIPA and MVPA in the students\u2019 daily life strengthened their sympathetic\u2013parasympathetic regulation and positively mediated anti-inflammatory mechanisms.<\/jats:p>","DOI":"10.3390\/s25051510","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:12:33Z","timestamp":1740737553000},"page":"1510","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations Between Clinical Inflammatory Risk Markers, Body Composition, Heart Rate Variability, and Accelerometer-Assessed Physical Activity in University Students with Overweight and Obesity"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1458-2355","authenticated-orcid":false,"given":"Sascha W.","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Division of Theory and Practice of Sports and Fields of Physical Activity, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-9261","authenticated-orcid":false,"given":"Janis","family":"Schierbauer","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voit","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auguste","family":"Grothoff","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-3594","authenticated-orcid":false,"given":"Nadine","family":"Wachsmuth","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9543-8870","authenticated-orcid":false,"given":"Andreas","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Niedrist","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-3720","authenticated-orcid":false,"given":"Helmut K.","family":"Lackner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othmar","family":"Moser","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"},{"name":"Interdisciplinary Metabolic Medicine Trials Unit, Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Edelmann, D., Pfirrmann, D., Heller, S., Dietz, P., Reichel, J.L., Werner, A.M., Sch\u00e4fer, M., Tibubos, A.N., Deci, N., and Letzel, S. 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