{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:13:36Z","timestamp":1776154416105,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Multiple sclerosis is an inflammatory and neurodegenerative disease that leads to motor, cognitive, and sensory impairments, significantly affecting walking and quality of life. This study aimed to analyze the relationship between quality of life and kinematic walking parameters in individuals with multiple sclerosis, as well as to evaluate the influence of fatigue, balance, and cognitive performance on different aspects of quality of life. A cross-sectional observational study was conducted with 32 patients diagnosed with multiple sclerosis with Expanded Disability Status Scale scores of \u22645.5. Quality of life was assessed using the MusiQoL questionnaire, and clinical variables included fatigue (Fatigue Scale for Motor and Cognitive Functions, Borg scale), balance (Berg Balance Scale), and cognitive performance (Trail Making Test). Walking kinematics were analyzed using the Vicon motion capture system to obtain walking speed, step frequency, and joint asymmetry indices. Spearman correlations and linear regression models were applied. Results showed significant correlations between quality of life and walking speed (rho = 0.506), step frequency (rho = 0.508), and knee asymmetry (rho = \u22120.525), as well as strong associations with cognitive fatigue (rho = \u22120.796) and balance (rho = 0.635). Regression models explained up to 58.4% of the variance in the Activities of Daily Living dimension. These findings indicate that quality of life in multiple sclerosis is influenced by both clinical and biomechanical factors, highlighting the importance of comprehensive assessments to guide physiotherapeutic interventions.<\/jats:p>","DOI":"10.3390\/s25226909","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:49:43Z","timestamp":1763120983000},"page":"6909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gait Kinematics Assessed by Vicon\u00ae and Quality of Life Correlations in Multiple Sclerosis Patients: A Cross-Sectional Study"],"prefix":"10.3390","volume":"25","author":[{"given":"Oph\u00e9lie","family":"Micolas","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gil-Gregorio","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane-Miren","family":"Ur\u00eda-Oruez\u00e1bal","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7869-2782","authenticated-orcid":false,"given":"Ra\u00fal","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Sports Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7215-3925","authenticated-orcid":false,"given":"\u00c1ngel","family":"Gonz\u00e1lez-de-la-Flor","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-4095","authenticated-orcid":false,"given":"Mar\u00eda-Jos\u00e9","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-3999","authenticated-orcid":false,"given":"Mar\u00eda","family":"Garc\u00eda-Arrab\u00e9","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-2952","authenticated-orcid":false,"given":"Cecilia","family":"Estrada-Barranco","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Villaviciosa de Od\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mohammed, E.M.A. (2024). Understanding Multiple Sclerosis Pathophysiology and Current Disease-Modifying Therapies: A Review of Unaddressed Aspects. Front. Biosci., 29.","DOI":"10.31083\/j.fbl2911386"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pathog.2016.04.001","article-title":"Multiple sclerosis is prominent in the Gulf states: Review","volume":"3","author":"Mohammed","year":"2016","journal-title":"Pathogenesis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple sclerosis\u2014A review","volume":"26","author":"Dobson","year":"2019","journal-title":"Euro. J. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113021","DOI":"10.1016\/j.intimp.2024.113021","article-title":"NINJ1: A new player in multiple sclerosis pathogenesis and potential therapeutic target","volume":"141","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"a028936","DOI":"10.1101\/cshperspect.a028936","article-title":"Multiple Sclerosis Pathology","volume":"8","author":"Lassmann","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.cell.2023.03.008","article-title":"Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting","volume":"186","author":"Charabati","year":"2023","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e37297","DOI":"10.1097\/MD.0000000000037297","article-title":"Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment","volume":"103","author":"Haki","year":"2024","journal-title":"Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"A387","DOI":"10.1016\/j.autrev.2009.11.010","article-title":"Multiple sclerosis: Geoepidemiology, genetics and the environment","volume":"9","author":"Milo","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_9","first-page":"e18487","article-title":"Impact of Vitamin D Supplementation on Multiple Sclerosis","volume":"13","author":"Gandhi","year":"2021","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Brynedal, B., Duvefelt, K., Jonasdottir, G., Roos, I.M., \u00c5kesson, E., Palmgren, J., and Hillert, J. (2007). HLA-A Confers an HLA-DRB1 Independent Influence on the Risk of Multiple Sclerosis. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000664"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/jnnp-2024-334062","article-title":"Vitamin D affects the risk of disease activity in multiple sclerosis","volume":"96","author":"Giordano","year":"2025","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Schreiner, T.G., and Genes, T.M. (2021). Obesity and Multiple Sclerosis\u2014A Multifaceted Association. J. Clin. Med., 10.","DOI":"10.3390\/jcm10122689"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.amjmed.2020.03.008","article-title":"Multiple Sclerosis and Smoking","volume":"133","author":"Arneth","year":"2020","journal-title":"Am. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jakimovski, D., Weinstock-Guttman, B., Ramanathan, M., Dwyer, M.G., and Zivadinov, R. (2020). Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective. Vaccines, 8.","DOI":"10.3390\/vaccines8010050"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev.med.53.082901.103909","article-title":"Multiple Sclerosis","volume":"53","author":"Keegan","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e20211488","DOI":"10.1084\/jem.20211488","article-title":"The X factor in neurodegeneration","volume":"219","author":"Voskuhl","year":"2022","journal-title":"J. Exp. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"ref_19","first-page":"645197","article-title":"Gait Variability and Multiple Sclerosis","volume":"2013","author":"Socie","year":"2013","journal-title":"Mult. Scler. Int."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Weiland, T.J., Jelinek, G.A., Marck, C.H., Hadgkiss, E.J., van der Meer, D.M., Pereira, N.G., and Taylor, K.L. (2015). Clinically Significant Fatigue: Prevalence and Associated Factors in an International Sample of Adults with Multiple Sclerosis Recruited via the Internet. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0115541"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/135245859900500510","article-title":"Gait abnormalities in minimally impaired multiple sclerosis patients","volume":"5","author":"Benedetti","year":"1999","journal-title":"Mult. Scler."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/1545968314532835","article-title":"The Impact of Dynamic Balance Measures on Walking Performance in Multiple Sclerosis","volume":"29","author":"Fritz","year":"2015","journal-title":"Neurorehabilit. Neural Repair"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3233\/BMR-170925","article-title":"Morphofunctional muscle changes influence on foot stability in multiple sclerosis during gait prediction: The rehabilitation potential","volume":"31","author":"Neamtu","year":"2018","journal-title":"BMR"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Huang, S.C., Guerrieri, S., Dalla Costa, G., Pisa, M., Leccabue, G., Gregoris, L., Comi, G., and Leocani, L. (2022). Intensive Neurorehabilitation and Gait Improvement in Progressive Multiple Sclerosis: Clinical, Kinematic and Electromyographic Analysis. Brain Sci., 12.","DOI":"10.3390\/brainsci12020258"},{"key":"ref_25","first-page":"15","article-title":"Quantitative parameters of gait imbalance in multiple sclerosis patients","volume":"24","author":"Malinowska","year":"2022","journal-title":"Acta Bioeng. Biomech."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Inojosa, H., Schriefer, D., Kl\u00f6ditz, A., Trentzsch, K., and Ziemssen, T. (2020). Balance Testing in Multiple Sclerosis\u2014Improving Neurological Assessment with Static. Posturography?. