{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:09:19Z","timestamp":1787904559377,"version":"build-2784847793"},"reference-count":65,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>To date, visual analysis is mainly used to evaluate images of dehydrated films (facies) of biological fluids\u2014microscopy at various magnifications, illumination with white or polarized light, as well as using a dark field. At the same time, important information on the architectonics of optically anisotropic supramolecular networks of facies is unknown (inaccessible). In our work, a model of optical anisotropy of the architectonics of supramolecular networks of blood facies is proposed. Algorithms and a methodology for a new multifunctional method of polarization-interference visualization of the Jones matrix and digital layer-by-layer phase reconstruction of optical anisotropy maps (theziograms) have been developed. As a result, statistically significant markers of oncological changes in the polycrystalline architectonics of supramolecular networks of blood facies samples from healthy donors and patients with papillary thyroid cancer at different stages of the oncological process have been determined and physically analyzed. A comparative study of the diagnostic efficiency of Jones matrix theziography (JT) and Mueller matrix diffusion tomography (MDT) of blood facies samples was conducted within the framework of evidence-based medicine. The main advantages of the Jones matrix method are shown: its multifunctionality (complex detection of birefringence and dichroism), high accuracy of early (stage 1: JM\u201490.4% and MDT\u201478.8%) and current (stage 2: JM\u201496.2% and MDT\u201488.5%) cancer diagnostics and an excellent level (JM\u201494.2% and MDT\u201484.6%) of differentiation of papillary thyroid cancer stages.<\/jats:p>","DOI":"10.3390\/s25206262","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:47:08Z","timestamp":1760104028000},"page":"6262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polarization-Interference Jones Matrix Sensors of Layer-by-Layer Scanning of Polycrystalline Dehydrated Blood Films. Fundamental and Applied Aspects"],"prefix":"10.3390","volume":"25","author":[{"given":"Oleksandr","family":"Ushenko","sequence":"first","affiliation":[{"name":"Institute of Zhejiang University-Taizhou, Taizhou 318000, China"},{"name":"Optics and Publishing Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Ushenko","sequence":"additional","affiliation":[{"name":"Department of Physics, Shaoxing University, Shaoxing 312399, China"},{"name":"Computer Science Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olexander","family":"Bilookyi","sequence":"additional","affiliation":[{"name":"Department of Surgery No. 1, Bucovinian State Medical University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-2811","authenticated-orcid":false,"given":"Alexander","family":"Dubolazov","sequence":"additional","affiliation":[{"name":"Optics and Publishing Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-288X","authenticated-orcid":false,"given":"Mykhaylo","family":"Gorsky","sequence":"additional","affiliation":[{"name":"Computer Science Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-7404","authenticated-orcid":false,"given":"Iryna","family":"Soltys","sequence":"additional","affiliation":[{"name":"Optics and Publishing Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-9190","authenticated-orcid":false,"given":"Yuriy","family":"Rohovy","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Bucovinian State Medical University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-7178","authenticated-orcid":false,"given":"Viacheslav","family":"Bilookyi","sequence":"additional","affiliation":[{"name":"Department of Surgery No. 1, Bucovinian State Medical University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pavlyukovich","sequence":"additional","affiliation":[{"name":"Departament of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Bucovinian State Medical University, 58000 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Mikirin","sequence":"additional","affiliation":[{"name":"Optics and Publishing Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Salega","sequence":"additional","affiliation":[{"name":"Optics and Publishing Department, Chernivtsi National University, 58012 Chernivtsi, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Bin","sequence":"additional","affiliation":[{"name":"College of Optical Science and Engineering, Zhejiang University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Zhejiang University-Taizhou, Taizhou 318000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"ref_1","unstructured":"Hunter, R. 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