{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:10:39Z","timestamp":1779217839970,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Karen Elise Jensens Foundation"},{"name":"Simon Fougners Hartmanns Family Foundation"},{"name":"Region Nordjylland Innovation Foundation"},{"name":"Skibsreder Per Henriksen"},{"name":"R og hustrus Foundation"},{"name":"The Beckett Foundation"},{"name":"Danish Physiotherapists"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Physical activity often remains low after hospitalisation for acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). Although post-hospitalisation rehabilitation has shown to support recovery, its impact on daily activity levels in the early post-exacerbation phase is unclear. This study describes the changes in physical activity (PA) and clinical outcomes during an 8-week rehabilitation following hospitalisation for AECOPD. This prospective observational cohort study included patients recently discharged after AECOPD from Aalborg University Hospital, Denmark. Participants received municipality-delivered post-hospitalisation rehabilitation consisting of tailored physiotherapy and occupational therapy of individually determined frequency. PA was assessed using thigh-worn triaxial accelerometers measuring 24 h\/day over 8 weeks. Clinical outcomes included lung function (FEV1% predicted), dyspnoea scores, health-related quality of life (EuroQol 5-dimension, 5-level (EQ-5D-5L); EuroQol visual analogue scale (EQ-VAS)), frailty (Clinical Frailty Scale (CFS)), functional status (Short Physical Performance Battery (SPPB)), and symptom burden (COPD Assessment Test (CAT); St. George\u2019s Respiratory Questionnaire (SGRQ)). Changes from baseline to 8 weeks were analysed using linear mixed-effects models and bootstrap resampling. Forty-three participants with a mean age 73.4 years, 67.4% female, and moderate frailty (CFS 5.4 \u00b1 1.3) were included. Physical activity remained largely unchanged. Gait speed and total SPPB declined, whereas self-perceived health improved (EQ-VAS \u0394 +7.8, p = 0.008). Lung function, dyspnoea, and health related quality of life scores showed no significant change. In this frail, recently admitted COPD population, physical activity did not increase during the rehabilitation period, and some functional parameters declined. The improvement in self-perceived health suggests a divergence between subjective and objective outcomes. These findings highlight the need for long-term, tailored, and flexible approaches to support recovery after AECOPD.<\/jats:p>","DOI":"10.3390\/s26020384","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:46:43Z","timestamp":1767786403000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Changes in Physical Activity and Clinical Outcomes During Post-Hospitalisation Rehabilitation for Persons with COPD: A Prospective Observational Cohort Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6039-1223","authenticated-orcid":false,"given":"Anna L.","family":"Stoustrup","sequence":"first","affiliation":[{"name":"Respiratory Research Aalborg, Department of Respiratory Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-4671","authenticated-orcid":false,"given":"Phillip K.","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, 9000 Aalborg, Denmark"},{"name":"Department of Anaesthesiology and Intensive Care, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-5833","authenticated-orcid":false,"given":"Lars P.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Respiratory and Critical Care Group, Department of Health Science and Technology, The Faculty of Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4418-0133","authenticated-orcid":false,"given":"Thorvaldur S.","family":"Palsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, 9000 Aalborg, Denmark"},{"name":"Department of Physiotherapy and Occupational Therapy, The Faculty of Medicine, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6763-1653","authenticated-orcid":false,"given":"Kristina K.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Respiratory Research Aalborg, Department of Respiratory Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-1553","authenticated-orcid":false,"given":"Jane","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Public Health and Epidemiology, Department of Health Science and Technology, The Faculty of Medicine, Aalborg University, 9000 Aalborg, Denmark"},{"name":"Aalborg Health and Rehabilitation Center, Aalborg Municipality, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-3654","authenticated-orcid":false,"given":"Ulla M.","family":"Weinreich","sequence":"additional","affiliation":[{"name":"Respiratory Research Aalborg, Department of Respiratory Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark"},{"name":"Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1183\/09031936.00023214","article-title":"Changes in physical activity and all-cause mortality in COPD","volume":"44","author":"Vaes","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000296504","article-title":"Physical activity, health status and risk of hospitalization in patients with severe chronic obstructive pulmonary disease","volume":"80","author":"Benzo","year":"2010","journal-title":"Respiration"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"105988","DOI":"10.1016\/j.rmed.2020.105988","article-title":"Risk factors and associated outcomes of hospital readmission in COPD: A systematic review","volume":"173","author":"Njoku","year":"2020","journal-title":"Respir. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00008483-200309000-00006","article-title":"Walking activity measured by accelerometry during respiratory rehabilitation","volume":"23","author":"Coronado","year":"2003","journal-title":"J. Cardiopulm. Rehabil."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.7600\/jpfsm.4.279","article-title":"Skeletal muscle dysfunction and oxidative stress in patients with chronic obstructive lung disease","volume":"4","author":"Nemoto","year":"2015","journal-title":"J. Phys. Fit. Sport. