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The recent literature has seen significant progress in the development of highly sensitive and selective fluorescent probes applicable for monitoring ONOO\u2212 dynamics in live cells and a variety of animal models of human diseases. However, the clinical applications of those probes remain much less explored. This review delves into the biological roles of ONOO\u2212 and summarizes the design strategies, sensing mechanisms, and bioimaging applications of near-infrared (NIR), long-wavelength, two-photon, and ratiometric fluorescent probes modified with a diverse range of functional groups responsive to ONOO\u2212. Furthermore, we will discuss the remaining problems that prevent the currently developed ONOO\u2212 probes from translating into clinical practice.<\/jats:p>","DOI":"10.3390\/s25103018","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T06:17:08Z","timestamp":1747030628000},"page":"3018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Recent Advancement in Fluorescent Probes for Peroxynitrite (ONOO\u2212)"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-3828","authenticated-orcid":false,"given":"Hai-Hao","family":"Han","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Materials and Joint International Research, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China"},{"name":"Laboratory of Precision Chemistry and Molecular 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(2024). Peroxynitrite: A multifaceted oxidizing and nitrating metabolite. Curr. Opin. Chem. Biol., 80.","DOI":"10.1016\/j.cbpa.2024.102459"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/15321819.2019.1583109","article-title":"Peroxynitrite: Cellular pathology and implications in autoimmunity","volume":"40","author":"Ahmad","year":"2019","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100787","DOI":"10.1016\/j.xcrm.2022.100787","article-title":"Peroxynitrite promotes immune evasion by reducing tumor antigenicity","volume":"3","author":"Capietto","year":"2022","journal-title":"Cell Rep. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.brainresbull.2017.05.008","article-title":"Cellular mechanisms of peroxynitrite-induced neuronal death","volume":"133","author":"Ramdial","year":"2017","journal-title":"Brain Res. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2018.02.017","article-title":"Fluorescence and chemiluminescence approaches for peroxynitrite detection","volume":"128","author":"Prolo","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrd2222","article-title":"Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Su, H., Wang, N., Wang, J., Wang, H., Zhang, J., and Zhao, W. (2021). A resorufin-based red-emitting fluorescent probe with high selectivity for tracking endogenous peroxynitrite in living cells and inflammatory mice. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 252.","DOI":"10.1016\/j.saa.2021.119502"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Liu, Z., Mo, S., Hao, Z., and Hu, L. (2023). Recent Progress of Spectroscopic Probes for Peroxynitrite and Their Potential Medical Diagnostic Applications. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612821"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1039\/D1AN00980J","article-title":"Construction of a near-infrared fluorescent probe for ratiometric imaging of peroxynitrite during tumor progression","volume":"146","author":"Li","year":"2021","journal-title":"Analyst"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/10715760410001659773","article-title":"Detection of superoxide and peroxynitrite in model systems and mitochondria by the luminol analogue L-012","volume":"38","author":"Daiber","year":"2004","journal-title":"Free Radic. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1002\/1521-3765(20011001)7:19<4171::AID-CHEM4171>3.0.CO;2-5","article-title":"Characterization of the electrochemical oxidation of peroxynitrite: Relevance to oxidative stress bursts measured at the single cell level","volume":"7","author":"Amatore","year":"2001","journal-title":"Chemistry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/01.CIR.99.5.690","article-title":"Noninvasive measurements of infarct size after thrombolysis with a necrosis-avid MRI contrast agent","volume":"99","author":"Pislaru","year":"1999","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12311","DOI":"10.1039\/C4CC04292A","article-title":"19F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction","volume":"50","author":"Bruemmer","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13629","DOI":"10.1039\/D4CC03452J","article-title":"Recent progress in organelle-targeting fluorescent probes for the detection of peroxynitrite","volume":"60","author":"Li","year":"2024","journal-title":"Chem. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"343443","DOI":"10.1016\/j.aca.2024.343443","article-title":"Peroxynitrite activatable NIR-II probe for tumor diagnosis and photothermal therapy in vivo","volume":"1335","author":"Xu","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aca.2020.02.009","article-title":"A fast detection of peroxynitrite in living cells","volume":"1106","author":"Li","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e202200828","DOI":"10.1002\/chem.202200828","article-title":"Recent Progress of Small-Molecule Ratiometric Fluorescent Probes for Peroxynitrite in Biological Systems","volume":"28","author":"Ma","year":"2022","journal-title":"Chem.\u2014A Eur. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2430157","DOI":"10.1080\/13510002.2024.2430157","article-title":"Fluorescent probes for sensing peroxynitrite: Biological applications","volume":"29","author":"Yang","year":"2024","journal-title":"Redox Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Grzelakowska, A., Kalyanaraman, B., and Zielonka, J. (2024). Small molecule probes for peroxynitrite detection. Redox Biochem. Chem., 10.","DOI":"10.1016\/j.rbc.2024.100034"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Li, M., Lei, P., Shuang, S., Dong, C., and Zhang, L. (2023). Recent advances in fluorescent probes for dual-detecting ONOO\u2212 and analytes. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 303.","DOI":"10.1016\/j.saa.2023.123179"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"19669","DOI":"10.1039\/D4SC06722C","article-title":"Recent progress in small-molecule fluorescent probes for the detection of superoxide anion, nitric oxide, and peroxynitrite anion in biological systems","volume":"15","author":"Zhou","year":"2024","journal-title":"Chem. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0891-5849(02)01111-5","article-title":"Peroxynitrite reactions and formation in mitochondria","volume":"33","author":"Radi","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1520-7560(199907\/08)15:4<283::AID-DMRR42>3.0.CO;2-U","article-title":"Nitric oxide and its role in lipid peroxidation","volume":"15","author":"Violi","year":"1999","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1093\/nar\/24.21.4105","article-title":"DNA damage by peroxynitrite characterized with DNA repair enzymes","volume":"24","author":"Epe","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/acs.chemrev.7b00568","article-title":"Biochemistry of Peroxynitrite and Protein Tyrosine Nitration","volume":"118","author":"Campolo","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1053\/gast.2003.50001","article-title":"Regulation of intestinal nuclear factor-kappaB activity and E-selectin expression during sepsis: A role for peroxynitrite","volume":"124","author":"Lush","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1152\/physrev.00005.2022","article-title":"The superoxide radical switch in the biology of nitric oxide and peroxynitrite","volume":"102","author":"Piacenza","year":"2022","journal-title":"Physiol. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0735-1097(19)31629-8","article-title":"N-Acetylcysteine Reverses Peroxynitrite and Hydrogen Peroxide-Induced Apoptosis of Human Myocardial Cells","volume":"73","author":"Liu","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1161\/01.CIR.96.7.2317","article-title":"Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium after ischemia and reperfusion in cats","volume":"96","author":"Nossuli","year":"1997","journal-title":"Circulation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.jacc.2004.01.047","article-title":"Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats","volume":"43","author":"Lancel","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0006-2952(97)00492-9","article-title":"Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus","volume":"55","author":"Rabinovitch","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/gut.46.3.436","article-title":"Peroxynitrite and inflammatory bowel disease","volume":"46","author":"McCafferty","year":"2000","journal-title":"Gut"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ccell.2022.09.001","article-title":"Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy","volume":"40","author":"Tcyganov","year":"2022","journal-title":"Cancer Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0173(99)00014-4","article-title":"Neurodegenerative disorders: The role of peroxynitrite","volume":"30","author":"Torreilles","year":"1999","journal-title":"Brain Res. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jhep.2020.04.033","article-title":"Danger signals in liver injury and restoration of homeostasis","volume":"73","author":"Han","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.chroma.2005.05.027","article-title":"Separation and detection of peroxynitrite and its metabolites by capillary electrophoresis with UV detection","volume":"1111","author":"Frankenfeld","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1039\/C0AN00625D","article-title":"GC-MS and HPLC methods for peroxynitrite (ONOO\u2212 and O15NOO\u2212) analysis: A study on stability, decomposition to nitrite and nitrate, laboratory synthesis, and formation of peroxynitrite from S-nitrosoglutathione (GSNO) and KO2","volume":"136","author":"Tsikas","year":"2011","journal-title":"Analyst"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.freeradbiomed.2022.05.001","article-title":"Peroxynitrous acid-modified extracellular matrix alters gene and protein expression in human coronary artery smooth muscle cells and induces a pro-inflammatory phenotype","volume":"186","author":"Jorgensen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1021\/acs.analchem.7b00503","article-title":"Observation of the Generation of ONOO\u2212 in Mitochondria under Various Stimuli with a Sensitive Fluorescence Probe","volume":"89","author":"Li","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1039\/D3TB02994H","article-title":"Shedding light on ONOO\u2212 detection: The emergence of a fast-response fluorescent probe for biological systems","volume":"12","author":"Wu","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"ref_44","first-page":"1","article-title":"Boron Chemistry: An Overview","volume":"Volume 1236","author":"DeFrancesco","year":"2016","journal-title":"Boron Chemistry: An Overview"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sikora, A., Zielonka, J., Debowska, K., Michalski, R., Smulik-Izydorczyk, R., Pieta, J., Podsiadly, R., Artelska, A., Pierzchala, K., and Kalyanaraman, B. (2020). Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology. Front. Chem., 8.","DOI":"10.3389\/fchem.2020.580899"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.freeradbiomed.2009.08.006","article-title":"Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite","volume":"47","author":"Sikora","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"130206","DOI":"10.1016\/j.snb.2021.130206","article-title":"Mitochondria-specific ultrasensitive ratiometric AIE probe for imaging endogenous peroxynitrite","volume":"344","author":"Guo","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"131393","DOI":"10.1016\/j.snb.2022.131393","article-title":"A near-infrared fluorescent probe for ratiometric imaging peroxynitrite in Parkinson\u2019s disease model","volume":"359","author":"Kang","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/open.201900301","article-title":"A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite","volume":"8","author":"Wu","year":"2019","journal-title":"ChemistryOpen"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1039\/C8CC06917D","article-title":"ESIPT-based fluorescence probe for the rapid detection of peroxynitrite \u2018AND\u2019 biological thiols","volume":"54","author":"Wu","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109371","DOI":"10.1016\/j.dyepig.2021.109371","article-title":"A water-soluble boronate masked benzoindocyanin fluorescent probe for the detection of endogenous mitochondrial peroxynitrite in live cells and zebrafish as inflammation models","volume":"191","author":"Sonawane","year":"2021","journal-title":"Dye. Pigment."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1007\/s00216-022-04307-w","article-title":"A benzothiazole-based fluorescence probe for imaging of peroxynitrite during ferroptosis and diagnosis of tumor tissues","volume":"414","author":"Ma","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_53","first-page":"3223","article-title":"Ratiometric Fluorescent Probe for Real-Time Detection of beta-Galactosidase Activity in Lysosomes and Its Application in Drug-Induced Senescence Imaging","volume":"96","author":"Liu","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"127564","DOI":"10.1016\/j.talanta.2025.127564","article-title":"A ratiometric fluorescent probe with dual near infrared emission for in vivo ratio imaging of cysteine","volume":"286","author":"Zheng","year":"2025","journal-title":"Talanta"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bios.2017.01.027","article-title":"In vitro and in vivo imaging of peroxynitrite by a ratiometric boronate-based fluorescent probe","volume":"91","author":"Palanisamy","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1021\/cr5004425","article-title":"Small-molecule two-photon probes for bioimaging applications","volume":"115","author":"Kim","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"20425","DOI":"10.1021\/acs.analchem.4c04103","article-title":"Cellular and Intravital Nucleus Imaging by a D-\u03c0-A Type of Red-Emitting Two-Photon Fluorescent Probe","volume":"96","author":"Duan","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2021.04.011","article-title":"Two-photon fluorescent probe for cellular peroxynitrite: Fluorescence detection, imaging, and identification of peroxynitrite-specific products","volume":"169","author":"Grzelakowska","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12822","DOI":"10.1039\/C7CC07845E","article-title":"Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite","volume":"53","author":"Sedgwick","year":"2017","journal-title":"Chem. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Tang, J., Li, Z., Qiang, C., Han, Y., Yang, L., Zhu, L., Dang, T., Chen, G., and Ye, Y. (2023). A long-wavelength mitochondria-targeted fluorescent probe for imaging of peroxynitrite during dexamethasone treatment. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 292.","DOI":"10.1016\/j.saa.2023.122429"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1021\/acs.analchem.3c05342","article-title":"Dual-Channel\/Localization Single-Molecule Fluorescence Probe for Monitoring ATP and HOCl in Early Diagnosis and Therapy of Rheumatoid Arthritis","volume":"96","author":"Qu","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1021\/jacs.1c07954","article-title":"Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5\u2032-triphosphate in Cellular Applications","volume":"144","author":"Wu","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e202409295","DOI":"10.1002\/anie.202409295","article-title":"Diaminonaphthalene Boronic Acid (DANBA): New Approach for Peroxynitrite Sensing Site","volume":"63","author":"Gong","year":"2024","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.1021\/acs.analchem.4c06983","article-title":"Phenyl Radical-Mediated Fluorogenic Cyclization for Specific Detection of Peroxynitrite","volume":"97","author":"Grzelakowska","year":"2025","journal-title":"Anal. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"130609","DOI":"10.1016\/j.snb.2021.130609","article-title":"Unimolecular chemo-fluoro-luminescent probe for simultaneous detection and imaging of peroxynitrite and hypochlorite in vitro and in vivo","volume":"347","author":"Zhang","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"121607","DOI":"10.1016\/j.talanta.2020.121607","article-title":"A two-photon excited near-infrared fluorescent probe for imaging peroxynitrite during drug-induced hepatotoxicity and its remediation","volume":"221","author":"Mao","year":"2021","journal-title":"Talanta"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1039\/C9AN00347A","article-title":"A highly selective and sensitive red-emitting fluorescent probe for visualization of endogenous peroxynitrite in living cells and zebrafish","volume":"144","author":"Li","year":"2019","journal-title":"Analyst"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Hu, J., Rong, X., Jiang, J., Wang, Y., Zhang, X., Xu, Z., Xu, K., Wu, M., and Fang, M. (2024). Development of a hybrid rhodamine-hydrazine NIR fluorescent probe for sensitive detection and imaging of peroxynitrite in necrotizing enterocolitis model. Bioorg. Chem., 152.","DOI":"10.1016\/j.bioorg.2024.107729"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10924","DOI":"10.1021\/acs.analchem.7b02707","article-title":"A Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues","volume":"89","author":"Wu","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"17485","DOI":"10.1021\/acs.analchem.2c03661","article-title":"Rational Design of a Dual-Channel Fluorescent Probe for the Simultaneous Imaging of Hypochlorous Acid and Peroxynitrite in Living Organisms","volume":"94","author":"Huang","year":"2022","journal-title":"Anal. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yang, C., and Wang, X. (2021). Lysosome biogenesis: Regulation and functions. J. Cell Biol., 220.","DOI":"10.1083\/jcb.202102001"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1016\/j.cell.2023.09.027","article-title":"Nutrient-regulated control of lysosome function by signaling lipid conversion","volume":"186","author":"Ebner","year":"2023","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: A control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.aca.2019.11.065","article-title":"An efficient TP-FRET-based lysosome-targetable fluorescent probe for imaging peroxynitrite with two well-resolved emission channels in living cells, tissues and zebrafish","volume":"1100","author":"Sun","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Shang, J., Yang, Y., Sun, Y., Gao, W., Ma, K., Wang, C., Yu, X., Li, L., Zheng, J., and Zhao, N. (2025). Real-time monitoring of ONOO\u2212 in cerebral ischemia-reperfusion injury mouse models using a hydrazine-based NIR fluorescent probe. Redox Biol., 80.","DOI":"10.1016\/j.redox.2025.103494"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"132352","DOI":"10.1016\/j.snb.2022.132352","article-title":"A novel Golgi-targetable fluorescent probe for imaging peroxynitrite in Golgi stress and sepsis-induced acute lung injury","volume":"369","author":"Yan","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110345","DOI":"10.1016\/j.dyepig.2022.110345","article-title":"An activatable reporter for fluorescence imaging drug-induced liver injury in diverse cell lines and in vivo","volume":"203","author":"Qin","year":"2022","journal-title":"Dye. Pigment."