{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:52:27Z","timestamp":1784253147473,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01AG071638"],"award-info":[{"award-number":["R01AG071638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01AG075728"],"award-info":[{"award-number":["R01AG075728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01AG056352"],"award-info":[{"award-number":["R01AG056352"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01AG079133"],"award-info":[{"award-number":["R01AG079133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01AG017917"],"award-info":[{"award-number":["R01AG017917"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Hemodynamic homeostasis is essential for adapting the heart rate (HR) to postural and physiological changes during daily activities. Traditional HR monitoring, such as 24 hour (h) Holter monitoring, provides important information on homeostasis during daily living. However, this approach lacks concurrent activity recording, limiting insights into hemodynamic adaptation and our ability to interpret changes in HR. To address this, we utilized a novel wearable sensor system (ANNE@Sibel) to capture time-locked HR and daily activity (i.e., lying, sitting, standing, walking) data in 105 community-dwelling older adults. We developed custom tools to extract 24 h time-locked measurements and introduced a \u201cheart rate response score\u201d (HRRS), based on root Jensen\u2013Shannon divergence, to quantify HR changes relative to activity. As expected, we found a progressive HR increase with more vigorous activities, though individual responses varied widely, highlighting heterogeneous HR adaptations. The HRRS (mean: 0.38 \u00b1 0.14; min: \u22120.11; max: 0.74) summarized person-specific HR changes and was correlated with several clinical measures, including systolic blood pressure changes during postural transitions (r = 0.325, p = 0.003), orthostatic hypotension status, and calcium channel blocker medication use. These findings demonstrate the potential of unobtrusive sensors in remote phenotyping as a means of providing valuable physiological and behavioral data to enhance the quantitative description of aging phenotypes. This approach could enhance personalized medicine by informing targeted interventions based on hemodynamic adaptations during everyday activities.<\/jats:p>","DOI":"10.3390\/s25061945","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T04:58:38Z","timestamp":1742533118000},"page":"1945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combining 24-Hour Continuous Monitoring of Time-Locked Heart Rate, Physical Activity and Gait in Older Adults: Preliminary Findings"],"prefix":"10.3390","volume":"25","author":[{"given":"Eitan E.","family":"Asher","sequence":"first","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Gazit","sequence":"additional","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Montazeri","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-4329","authenticated-orcid":false,"given":"Elisa","family":"Mej\u00eda-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-5393","authenticated-orcid":false,"given":"Veronique G.","family":"VanderHorst","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Movement Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2742","authenticated-orcid":false,"given":"Aron S.","family":"Buchman","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S. P.","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-0776","authenticated-orcid":false,"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel"},{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA"},{"name":"Department of Physical Therapy, Faculty of Medical & Health Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1007\/s11357-023-00815-4","article-title":"Remote monitoring technologies for mea-suring cardiovascular functions in community-dwelling adults: A systematic review","volume":"45","author":"Lu","year":"2023","journal-title":"Geroscience"},{"key":"ref_2","unstructured":"Hallgr\u00edmsson, H.T., Jankovic, F., Althoff, T., and Foschini, L. 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