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The diagnosis of the most common subtype of the disease, the large duct PSC, is based on the presence of elevation of cholestatic indices, the association of typical cholangiographic findings assessed by magnetic resonance cholangiography and the exclusion of causes of secondary sclerosing cholangitis. Liver biopsy is not routinely applied for the diagnosis of large duct PSC but is mandatory in the case of suspicion of small duct PSC or overlap with autoimmune hepatitis.<\/jats:p>","DOI":"10.3390\/tomography10010005","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:38:51Z","timestamp":1704775131000},"page":"47-65","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Primary Sclerosing Cholangitis: Diagnostic Criteria"],"prefix":"10.3390","volume":"10","author":[{"given":"Nora","family":"Cazzagon","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy"},{"name":"Gastroenterology Unit, Azienda Ospedale\u2014Universit\u00e0 Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Sarcognato","sequence":"additional","affiliation":[{"name":"Department of Pathology, Azienda ULSS2 Marca Trevigiana, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7622-6051","authenticated-orcid":false,"given":"Elisa","family":"Catanzaro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy"},{"name":"Gastroenterology Unit, Azienda Ospedale\u2014Universit\u00e0 Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Bonaiuto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Peviani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy"},{"name":"Gastroenterology Unit, Azienda Ospedale\u2014Universit\u00e0 Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pezzato","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy"},{"name":"Gastroenterology Unit, Azienda Ospedale\u2014Universit\u00e0 Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-9826","authenticated-orcid":false,"given":"Raffaella","family":"Motta","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health\u2014DCTV, University of Padova, 35128 Padova, Italy"},{"name":"Radiology Unit, Azienda Ospedale\u2014Universit\u00e0 Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jhep.2017.07.022","article-title":"Primary sclerosing cholangitis\u2014A comprehensive review","volume":"67","author":"Karlsen","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3109\/00365528709011139","article-title":"Primary sclerosing cholangitis: A long-term follow-up study","volume":"22","author":"Aadland","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1053\/j.gastro.2017.02.038","article-title":"Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate with Course of Primary Sclerosing Cholangitis","volume":"152","author":"Trivedi","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/hep.26565","article-title":"Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis","volume":"58","author":"Boonstra","year":"2013","journal-title":"Hepatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaut.2018.10.008","article-title":"Autoimmune sclerosing cholangitis: Evidence and open questions","volume":"95","author":"Vergani","year":"2018","journal-title":"J. Autoimmun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jhep.2022.05.011","article-title":"EASL Clinical Practice Guidelines on sclerosing cholangitis","volume":"77","author":"Chazouilleres","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hep.32771","article-title":"AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma","volume":"77","author":"Bowlus","year":"2022","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/hep.20287","article-title":"Cost-minimization analysis of MRC versus ERCP for the diagnosis of primary sclerosing cholangitis","volume":"40","author":"Talwalkar","year":"2004","journal-title":"Hepatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1148\/radiol.10091953","article-title":"Primary sclerosing cholangitis: Meta-analysis of diagnostic performance of MR cholangiopancreatography","volume":"256","author":"Dave","year":"2010","journal-title":"Radiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1055\/s-0043-107029","article-title":"Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline","volume":"49","author":"Aabakken","year":"2017","journal-title":"Endoscopy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/gutjnl-2018-317993","article-title":"British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis","volume":"68","author":"Chapman","year":"2019","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1572-0241.2004.04106.x","article-title":"Dominant strictures in patients with primary sclerosing cholangitis","volume":"99","author":"Asztely","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1053\/j.gastro.2016.06.021","article-title":"Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease","volume":"151","author":"Lunder","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_14","first-page":"551","article-title":"Chronic active hepatitis with cholestatic features. II. A histopathological study","volume":"72","author":"Shouval","year":"1979","journal-title":"Am. J. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: Review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/gut.21.10.870","article-title":"Primary sclerosing cholangitis: A review of its clinical features, cholangiography, and hepatic histology","volume":"21","author":"Chapman","year":"1980","journal-title":"Gut"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0168-8278(00)80061-6","article-title":"Serum autoantibodies in patients with primary sclerosing cholangitis","volume":"32","author":"Angulo","year":"2000","journal-title":"J. Hepatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.3748\/wjg.14.3781","article-title":"Autoantibodies in primary sclerosing cholangitis","volume":"14","author":"Hov","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"102787","DOI":"10.1016\/j.autrev.2021.102787","article-title":"Anti-neutrophil cytoplasm antibodies (ANCA) in autoimmune diseases: A matter of laboratory technique and clinical setting","volume":"20","author":"Granito","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jhep.2010.09.002","article-title":"Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue","volume":"54","author":"Boberg","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/hep.29293","article-title":"Recommendations on the use of magnetic resonance imaging in PSC-A position statement from the International PSC Study Group","volume":"66","author":"Schramm","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.clinre.2015.07.005","article-title":"Magnetic resonance cholangiography: Current and future perspectives","volume":"39","author":"Hodoul","year":"2015","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1148\/rg.296095515","article-title":"Hepatobiliary-specific MR contrast agents: Role in imaging the liver and biliary tree","volume":"29","author":"Seale","year":"2009","journal-title":"RadioGraphics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jmri.23683","article-title":"Gadoxetic acid-enhanced T1-weighted MR cholangiography in primary sclerosing cholangitis","volume":"36","author":"Frydrychowicz","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.crad.2013.12.008","article-title":"Diagnostic workup of primary sclerosing cholangitis: The benefit of adding gadoxetic acid-enhanced T1-weighted magnetic resonance cholangiography to conventional T2-weighted magnetic resonance cholangiography","volume":"69","author":"Nolz","year":"2014","journal-title":"Clin. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2214\/ajr.179.2.1790399","article-title":"MR Cholangiopancreatography in Patients with Primary Sclerosing Cholangitis: Interobserver Variability and Comparison with Endoscopic Retrograde Cholangiopancreatography","volume":"179","author":"Vitellas","year":"2002","journal-title":"Am. J. Roentgenol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.acra.2011.08.007","article-title":"Contrast Enhanced Liver MRI in Patients with Primary Sclerosing Cholangitis","volume":"18","author":"Husarik","year":"2011","journal-title":"Acad. Radiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"677.e1","DOI":"10.1016\/j.crad.2018.02.010","article-title":"Gadolinium-based relative contrast enhancement in primary sclerosing cholangitis: Additional benefit for clinicians?","volume":"73","author":"Keller","year":"2018","journal-title":"Clin. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s00330-018-5614-9","article-title":"Prospective comparison of diffusion-weighted MRI and dynamic Gd-EOB-DTPA-enhanced MRI for detection and staging of hepatic fibrosis in primary sclerosing cholangitis","volume":"29","author":"Keller","year":"2018","journal-title":"Eur. Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejro.2014.12.004","article-title":"Visual assessment of biliary excretion of Gd-EOB-DTPA in patients with suspected diffuse liver disease\u2014A biopsy-verified prospective study","volume":"2","author":"Forsgren","year":"2015","journal-title":"Eur. J. Radiol. Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1111\/jgh.13263","article-title":"Performance of magnetic resonance elastography in primary sclerosing cholangitis: MRE in PSC","volume":"31","author":"Eaton","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/MCG.0000000000001433","article-title":"Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated with Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients with Primary Biliary Cholangitis","volume":"55","author":"Osman","year":"2020","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1148\/radiology.149.1.6412283","article-title":"Primary sclerosing cholangitis: Findings on cholangiography and pancreatography","volume":"149","author":"MacCarty","year":"1983","journal-title":"Radiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2214\/ajr.157.3.1651643","article-title":"Primary sclerosing cholangitis: A modified classification of cholangiographic findings","volume":"157","author":"Majoie","year":"1991","journal-title":"Am. J. Roentgenol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF01887799","article-title":"Sclerosing cholangitis: Broad spectrum of radiographic features","volume":"9","author":"Chen","year":"1984","journal-title":"Gastrointest. Radiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/gut.51.4.562","article-title":"Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population","volume":"51","author":"Ponsioen","year":"2002","journal-title":"Gut"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2214\/ajr.157.5.1927817","article-title":"Primary sclerosing cholangitis: Value of cholangiography in determining the prognosis","volume":"157","author":"Craig","year":"1991","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Vitellas, K.M., Keogan, M.T., Freed, K.S., Enns, R.A., Spritzer, C.E., Baillie, J.M., and Nelson, R.C. (2000). Radiologic manifestations of sclerosing cholangitis with emphasis on MR cholangiopancreatography. RadioGraphics, 20.","DOI":"10.1148\/radiographics.20.4.g00jl04959"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1443-1661.2012.01288.x","article-title":"Demonstration of retraction of the main papilla toward the biliary system in patients with primary sclerosing cholangitis with magnetic resonance