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.talanta.2019.01.065","article-title":"Construction of a novel far-red fluorescence light-up probe for visualizing intracellular peroxynitrite","volume":"197","author":"Qu","year":"2019","journal-title":"Talanta"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Li, X., Zou, X., Xu, P., Pang, M., Zhao, L., Chen, S., Peng, Y., Liang, S., and Deng, Z. (2023). A robust NIR fluorescence-activated probe for peroxynitrite imaging in cells and mice osteoarthritis models. Anal. Biochem., 682.","DOI":"10.1016\/j.ab.2023.115338"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"11629","DOI":"10.1021\/acs.analchem.8b03207","article-title":"Mitochondrial Peroxynitrite Mediation of Anthracycline-Induced Cardiotoxicity as Visualized by a Two-Photon Near-Infrared Fluorescent Probe","volume":"90","author":"Xie","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1039\/C7SC00303J","article-title":"Two-photon fluorescent probe for revealing drug-induced hepatotoxicity via mapping fluctuation of peroxynitrite","volume":"8","author":"Li","year":"2017","journal-title":"Chem. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"128064","DOI":"10.1016\/j.talanta.2025.128064","article-title":"An \u03b1-ketoamide-based fluorescent probe via aggregation induced emission for ONOO\u2212 detection in vivo","volume":"293","author":"Yan","year":"2025","journal-title":"Talanta"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"121354","DOI":"10.1016\/j.talanta.2020.121354","article-title":"A long-wavelength turn-on fluorescent probe for intracellular nanomolar level peroxynitrite sensing with second-level response","volume":"219","author":"Zhang","year":"2020","journal-title":"Talanta"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1039\/D3SC05010F","article-title":"Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury","volume":"15","author":"Wu","year":"2024","journal-title":"Chem. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41467-017-01137-8","article-title":"Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1002\/adma.201300187","article-title":"Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite","volume":"25","author":"Zhang","year":"2013","journal-title":"Adv. Mater."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"18005","DOI":"10.1021\/jacs.0c05379","article-title":"Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers","volume":"142","author":"Chai","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1021\/jacs.8b05425","article-title":"Photocontrolled Fluorescence \u201cDouble-Check\u201d Bioimaging Enabled by a Glycoprobe\u2013Protein Hybrid","volume":"140","author":"Fu","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.1002\/adma.201602748","article-title":"Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet","volume":"28","author":"Ji","year":"2016","journal-title":"Adv. Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"127866","DOI":"10.1016\/j.talanta.2025.127866","article-title":"A lysosomal-targeted switchable fluorescent probe for the detection of peroxynitrite in living tumor cells and in vivo","volume":"291","author":"Jiang","year":"2025","journal-title":"Talanta"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1039\/C9CC09652C","article-title":"Observation of peroxynitrite overproduction in cells during 5-fluorouracil treatment via a ratiometric fluorescent probe","volume":"56","author":"Hou","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/asia.201700527","article-title":"Thiomaleimide Functionalization for Selective Biological Fluorescence Detection of Peroxynitrite as Tested in HeLa and RAW 264.7 Cells","volume":"12","author":"Yudhistira","year":"2017","journal-title":"Chem. Asian J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/chem.200802054","article-title":"A ratiometric fluorescent probe for hypochlorite based on a deoximation reaction","volume":"15","author":"Lin","year":"2009","journal-title":"Chemistry"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"123007","DOI":"10.1016\/j.talanta.2021.123007","article-title":"Visualization of peroxynitrite in cyclophosphamide-induced oxidative stress by an activatable probe","volume":"238","author":"Li","year":"2022","journal-title":"Talanta"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/abbi.2001.2540","article-title":"Evidence for Peroxynitrite-Mediated Modifications to p53 in Human Gliomas: Possible Functional Consequences","volume":"394","author":"Cobbs","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"134502","DOI":"10.1016\/j.snb.2023.134502","article-title":"Real-time diagnosis of glioblastoma by sensing peroxynitrite with a highly selective and rapid-responding fluorescent probe","volume":"395","author":"Zhang","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"15790","DOI":"10.1021\/acs.analchem.2c03577","article-title":"Dual-Channel Fluorescent Probe for the Detection of Peroxynitrite and Glutathione in Mitochondria: Accurate Discrimination of Inflammatory and Progressing Tumor Cells","volume":"94","author":"Luo","year":"2022","journal-title":"Anal. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"135909","DOI":"10.1016\/j.snb.2024.135909","article-title":"Three-channel fluorescent probe for real-time monitoring mitochondrial viscosity during mitophagy and visualizing ONOO\u2212\/SO2 in rheumatoid arthritis mice","volume":"413","author":"Li","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"112566","DOI":"10.1016\/j.microc.2024.112566","article-title":"A hepatocyte-targeting ratiometric fluorescence probe for monitoring peroxynitrite in liver injury","volume":"208","author":"Li","year":"2025","journal-title":"Microchem. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1021\/acssensors.4c02841","article-title":"A Novel \u201cDouble-Responsive\u201d and \u201cDual-Targeted\u201d Multifunctional Fluorescent Probe Monitors the Level Changes of ONOO\u2212 in Mitochondria during Cell Pyroptosis","volume":"10","author":"Wei","year":"2025","journal-title":"ACS Sens."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"127928","DOI":"10.1016\/j.talanta.2025.127928","article-title":"An activatable \u03b2-diketonate europium(III) complex-based probe for time-gated luminescence detection and imaging of peroxynitrite in vitro and in vivo","volume":"292","author":"Zou","year":"2025","journal-title":"Talanta"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Wang, C., Shu, W., Chen, Q., Yang, C., Su, S., Gao, M., Zhang, R., Jing, J., and Zhang, X. (2021). A simple dual-response fluorescent probe for imaging of viscosity and ONOO\u2212 through different fluorescence signals in living cells and zebrafish. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 260.","DOI":"10.1016\/j.saa.2021.119990"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Liang, C., Shu, W., Han, R., Kang, H., Zhang, X., Jing, J., Zhang, R., and Zhang, X. (2022). A xanthene-based fluorescent probe for detection of peroxynitrite in living cells and zebrafish. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 277.","DOI":"10.1016\/j.saa.2022.121264"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1021\/jo991126l","article-title":"A new thiatriazine isomer: Synthesis, tautomerism, and molecular structure of 3,6-diphenyl-4H-1,2,4,5-thiatriazine as a precursor to the 1,2,4,5-thiatriazinyl radical","volume":"65","author":"Farrar","year":"2000","journal-title":"J. Org. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1021\/ja0603756","article-title":"A highly selective fluorescent probe for the detection and imaging of peroxynitrite in living cells","volume":"128","author":"Yang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"9301","DOI":"10.1021\/acs.analchem.8b01879","article-title":"A Dual-Modal Molecular Probe for Near-Infrared Fluorescence and Photoacoustic Imaging of Peroxynitrite","volume":"90","author":"Zhang","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1039\/C8SC01865K","article-title":"Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis","volume":"9","author":"Cheng","year":"2018","journal-title":"Chem. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"132410","DOI":"10.1016\/j.snb.2022.132410","article-title":"Molecular fluorescent probes for imaging and evaluation of peroxynitrite fluctuations in living cells and in vivo under hypoxic stress","volume":"370","author":"Huang","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1021\/ol102182j","article-title":"HKGreen-3: A rhodol-based fluorescent probe for peroxynitrite","volume":"12","author":"Peng","year":"2010","journal-title":"Org. Lett."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"11728","DOI":"10.1021\/ja504624q","article-title":"Molecular imaging of peroxynitrite with HKGreen-4 in live cells and tissues","volume":"136","author":"Peng","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.snb.2018.01.203","article-title":"A simple highly selective and sensitive hydroquinone-based two-photon fluorescent probe for imaging peroxynitrite in live cells","volume":"262","author":"Zhu","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.snb.2019.03.068","article-title":"A novel hepatoma-specific fluorescent probe for imaging endogenous peroxynitrite in live HepG2 cells","volume":"289","author":"Liu","year":"2019","journal-title":"Sens. Actuators B Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"136114","DOI":"10.1016\/j.snb.2024.136114","article-title":"Rational construction of a novel fluorescent probe for imaging peroxynitrite in the endoplasmic reticulum during drug-induced liver injury","volume":"417","author":"Liu","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"127408","DOI":"10.1016\/j.talanta.2024.127408","article-title":"A sequence-activatable dual-locked fluorescent probe for simultaneous detection of hypochlorous acid and peroxynitrite during drug-induced liver injury","volume":"285","author":"Liu","year":"2025","journal-title":"Talanta"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"111209","DOI":"10.1016\/j.microc.2024.111209","article-title":"A highly sensitive and specific fluorescent probe for detecting ONOO\u2212 in liver-injured cells and tissues","volume":"205","author":"Wei","year":"2024","journal-title":"Microchem. J."