{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:57:02Z","timestamp":1775869022986,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660696"],"award-info":[{"award-number":["81660696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019D01C217"],"award-info":[{"award-number":["2019D01C217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["XJDX1713"],"award-info":[{"award-number":["XJDX1713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","award":["81660696"],"award-info":[{"award-number":["81660696"]}]},{"name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","award":["2019D01C217"],"award-info":[{"award-number":["2019D01C217"]}]},{"name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","award":["XJDX1713"],"award-info":[{"award-number":["XJDX1713"]}]},{"name":"\u201cFourteenth Five-Year Plan\u201d Key Discipline Construction Project of Xinjiang Autonomous Region (2021)","award":["81660696"],"award-info":[{"award-number":["81660696"]}]},{"name":"\u201cFourteenth Five-Year Plan\u201d Key Discipline Construction Project of Xinjiang Autonomous Region (2021)","award":["2019D01C217"],"award-info":[{"award-number":["2019D01C217"]}]},{"name":"\u201cFourteenth Five-Year Plan\u201d Key Discipline Construction Project of Xinjiang Autonomous Region (2021)","award":["XJDX1713"],"award-info":[{"award-number":["XJDX1713"]}]},{"name":"key Laboratory of Xinjiang Autonomous Region","award":["81660696"],"award-info":[{"award-number":["81660696"]}]},{"name":"key Laboratory of Xinjiang Autonomous Region","award":["2019D01C217"],"award-info":[{"award-number":["2019D01C217"]}]},{"name":"key Laboratory of Xinjiang Autonomous Region","award":["XJDX1713"],"award-info":[{"award-number":["XJDX1713"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Separations"],"abstract":"<jats:p>Cydonia oblonga miller (quince) plant serves as a potential folk medicine for treating hypertension and cardiovascular diseases in China. However, to the best of our knowledge, no study has been conducted on the polyphenolic profile and anti-adipogenic effect of quince fruit grown in China. In the current study, we aimed to investigate the quince fruit extract\u2019s major phenolic compounds, evaluate their antioxidant activity, and examine their effect on adipogenesis in 3T3-L1 cells. A rapid and sensitive analytical method was established for the simultaneous determination of major polyphenolic compounds by using ultra-pressure liquid chromatography coupled with a triple quadrupole mass spectrometer (UPLC-MS\/MS). Among the 10 compounds, the cryptochlorgenic acid was noticed as the most abundant compound of both purified (242.44 \u00b1 0.73 \u00b5g\/mg dw) and unpurified extract (3.37 \u00b1 0.01 \u00b5g\/mg dw) followed by quercetin 3-rutinoside and chlorogenic acid. Alternatively, both extracts possessed a high quantity of phenolic acids (purified extract = 483.10 \u00b1 5.16 \u00b5g\/mg dw and unpurified extract = 7.89 \u00b1 0.02 \u00b5g\/mg dw). The purified extract exhibited a strong antioxidant capacity (DPPH: EC50 = 3.316 \u00b5g\/mL, ABTS: EC50 = 36.38 \u00b5g\/mL) as compared to the unpurified extract. Additionally, our results also showed that the extract at 100 \u00b5g\/mL significantly suppressed the preadipocyte differentiation and decreased the lipid droplets up to 69% in mature adipocytes. The present study highlights an accurate and fast detection method for quince fruit extract polyphenolic compounds with its antioxidant and antiadipogenic effects. The study also provides the necessary information for the rational development and utilization of quince fruit extract as a source of phytochemicals.<\/jats:p>","DOI":"10.3390\/separations9070167","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T01:40:36Z","timestamp":1656639636000},"page":"167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Major Polyphenolic Compounds of Cydonia oblonga Miller (Quince) Fruit Extract by UPLC-MS\/MS and Its Effect on Adipogenesis in 3T3-L1 Cells"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2514-6877","authenticated-orcid":false,"given":"Nawaz","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nulibiya","family":"Maihemuti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhadaisi","family":"Nuer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayisaier","family":"Abudurousuli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimilihan","family":"Simayi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziruo","family":"Talihati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sendaer","family":"Hailati","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainiwaer","family":"Wumaier","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi 830011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pi\u0105tczak, E., Dybowska, M., P\u0142uciennik, E., Ko\u015bla, K., Kolniak-Ostek, J., and Kalinowska-Lis, U. 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