{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:58:26Z","timestamp":1785473906383,"version":"3.56.0"},"reference-count":51,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PubArt program of the National University of Science and Technology POLITEHNICA Bucharest"},{"name":"STEP project \u201cBioinnovative Center for Integrated Medical Data and Research in Bucharest\u201d","award":["350221\/2026"],"award-info":[{"award-number":["350221\/2026"]}]},{"name":"project \u201cSupport for the Development and Strengthening of DANUBIUS-RO\u201d","award":["1.D\/2025"],"award-info":[{"award-number":["1.D\/2025"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Oncology care increasingly depends on heterogeneous sensing streams generated by computed tomography (CT), radiotherapy planning systems, wearable devices, home respiratory sensors, patient-reported outcomes, and clinical records. These data streams are often processed separately, limiting their value for longitudinal, context-aware review. This study proposes OncoSense-Agent, a reliability-aware agentic multimodal sensing architecture for CT-guided respiratory monitoring in oncology care. The architecture links CT-derived anatomical evidence with wearable physiology, respiratory symptoms, functional assessment, treatment context, and explainable human-in-the-loop review-priority generation. To move beyond a purely conceptual design, we implemented a lung-focused proof-of-concept with six bounded software agents: Imaging Reliability, Wearable Monitoring, Respiratory Review, Treatment Context, Multimodal Fusion, and Explainability. The prototype used real nnU-Net v2 3D lung segmentation metrics from 139 patients with complete bilateral lung CT data as the imaging anchor, while wearable, respiratory, symptom, and treatment-context channels were introduced as deterministic overlays for controlled validation. OncoSense-Agent changed review-priority assignment relative to CT-only assessment in 78\/139 cases (56.1%), assigned 111\/139 cases (79.9%) to high-priority or high-uncertainty tiers, and showed increasing Safety Gate activation as CT quality declined. Three illustrative cases demonstrate hidden respiratory deterioration, wearable data-quality uncertainty, and treatment-context risk not captured by CT-only assessment. The prototype does not establish clinical diagnostic accuracy, but demonstrates operational, auditable, reliability-aware multimodal review-priority generation for clinician-supervised oncology monitoring.<\/jats:p>","DOI":"10.3390\/s26154817","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:53:31Z","timestamp":1785333211000},"page":"4817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Agentic Multimodal Sensing Architecture for CT-Guided Wearable and Respiratory Monitoring in Oncology Care"],"prefix":"10.3390","volume":"26","author":[{"given":"Denisa-Daniela","family":"Frimu-Pascu","sequence":"first","affiliation":[{"name":"Faculty of Automatic Control and Computer Science, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7534-4367","authenticated-orcid":false,"given":"Ciprian","family":"Dobre","sequence":"additional","affiliation":[{"name":"Faculty of Automatic Control and Computer Science, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania"},{"name":"Romanian Academy of Sciences, 030167 Bucharest, Romania"},{"name":"National Institute for Research and Development in Informatics, 011455 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3338-8107","authenticated-orcid":false,"given":"Mihai","family":"Olteanu","sequence":"additional","affiliation":[{"name":"Discipline of Internal Medicine-Pneumology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.ijrobp.2017.12.013","article-title":"American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology","volume":"100","author":"Mayo","year":"2018","journal-title":"Int. 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