{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:06:32Z","timestamp":1790075192239,"version":"4.0.1"},"reference-count":33,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Progressive neurodegenerative diseases are often associated with motor symptoms, among which tremor is one of the most debilitating manifestations, significantly compromising daily activities and quality of life. Continuous, non-invasive monitoring of tremor characteristics helps to assess disease progression and optimize treatment strategies. For this reason, wearable measurement systems can provide an objective and non-invasive means for the quantitative characterization and monitoring of tremor-related movements. This study addresses the development of a compact, low-power wearable board for real-time tremor monitoring based on the Nicla Sense ME embedded system. The proposed device performs on-board processing to extract spectral features of movement and wirelessly sends them via Bluetooth Low Energy to a remote host, enabling on-demand visualization or storage of tremor data. The measurement system was technically validated through a comparative experimental protocol based on the simultaneous acquisition of tremor signals using the proposed device and a commercial Shimmer3 IMU as the reference system. The comparison considered both the similarity of the measured spectrograms and the agreement in dominant-frequency estimation. Spectrogram correlation coefficients reached 0.85, with amplitude MAE and RMSE values as low as 0.07 m\/s2 and 0.14 m\/s2, respectively. For dominant-frequency estimation, Pearson correlation coefficients reached 0.99, with MAE and RMSE values as low as 0.17 Hz and 0.20 Hz. These results support the feasibility of the proposed architecture as a practical wearable solution for quantitative hand tremor monitoring.<\/jats:p>","DOI":"10.3390\/s26185949","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:21:48Z","timestamp":1790072508000},"page":"5949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Stand-Alone Wearable Measurement System for Continuous Hand Tremor Monitoring"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8341-1830","authenticated-orcid":false,"given":"Laura","family":"Arruzzoli","sequence":"first","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0629-6867","authenticated-orcid":false,"given":"Carmen","family":"Galletta","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Messina, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-2232","authenticated-orcid":false,"given":"Giovanni","family":"Gugliandolo","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Messina, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6801-6875","authenticated-orcid":false,"given":"Mariangela","family":"Latino","sequence":"additional","affiliation":[{"name":"Institute for Chemical-Physical Processes, National Research Council of Italy (IPCF-CNR), Viale Ferdinando Stagno d\u2019Alcontres, 98158 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-6812","authenticated-orcid":false,"given":"Giovanni","family":"Crupi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-7454","authenticated-orcid":false,"given":"Cristiano","family":"De Marchis","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Messina, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-2182","authenticated-orcid":false,"given":"Nicola","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Engineering, University of Messina, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1097\/MS9.0000000000001142","article-title":"Parkinson\u2019s disease updates: Addressing the pathophysiology, risk factors, genetics, diagnosis, along with the medical and surgical treatment","volume":"85","author":"Prajjwal","year":"2023","journal-title":"Ann. 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