{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:06:11Z","timestamp":1779271571005,"version":"3.51.4"},"reference-count":83,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Wearable sensors enable continuous recording of electrocardiographic, photoplethysmographic, and inertial signals and have accelerated the development of digital biomarkers in cardiovascular medicine. Transthyretin amyloidosis (ATTR) is a progressive multisystem disease characterized by arrhythmia, conduction disturbances, hemodynamic impairment, autonomic dysfunction, and gait abnormalities, making it theoretically suitable for multimodal wearable monitoring. This review summarizes current knowledge on wearable applications in amyloidosis with ATTR serving as an illustrative case, evaluates the plausibility of extrapolating signal-based biomarkers from related cardiovascular and neurological cohorts, and outlines methodological and implementation challenges. ATTR-specific data remain limited to small observational studies, mainly on long-term rhythm monitoring and supervised functional assessment. More comprehensive findings support the extraction of metrics such as atrial fibrillation burden, activity patterns, gait variability, and heart rate variability. However, ATTR-related structural remodeling and high arrhythmia burden may distort conventional digital biomarkers, necessitating disease-specific preprocessing and prospective validation. Wearable monitoring in ATTR is technically feasible and biologically plausible but remains investigational. Before routine integration into care pathways can be recommended, standardized, phenotype-stratified studies are needed that link wearable-derived characteristics to assessed clinical outcomes.<\/jats:p>","DOI":"10.3390\/s26103035","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:39:32Z","timestamp":1778513972000},"page":"3035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wearables for Telemonitoring in ATTR-Amyloidosis: Current Perspectives"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8847-5574","authenticated-orcid":false,"given":"Andreas","family":"Kind","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiology, Angiology and Intensive CareMedicine, Charit\u00e9 Virchow Klinikum, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8711-5526","authenticated-orcid":false,"given":"Helena","family":"Pernice","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9 University Medicine Berlin, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-2159","authenticated-orcid":false,"given":"Gina","family":"Barzen","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiology, Angiology and Intensive Care Medicine, Charit\u00e9 Campus Mitte, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-9041","authenticated-orcid":false,"given":"Jan","family":"Gr\u00f6schel","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiology, Angiology and Intensive Care Medicine, Charit\u00e9 Campus Mitte, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelian","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9 University Medicine Berlin, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Werhahn","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiology, Angiology and Intensive CareMedicine, Charit\u00e9 Virchow Klinikum, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and 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Research), Partner Site Berlin, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-0773","authenticated-orcid":false,"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Deutsches Herzzentrum der Charit\u00e9 (DHZC), Department of Cardiology, Angiology and Intensive Care Medicine, Charit\u00e9 Campus Mitte, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-0072","authenticated-orcid":false,"given":"Katrin","family":"Hahn","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Department of Neurology, Charit\u00e9 University Medicine Berlin, 10117 Berlin, Germany"},{"name":"Berlin Institute of Health at Charit\u00e9, Charit\u00e9 University Medicine Berlin, 10178 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0987-8007","authenticated-orcid":false,"given":"Sebastian","family":"Spethmann","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"},{"name":"Amyloidosis Center Charit\u00e9 Berlin (ACCB), Amyloidosis Center of Charit\u00e9, Campus Charit\u00e9 Mitte, Campus Benjamin Franklin and Campus Virchow Klinikum, 10117 Berlin, 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