{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:58:57Z","timestamp":1779145137463,"version":"3.51.4"},"reference-count":43,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Gait assessment is key in Parkinson\u2019s disease (PD), but the psychometric properties of common tests like the 6-Minute Walk Test (6MWT) are not fully established. Inertial Measurement Units (IMUs) offer objective gait measures, potentially reducing repeated testing. This study evaluated whether the resampling of the first 2 min of the 6MWT (2\u20196MWT) reflects full-test performance in 43 early-to-mild PD patients (median age 65) at baseline, 1-year, and 2-year follow-ups. A trunk-mounted IMU recorded distance covered, walking duration, stride length, gait speed, cadence, and symmetry. Analysis focused on participants with complete longitudinal data from a multicenter original cohort of 62. Stride length and gait speed (2\u20196MWT vs. 6MWT) demonstrated strong correlations (r &gt; 0.98), near-perfect agreement, &lt;5% error, and stability across follow-ups; cadence showed slightly more variability. The analysis of consecutive 2-min intervals of the 6MWT revealed stable stride length and gait speed, with modest decreases in distance and cadence over time. Exploratory associations of 2\u20196MWT and 6MWT with motor severity and cognitive status were consistent. These results indicate the 2\u20196MWT is a reliable, time-efficient alternative to the full 6MWT for assessing walking capacity in PD, especially in outpatient or fatigue-prone patients. The full 6MWT remains valuable for detecting subtle endurance- or fatigue-related changes.<\/jats:p>","DOI":"10.3390\/s25227076","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:30:59Z","timestamp":1763634659000},"page":"7076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing the Informative Value of 2-Minute Segments of the 6-Minute Walk Test: Insights into a Prospective Study on Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-7866","authenticated-orcid":false,"given":"Rosalia","family":"Zangari","sequence":"first","affiliation":[{"name":"FROM\u2014Research Foundation Bergamo Hospital\u2014ETS, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Brighina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili of Brescia, 25123 Brescia, Italy"},{"name":"Laboratory of Digital Neurology and Biosensors, University of Brescia, 25123 Brescia, Italy"},{"name":"Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, SE-171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7012-707X","authenticated-orcid":false,"given":"Greta","family":"Carioli","sequence":"additional","affiliation":[{"name":"FROM\u2014Research Foundation Bergamo Hospital\u2014ETS, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Oppo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4568-0018","authenticated-orcid":false,"given":"Andrea","family":"Rizzardi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili of Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"},{"name":"Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili of Brescia, 25123 Brescia, Italy"},{"name":"Laboratory of Digital Neurology and Biosensors, University of Brescia, 25123 Brescia, Italy"},{"name":"Brain Health Center, University of Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-6520","authenticated-orcid":false,"given":"Francesco","family":"Biroli","sequence":"additional","affiliation":[{"name":"FROM\u2014Research Foundation Bergamo Hospital\u2014ETS, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Alimonti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/mds.21879","article-title":"The Evolution of Disability in Parkinson Disease","volume":"23","author":"Shulman","year":"2008","journal-title":"Mov. 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