{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:17:31Z","timestamp":1791303451901,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Electroencephalography is a widely used non-invasive method for monitoring brain electrical activity, critical for diagnosing and managing neurological disorders such as epilepsy. While clinical standards use 21 electrodes to capture comprehensive neural signals, a personalized approach can enhance performance by selecting patient-specific channels, reducing noise and redundancy. This study introduces an innovative, lightweight deep learning system optimized for real-time seizure detection in personalized wearable devices. The system uses an efficient Convolutional Neural Network that processes data from just two channels. These channels are automatically selected using a data-driven mechanism that identifies the most informative scalp regions based on each patient\u2019s unique seizure patterns. The proposed approach ensures high reliability, even with small datasets, and improves interpretability for clinicians by overcoming the limitations of more complex methods. The tailored channel selection boosts detection accuracy and ensures robust performance across different seizure types while reducing the computational burden typical of multi-electrode systems. Validation on the publicly available CHB-MIT dataset achieved an average balanced accuracy of 0.83 and a false-positive rate of approximately 0.1\/h. The system\u2019s performance matches, and in some cases outperforms, state-of-the-art systems that use four fixed channels in temporal regions, demonstrating the potential of two-channel wearable solutions, specifically with a non-negligible 30% reduction in the false-positive rate. This interpretable, patient-specific method enables the development of personalized, efficient, and compact wearable devices for reliable seizure detection in everyday life.<\/jats:p>","DOI":"10.3390\/s25092715","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:02:57Z","timestamp":1745568177000},"page":"2715","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Personalizing Seizure Detection for Individual Patients by Optimal Selection of EEG Signals"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-4848","authenticated-orcid":false,"given":"Rosanna","family":"Ferrara","sequence":"first","affiliation":[{"name":"Department of Information Engineering, Electrical Engineering and Applied Mathematics (DIEM), University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5010-3604","authenticated-orcid":false,"given":"Martino","family":"Giaquinto","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Electrical Engineering and Applied Mathematics (DIEM), University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-0353","authenticated-orcid":false,"given":"Gennaro","family":"Percannella","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Electrical Engineering and Applied Mathematics (DIEM), University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3341-5483","authenticated-orcid":false,"given":"Leonardo","family":"Rundo","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Electrical Engineering and Applied Mathematics (DIEM), University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-7994","authenticated-orcid":false,"given":"Alessia","family":"Saggese","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, Electrical Engineering and Applied Mathematics (DIEM), University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41528-021-00107-x","article-title":"Advances in healthcare wearable devices","volume":"5","author":"Iqbal","year":"2021","journal-title":"NPJ Flex. 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