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1165\/rcmb.2019-0319ED","article-title":"Development of limb muscle dysfunction in chronic obstructive pulmonary disease: Smoking, inflammation, or simply disuse?","volume":"62","author":"Iepsen","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"00217-2022","DOI":"10.1183\/23120541.00217-2022","article-title":"All-cause admissions following a first ever exacerbation-related hospitalisation in COPD","volume":"9","author":"Jacobsen","year":"2023","journal-title":"ERJ Open Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2147\/COPD.S58136","article-title":"Depression and anxiety predict health-related quality of life in chronic obstructive pulmonary disease: Systematic review and meta-analysis","volume":"9","author":"Blakemore","year":"2014","journal-title":"Int. J. Chron. Obstruct Pulmon Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41533-018-0085-7","article-title":"Facilitators and barriers to physical activity following pulmonary rehabilitation in COPD: A systematic review of qualitative studies","volume":"28","author":"Robinson","year":"2018","journal-title":"npj Prim. Care Respir. Med."},{"key":"ref_10","first-page":"145282","article-title":"Activities of Daily Living in Patients with Chronic Obstructive Pulmonary Disease: A Hybrid Concept Analysis","volume":"12","author":"Monjazebi","year":"2023","journal-title":"Med.-Surg. Nurs. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/COPD.S54457","article-title":"Barriers to and enablers of physical activity in patients with COPD following a hospital admission: A qualitative study","volume":"9","author":"Thorpe","year":"2014","journal-title":"Int. J. COPD"},{"key":"ref_12","first-page":"CD003793","article-title":"Pulmonary rehabilitation for chronic obstructive pulmonary disease","volume":"2015","author":"McCarthy","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","first-page":"CD005305","article-title":"Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease","volume":"12","author":"Puhan","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"s2","DOI":"10.1136\/thorax-2023-220439","article-title":"British Thoracic Society Clinical Statement on pulmonary rehabilitation","volume":"78","author":"Man","year":"2023","journal-title":"Thorax"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"00173-2019","DOI":"10.1183\/23120541.00173-2019","article-title":"Early pulmonary rehabilitation after acute exacerbation of COPD: A randomised controlled trial","volume":"6","author":"Juhl","year":"2020","journal-title":"ERJ Open Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/15412555.2019.1598965","article-title":"Recovery Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease\u2014A Review","volume":"16","author":"Wageck","year":"2019","journal-title":"COPD"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6596278","DOI":"10.1155\/2018\/6596278","article-title":"Reliability and Construct Validity of the SENS Motion\u00ae Activity Measurement System as a Tool to Detect Sedentary Behaviour in Patients with Knee Osteoarthritis","volume":"2018","author":"Bartholdy","year":"2018","journal-title":"Arthritis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"170125","DOI":"10.1183\/16000617.0125-2017","article-title":"Personalised pulmonary rehabilitation in COPD","volume":"27","author":"Wouters","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e002573","DOI":"10.1136\/bmjresp-2024-002573","article-title":"Cluster randomised controlled trial on the effects of long-term home-based exercise for patients with chronic obstructive pulmonary disease with recent exacerbation: Research protocol of the COPDtoParis Project","volume":"12","author":"Stoustrup","year":"2025","journal-title":"BMJ Open Respir Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J. Anaesth."},{"key":"ref_21","unstructured":"(2025, June 03). Health Act (Consolidation Act No. 1015 of 5 September 2024), \u00a7 140. Ministry of the Interior and Health; Retsinformation. Available online: https:\/\/www.retsinformation.dk\/eli\/lta\/2024\/1015."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12966-024-01627-1","article-title":"Thigh-worn accelerometry: A comparative study of two no-code classification methods for identifying physical activity types","volume":"21","author":"Lendt","year":"2024","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3934\/publichealth.2016.2.298","article-title":"Validation and Comparison of Accelerometers Worn on the Hip, Thigh, and Wrists for Measuring Physical Activity and Sedentary Behavior","volume":"3","author":"Montoye","year":"2016","journal-title":"AIMS Public Health"},{"key":"ref_24","first-page":"9230081","article-title":"Validation of Two Activity Monitors in Slow and Fast Walking Hospitalized Patients","volume":"2022","author":"Pedersen","year":"2022","journal-title":"Rehabil. Res. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1183\/23120541.00084-2017","article-title":"mMRC dyspnoea scale indicates impaired quality of life and increased pain in patients with idiopathic pulmonary fibrosis","volume":"3","author":"Rajala","year":"2017","journal-title":"ERJ Open Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1503\/cmaj.050051","article-title":"A global clinical measure of fitness and frailty in elderly people","volume":"173","author":"Rockwood","year":"2005","journal-title":"C Can. Med. Assoc. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/thoraxjnl-2015-207782","article-title":"The EQ-5D-5L health status questionnaire in COPD: Validity, responsiveness and minimum important difference","volume":"71","author":"Nolan","year":"2016","journal-title":"Thorax"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1183\/09031936.00025214","article-title":"The COPD assessment test: A systematic review","volume":"44","author":"Gupta","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/ageing\/afaa138","article-title":"Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease","volume":"50","author":"Fermont","year":"2021","journal-title":"Age Ageing"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1164\/ajrccm\/145.6.1321","article-title":"A self-complete measure of health status for chronic airflow limitation. The St. George\u2019s Respiratory Questionnaire","volume":"145","author":"Jones","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.rmed.2012.08.016","article-title":"Short term and long term effects of pulmonary rehabilitation on physical activity in COPD","volume":"106","author":"Egan","year":"2012","journal-title":"Respir. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1183\/13993003.01391-2014","article-title":"Risk of death and readmission of hospital-admitted COPD exacerbations: European COPD Audit","volume":"47","author":"Hartl","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lee, K., and Lee, G. (2021). Pulmonary Function, Physical Activity and Quality of Life in Chronic Obstructive Pulmonary Disease Patients: Secondary Data Analysis, Data from the Korea National Health and Nutrition Examination Survey 2015\u20132018. Res. Sq.","DOI":"10.21203\/rs.3.rs-1069651\/v1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1164\/rccm.201603-0602OC","article-title":"Benefits of long-term pulmonary rehabilitation maintenance program in patients with severe chronic obstructive pulmonary disease","volume":"195","author":"Cejudo","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1378\/chest.13-2017","article-title":"Determinants of gait speed in COPD","volume":"146","author":"Karpman","year":"2014","journal-title":"Chest"},{"key":"ref_36","first-page":"00838","article-title":"Global mortality and readmission rates following COPD exacerbation-related hospitalisation: A meta-analysis of 65,945 individual patients","volume":"10","author":"Crutsen","year":"2024","journal-title":"ERJ Open Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0140-6736(14)60115-X","article-title":"Stratified medicines: Towards better treatment for disease","volume":"383","author":"Bell","year":"2014","journal-title":"Lancet"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kubincov\u00e1, A., Tak\u00e1\u010d, P., Demjanovi\u010d Kendrov\u00e1, L., and Joppa, P. (2023). Predictors of Quality-of-Life Improvement at Different Minimum Clinically Important Difference Values in Patients with Chronic Obstructive Pulmonary Disease after Climatic Rehabilitation Treatment. Life, 13.","DOI":"10.3390\/life13081763"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"14830","DOI":"10.1038\/s41598-025-99555-y","article-title":"Path analysis of predictors of frailty in hospitalised patients with chronic obstructive pulmonary disease","volume":"15","author":"Jiang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_40","first-page":"15","article-title":"Home-based Pulmonary Rehabilitation is Effective in Frail COPD Patients with Chronic Respiratory Failure","volume":"9","author":"Gephine","year":"2022","journal-title":"Chronic Obstr. Pulm. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/MLR.0000000000000940","article-title":"Time-varying Readmission Diagnoses During 30 Days After Hospitalization for COPD Exacerbation","volume":"56","author":"Goto","year":"2018","journal-title":"Med. Care"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1602129","DOI":"10.1183\/13993003.02129-2016","article-title":"Home-based maintenance tele-rehabilitation reduces the risk for acute exacerbations of COPD, hospitalisations and emergency department visits","volume":"49","author":"Vasilopoulou","year":"2017","journal-title":"Eur Respir. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.rmed.2013.04.014","article-title":"A novel approach to long-term respiratory care: Results of a community-based post-rehabilitation maintenance program in COPD","volume":"107","author":"Beauchamp","year":"2013","journal-title":"Respir. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1183\/09031936.00078707","article-title":"COPD patients\u2019 ability to follow exercise influences short-term outcomes of rehabilitation","volume":"31","author":"Puhan","year":"2008","journal-title":"Eur. Respir. J."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Al-Sharifi, F., Winther Frederiksen, H., Knold Rossau, H., Norredam, M., and Zwisler, A.D. (2019). Access to cardiac rehabilitation and the role of language barriers in the provision of cardiac rehabilitation to migrants. BMC Health Serv. Res., 19.","DOI":"10.1186\/s12913-019-4041-1"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/1474515120946313","article-title":"Are survivors of cardiac arrest provided with standard cardiac rehabilitation?\u2014Results from a national survey of hospitals and municipalities in Denmark","volume":"20","author":"Tang","year":"2021","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1513\/AnnalsATS.201607-547OC","article-title":"Patients with Chronic Obstructive Pulmonary Disease Walk with Altered Step Time and Step Width Variability as Compared with Healthy Control Subjects","volume":"14","author":"Yentes","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1183\/09031936.06.00064105","article-title":"Quantifying physical activity in daily life with questionnaires and motion sensors in COPD","volume":"27","author":"Pitta","year":"2006","journal-title":"Eur. Respir. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.rmed.2012.11.016","article-title":"Barriers to pulmonary rehabilitation: Characteristics that predict patient attendance and adherence","volume":"107","author":"Hayton","year":"2013","journal-title":"Respir. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1001\/jama.2020.4437","article-title":"Association Between Initiation of Pulmonary Rehabilitation After Hospitalization for COPD and 1-Year Survival Among Medicare Beneficiaries","volume":"323","author":"Lindenauer","year":"2020","journal-title":"JAMA"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/26\/2\/384\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:48:30Z","timestamp":1767786510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/26\/2\/384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["s26020384"],"URL":"https:\/\/doi.org\/10.3390\/s26020384","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]}}}