{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:32:33Z","timestamp":1782171153618,"version":"3.54.5"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014NextGenerationEU and by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), Mission 4, Component 2, Investment 1.5, project \u201cRAISE\u2014Robotics and AI for Socio-economic Empowerment\u201d","award":["ECS00000035"],"award-info":[{"award-number":["ECS00000035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>(1) Background: Technological advancements provide new opportunities to objectively assess motor deficits in people with Multiple Sclerosis (PwMS). This pilot study aimed to evaluate the performance and usability of iFeel, a novel wearable system which integrates inertial sensors, instrumented shoes, and an AI-based algorithm. (2) Methods: Sixteen adult PwMS (Expanded Disability Status Scale\u2014EDSS \u2264 6) performed motor tests (Timed 25-Foot Walk\u2014T25FW; Timed Up and Go\u2014TUG) both with and without the iFeel suit. Patient-reported outcomes (PROs) were also collected to assess perceived fatigue, dual-task impact, and walking difficulties. System Usability Scale (SUS) and ad hoc questionnaires have been further administered to test usability. (3) Results: No significant differences were found between the clinician and system-based scores for both T25FW (p = 0.383) and TUG (p = 0.447). Reliability analyses showed good agreement for T25FW (Intraclass Correlation Coefficient\u2014ICC = 0.83) and excellent agreement for TUG (ICC = 0.92). Sensor-derived measures correlated strongly with PROs on fatigue, dual-task interference, and mobility. Usability was rated high (SUS: 78.6 \u00b1 16.1), with participants reporting minimal discomfort and positive perceptions of iFeel usefulness for rehabilitation, health monitoring, and daily activities. (4) Conclusions: This pilot study provides preliminary yet promising evidence on the feasibility, usability, and perceived usefulness of the iFeel technology for motor assessment in PwMS. The findings support its further development and potential integration into clinical practice, particularly for remote or continuous motor monitoring.<\/jats:p>","DOI":"10.3390\/s25196214","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:48:30Z","timestamp":1759852110000},"page":"6214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Whole-Body Wearable Technology for Motor Assessment in Multiple Sclerosis: Feasibility and Usability Pilot Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-9148","authenticated-orcid":false,"given":"Jessica","family":"Podda","sequence":"first","affiliation":[{"name":"neuroBRITE Research Center, Italian Multiple Sclerosis Foundation, 16149 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5114-9276","authenticated-orcid":false,"given":"Erica","family":"Grange","sequence":"additional","affiliation":[{"name":"neuroBRITE Research Center, Italian Multiple Sclerosis Foundation, 16149 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-4588","authenticated-orcid":false,"given":"Claudia","family":"Latella","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-7315","authenticated-orcid":false,"given":"Andrea","family":"Tacchino","sequence":"additional","affiliation":[{"name":"neuroBRITE Research Center, Italian Multiple Sclerosis Foundation, 16149 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0126-453X","authenticated-orcid":false,"given":"Enrico","family":"Valli","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Danovaro","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4012-7415","authenticated-orcid":false,"given":"Gianluca","family":"Milani","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Forleo","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-1743","authenticated-orcid":false,"given":"Antonella","family":"Tatarelli","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Gorbani","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-4260","authenticated-orcid":false,"given":"Alex","family":"Coppola","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Pedull\u00e0","sequence":"additional","affiliation":[{"name":"neuroBRITE Research Center, Italian Multiple Sclerosis Foundation, 16149 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-3572","authenticated-orcid":false,"given":"Giampaolo","family":"Brichetto","sequence":"additional","affiliation":[{"name":"neuroBRITE Research Center, Italian Multiple Sclerosis Foundation, 16149 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Pucci","sequence":"additional","affiliation":[{"name":"Artificial and Mechanical Intelligence laboratory, Italian Institute of Technology, 16163 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., and Rocca, M.A. (2018). 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