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1021\/jacs.6b10508","article-title":"Selective Visualization of the Endogenous Peroxynitrite in an Inflamed Mouse Model by a Mitochondria-Targetable Two-Photon Ratiometric Fluorescent Probe","volume":"139","author":"Cheng","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"8246","DOI":"10.1039\/D1TB01534F","article-title":"A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury","volume":"9","author":"Gong","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1021\/acsabm.2c00213","article-title":"Piperazine-Based Mitochondria-Immobilized pH Fluorescent Probe for Imaging Endogenous ONOO\u2212 and Real-Time Tracking of Mitophagy","volume":"5","author":"Li","year":"2022","journal-title":"ACS Appl. Bio. Mater."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Sun, N., Cai, Y., Yan, H., Yang, W., and Hu, Y. (2024). Development of a ratiometric fluorescent probe for the detection of peroxynitrite. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 317.","DOI":"10.1016\/j.saa.2024.124404"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0039-9140(02)00120-0","article-title":"Development of a novel rhodamine-type fluorescent probe to determine peroxynitrite","volume":"57","author":"Yang","year":"2002","journal-title":"Talanta"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1021\/acs.analchem.7b01671","article-title":"Investigation of Drug-Induced Hepatotoxicity and Its Remediation Pathway with Reaction-Based Fluorescent Probes","volume":"89","author":"Cheng","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1021\/acs.analchem.8b00198","article-title":"A Bioluminescent Probe for Imaging Endogenous Peroxynitrite in Living Cells and Mice","volume":"90","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1039\/C7TB02615C","article-title":"A lysosome targetable versatile fluorescent probe for imaging viscosity and peroxynitrite with different fluorescence signals in living cells","volume":"6","author":"Guo","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"9347","DOI":"10.1021\/acs.analchem.8b01960","article-title":"A Two-Photon Fluorescent Probe for Imaging Endogenous ONOO\u2212 near NMDA Receptors in Neuronal Cells and Hippocampal Tissues","volume":"90","author":"Lee","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2410030","DOI":"10.1002\/smll.202410030","article-title":"Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases","volume":"21","author":"Dai","year":"2025","journal-title":"Small"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"125526","DOI":"10.1016\/j.talanta.2023.125526","article-title":"The development of logic gate-based fluorescent probes that respond to intracellular hydrogen peroxide and pH in tandem","volume":"270","author":"Han","year":"2024","journal-title":"Talanta"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1021\/acs.analchem.3c00007","article-title":"A Highly Sensitive and Selective Near-Infrared Fluorescent Probe for Imaging Peroxynitrite in Living Cells and Drug-Induced Liver Injury Mice","volume":"95","author":"Chai","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1039\/D0CS01183E","article-title":"Small-molecule fluorescence-based probes for interrogating major organ diseases","volume":"50","author":"Han","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"20161","DOI":"10.1021\/acs.analchem.4c03759","article-title":"A Mitochondria-Targeting and Peroxynitrite-Activatable Ratiometric Fluorescent Probe for Precise Tracking of Oxidative Stress-Induced Mitophagy","volume":"96","author":"Chai","year":"2024","journal-title":"Anal. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1039\/D2CS00673A","article-title":"The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy","volume":"52","author":"Han","year":"2023","journal-title":"Chem. Soc. Rev."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/25\/10\/3018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:30:40Z","timestamp":1760031040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/25\/10\/3018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":130,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["s25103018"],"URL":"https:\/\/doi.org\/10.3390\/s25103018","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]}}}