{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:13:13Z","timestamp":1790799193971,"version":"4.1.0"},"reference-count":54,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["EST-0102-000260200\/15"],"award-info":[{"award-number":["EST-0102-000260200\/15"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Pharm."],"abstract":"<jats:p>Depression is a common disease affecting more than 300 million people worldwide. Since Lippia sidoides has shown central nervous system effects in previous works, we aimed to investigate the effect of L. sidoides essential oil and its major compound, thymol on a corticosterone-induced depression model in mice. Male mice (20\u201325 g) received corticosterone (20 mg\/kg, subcutaneously), once a day for 22 days. From the 16th day on, mice were grouped to receive either corticosterone or L. sidoides essential oil (100 and 200 mg\/kg), or thymol (25 and 50 mg\/kg) or fluoxetine (35 mg\/kg) by gavage. The forced swimming test, tail suspension, open field, elevated plus maze and sucrose preference tests were performed from the 19th to 22nd day. Data were analyzed by ANOVA followed by the Student-Newman-Keuls as a post hoc test and the results were considered significant when p &lt; 0.05. It was shown that L. sidoides essential oil, thymol and fluoxetine decreased the immobility time in the tail suspension and forced swimming tests and none of these altered locomotor activity in the open field test. However, the drugs increased the amount of grooming. In the elevated plus maze, all drugs increased the number of entries and the time of permanence in the open arms. In the sucrose preference test, the L. sidoides essential oil, thymol and fluoxetine reversed anhedonia. These results suggest that the thymol and L. sidoides essential oil have an antidepressant-like effect, similar to fluoxetine. However, future studies should be encouraged to enhance understanding of the effects of essential oil and thymol for the treatment of depression.<\/jats:p>","DOI":"10.3390\/scipharm86030027","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T11:02:05Z","timestamp":1530097325000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antidepressant-Like Effect of Lippia sidoides CHAM (Verbenaceae) Essential Oil and Its Major Compound Thymol in Mice"],"prefix":"10.3390","volume":"86","author":[{"given":"Michele Sanford Rangel","family":"Parente","sequence":"first","affiliation":[{"name":"Department of Biotechnology, INTA University Center, UNINTA, Sobral, CE 62050-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliphy Rodrigues","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience, Faculty of Medicine, Federal University of Cear\u00e1, UFC, 100 Comandante Mauroc\u00e9lio Rocha Pontes Avenue, Derby, Sobral, CE 62042-280, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Ara\u00fajo","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience, Faculty of Medicine, Federal University of Cear\u00e1, UFC, 100 Comandante Mauroc\u00e9lio Rocha Pontes Avenue, Derby, Sobral, CE 62042-280, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Jordana Ara\u00fajo","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, INTA University Center, UNINTA, Sobral, CE 62050-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Sousa de","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, INTA University Center, UNINTA, Sobral, CE 62050-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Linhares","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, INTA University Center, UNINTA, Sobral, CE 62050-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaelly Maria Pinheiro","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, INTA University Center, UNINTA, Sobral, CE 62050-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristides \u00c1vilo do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, INTA University Center, UNINTA, Sobral, CE 62050-130, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8089-730X","authenticated-orcid":false,"given":"Francisco Eduardo Arag\u00e3o","family":"Catunda J\u00fanior","sequence":"additional","affiliation":[{"name":"Center for Exact, Natural and Technological Sciences, State University of the Tocantina Region of Maranh\u00e3o, UEMASUL, Imperatriz, MA 65901-480, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6753-5710","authenticated-orcid":false,"given":"Carla Thiciane Vasconcelos de","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience, Faculty of Medicine, Federal University of Cear\u00e1, UFC, 100 Comandante Mauroc\u00e9lio Rocha Pontes Avenue, Derby, Sobral, CE 62042-280, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2017, May 17). 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