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00135"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s10072-024-07318-w","article-title":"Usefulness of the Berg Balance Scale for prediction of fall risk in multiple sclerosis","volume":"45","author":"Ayvat","year":"2024","journal-title":"Neurol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jns.2015.09.352","article-title":"Effect of spasticity on kinematics of gait and muscular activation in people with Multiple Sclerosis","volume":"358","author":"Pau","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5334\/pb.1125","article-title":"The Complex Interplay Between Trait Fatigue and Cognition in Multiple Sclerosis","volume":"62","author":"Guillemin","year":"2022","journal-title":"Psychol. Belg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez, O., Fern\u00e1ndez, V., Baumstarck-Barrau, K., Mu\u00f1oz, L., Gonzalez Alvarez, M.D., Arrabal, J.C., Le\u00f3n, A., Alonso, A., L\u00f3pez-Madrona, J.C., and Bustamante, R. (2011). Validation of the spanish version of the multiple sclerosis international quality of life (musiqol) questionnaire. BMC Neurol., 11.","DOI":"10.1186\/1471-2377-11-127"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102986","DOI":"10.1016\/j.msard.2021.102986","article-title":"Sensorimotor function does not predict quality of life in persons with multiple sclerosis","volume":"52","author":"Gulde","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/17434440.2017.1386550","article-title":"Motion sensors in multiple sclerosis: Narrative review and update of applications","volume":"14","author":"Sasaki","year":"2017","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Drebinger, D., Rasche, L., Kroneberg, D., Althoff, P., Bellmann-Strobl, J., Weygandt, M., Paul, F., Brandt, A.U., and Schmitz-H\u00fcbsch, T. (2020). Association Between Fatigue and Motor Exertion in Patients with Multiple Sclerosis\u2014A Prospective Study. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00208"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jonsdottir, J., Lencioni, T., Gervasoni, E., Crippa, A., Anastasi, D., Carpinella, I., Rovaris, M., Cattaneo, D., and Ferrarin, M. (2020). Improved Gait of Persons with Multiple Sclerosis After Rehabilitation: Effects on Lower Limb Muscle Synergies, Push-Off, and Toe-Clearance. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00668"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0167-9457(91)90046-Z","article-title":"A gait analysis data collection and reduction technique","volume":"10","author":"Davis","year":"1991","journal-title":"Hum. Mov. Sci."},{"key":"ref_36","first-page":"16","article-title":"Consideraciones para el an\u00e1lisis de la marcha humana. T\u00e9cnicas de videogrametr\u00eda, electromiograf\u00eda y dinamometr\u00eda\u2014Considerations for human gait analysis","volume":"2","year":"2008","journal-title":"Rev. Ing. Biom\u00e9d."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Tsiakiri, A., Plakias, S., Giarmatzis, G., Tsakni, G., Christidi, F., Papadopoulou, M., Bakalidou, D., Vadikolias, K., Aggelousis, N., and Vlotinou, P. (2025). Gait Analysis in Multiple Sclerosis: A Scoping Review of Advanced Technologies for Adaptive Rehabilitation and Health Promotion. Biomechanics, 5.","DOI":"10.3390\/biomechanics5030065"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40271-013-0028-x","article-title":"Walking speed and health-related quality of life in multiple sclerosis","volume":"7","author":"Kohn","year":"2014","journal-title":"Patient"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/11591150-000000000-00000","article-title":"Impact of walking impairment in multiple sclerosis: Perspectives of patients and care partners","volume":"4","author":"Larocca","year":"2011","journal-title":"Patient"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. JAMA, 310, 2191.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_41","unstructured":"(2018). Ley Org\u00e1nica 3\/2018, de Protecci\u00f3n de Datos Personales y Garant\u00eda de los Derechos Digitales, Agencia Estatal Bolet\u00edn Oficial del Estado (BOE). Available online: https:\/\/www.boe.es\/buscar\/act.php?id=BOE-A-2018-16673."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1212\/WNL.0000000000001580","article-title":"Longitudinal relationships among posturography and gait measures in multiple sclerosis","volume":"84","author":"Fritz","year":"2015","journal-title":"Neurology"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kalron, A., Nitzani, D., and Achiron, A. (2016). Static posturography across the EDSS scale in people with multiple sclerosis: A cross sectional study. BMC Neurol., 16.","DOI":"10.1186\/s12883-016-0603-6"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/09727531231161994","article-title":"Yoga vs Physical Therapy in Multiple Sclerosis: Results of Randomized Controlled Trial and the Training Protocol","volume":"30","author":"Lysogorskaia","year":"2023","journal-title":"Ann. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Perucca, L., Scarano, S., Russo, G., Robecchi Majnardi, A., and Caronni, A. (2024). Fatigue may improve equally after balance and endurance training in multiple sclerosis: A randomised, crossover clinical trial. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1274809"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ruggieri, S., Bharti, K., Prosperini, L., Giann\u00ec, C., Petsas, N., Tommasin, S., Giglio, L.D., Pozzilli, C., and Pantano, P. (2020). A Comprehensive Approach to Disentangle the Effect of Cerebellar Damage on Physical Disability in Multiple Sclerosis. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00529"},{"key":"ref_48","first-page":"172","article-title":"Use of force platform variables to quantify the effects of chiropractic manipulation on gait symmetry","volume":"10","author":"Robinson","year":"1987","journal-title":"J. Manip. Physiol. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Scataglini, S., Abts, E., Van Bocxlaer, C., Van den Bussche, M., Meletani, S., and Truijen, S. (2024). Accuracy, Validity, and Reliability of Markerless Camera-Based 3D Motion Capture Systems versus Marker-Based 3D Motion Capture Systems in Gait Analysis: A Systematic Review and Meta-Analysis. Sensors, 24.","DOI":"10.3390\/s24113686"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1177\/1352458509348519","article-title":"The Fatigue Scale for Motor and Cognitive Functions (FSMC): Validation of a new instrument to assess multiple sclerosis-related fatigue","volume":"15","author":"Penner","year":"2009","journal-title":"Mult. Scler."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/arclin\/acp038","article-title":"Spanish Multicenter Normative Studies (NEURONORMA Project): Norms for Verbal Span, Visuospatial Span, Letter and Number Sequencing, Trail Making Test, and Symbol Digit Modalities Test","volume":"24","author":"Aguilar","year":"2009","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Mehta, T., Young, H.J., Lai, B., Wang, F., Kim, Y., Thirumalai, M., Tracy, T., Motl, R.W., and Rimmer, J.H. (2019). Comparing the Convergent and Concurrent Validity of the Dynamic Gait Index with the Berg Balance Scale in People with Multiple Sclerosis. Healthcare, 7.","DOI":"10.3390\/healthcare7010027"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.apmr.2016.01.013","article-title":"Reliability and Validity of Ratings of Perceived Exertion in Persons with Multiple Sclerosis","volume":"97","author":"Cleland","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1249\/MSS.0b013e31818cb278","article-title":"Progressive Statistics for Studies in Sports Medicine and Exercise Science","volume":"41","author":"Hopkins","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_55","unstructured":"Kleinbaum, D.G., Kupper, L.L., Nizam, A., and Rosenberg, E.S. (2013). Applied Regression Analysis and Other Multivariable Methods, Cengage Learning."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1109\/TNSRE.2020.2991636","article-title":"Local Dynamic Stability of Gait in People with Early Multiple Sclerosis and No-to-Mild Neurological Impairment","volume":"28","author":"Caronni","year":"2020","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/1352458507082607","article-title":"Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls","volume":"14","author":"Goldman","year":"2008","journal-title":"Mult. Scler."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Du, L., Xi, H., Zhang, S., Zhou, Y., Tao, X., Lv, Y., Hou, X., and Yu, L. (2024). Effects of exercise in people with multiple sclerosis: A systematic review and meta-analysis. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1387658"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cort\u00e9s-P\u00e9rez, I., S\u00e1nchez-Alcal\u00e1, M., Nieto-Esc\u00e1mez, F.A., Castellote-Caballero, Y., Obrero-Gait\u00e1n, E., and Osuna-P\u00e9rez, M.C. (2021). Virtual Reality-Based Therapy Improves Fatigue, Impact, and Quality of Life in Patients with Multiple Sclerosis. A Systematic Review with a Meta-Analysis. Sensors, 21.","DOI":"10.3390\/s21217389"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/1352458507079267","article-title":"Fatigue in multiple sclerosis: Relation to depression, physical impairment, personality and action control","volume":"13","author":"Penner","year":"2007","journal-title":"Mult. Scler."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/25\/22\/6909\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:53:27Z","timestamp":1763121207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/25\/22\/6909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":60,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["s25226909"],"URL":"https:\/\/doi.org\/10.3390\/s25226909","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]}}}