cholangiopancreatography","volume":"24","author":"Parlak","year":"2012","journal-title":"Dig. Endosc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5152\/tjg.2014.5238","article-title":"Retraction of the main papilla toward the biliary system in patients with primary sclerosing cholangitis","volume":"25","author":"Parlak","year":"2015","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0168-8278(90)90113-6","article-title":"Cystic dilatation of intrahepatic bile ducts in primary sclerosing cholangitis","volume":"11","author":"Dubuc","year":"1990","journal-title":"J. Hepatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.3748\/wjg.14.6748","article-title":"An unusual presentation of primary sclerosing cholangitis","volume":"14","author":"Goldwire","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_43","first-page":"476","article-title":"Primary sclerosing cholangitis presenting as recurrent cholangitis and right hepatic duct outpouching","volume":"148","year":"2012","journal-title":"Gac. Med. Mex."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"792","DOI":"10.4318\/tjg.2012.0496","article-title":"Unusual cholangiographic findings in a patient with primary sclerosing cholangitis: Cystic dilatation","volume":"23","author":"Parlak","year":"2012","journal-title":"Turk. J. Gastroenterol. Off. J. Turk. Soc. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-1999-13670","article-title":"Primary sclerosing cholangitis mimicking choledocal cyst type 1 in a young patient","volume":"31","author":"Siegel","year":"1999","journal-title":"Endoscopy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-2007-1010726","article-title":"Detection of large intrahepatic cholangiectases in patients with primary sclerosing cholangitis by endoscopic retrograde cholangiography","volume":"22","author":"Theilmann","year":"1990","journal-title":"Endoscopy"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s00330-018-5697-3","article-title":"Intrahepatic cystic biliary dilatation constitutes a significant prognostic factor in patients with primary sclerosing cholangitis","volume":"29","author":"Nguyen","year":"2018","journal-title":"Eur. Radiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-2559.1991.tb00046.x","article-title":"The spectrum of bile duct lesions in end-stage primary sclerosing cholangitis","volume":"19","author":"Harrison","year":"1991","journal-title":"Histopathology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2214\/ajr.171.4.9762990","article-title":"MR cholangiography in primary sclerosing cholangitis","volume":"171","author":"Ernst","year":"1998","journal-title":"Am. J. Roentgenol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.gie.2005.12.034","article-title":"Diagnosis of primary sclerosing cholangitis: A blinded comparative study using magnetic resonance cholangiography and endoscopic retrograde cholangiography","volume":"64","author":"Moff","year":"2006","journal-title":"Gastrointest. Endosc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0168-8278(00)80002-1","article-title":"Magnetic resonance cholangiography in patients with biliary disease: Its role in primary sclerosing cholangitis","volume":"33","author":"Angulo","year":"2000","journal-title":"J. Hepatol."},{"key":"ref_52","first-page":"514","article-title":"Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis","volume":"4","author":"Berstad","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1440-1746.2001.02432.x","article-title":"Imaging and clinical characteristics of focal atrophy of segments 2 and 3 in primary sclerosing cholangitis","volume":"16","author":"Caldwell","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jhep.2007.11.019","article-title":"Gallbladder disease in patients with primary sclerosing cholangitis","volume":"48","author":"Said","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2214\/ajr.150.3.571","article-title":"Gallbladder disease in patients with primary sclerosing cholangitis","volume":"150","author":"Brandt","year":"1988","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1572-0241.2002.05677.x","article-title":"In primary sclerosing cholangitis, gallbladder polyps are frequently malignant","volume":"97","author":"Buckles","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.3748\/wjg.15.3498","article-title":"Gallbladder emptying in patients with primary sclerosing cholangitis","volume":"15","author":"Said","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/gut.39.4.594","article-title":"Increased gall bladder volume in primary sclerosing cholangitis","volume":"39","author":"Portincasa","year":"1996","journal-title":"Gut"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100649","DOI":"10.1016\/j.jhepr.2022.100649","article-title":"Protective potential of the gallbladder in primary sclerosing cholangitis","volume":"5","author":"Cazzagon","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.26620","article-title":"Radiologic course of primary sclerosing cholangitis: Assessment by three-dimensional magnetic resonance cholangiography and predictive features of progression","volume":"59","author":"Ruiz","year":"2014","journal-title":"Hepatology"},{"key":"ref_61","first-page":"2785","article-title":"Simple Magnetic Resonance Scores Associate with Outcomes of Patients With Primary Sclerosing Cholangitis","volume":"17","author":"Lemoinne","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.14309\/ajg.0000000000000461","article-title":"The Complementary Value of Magnetic Resonance Imaging and Vibration-Controlled Transient Elastography for Risk Stratification in Primary Sclerosing Cholangitis","volume":"114","author":"Cazzagon","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/apt.14797","article-title":"Follow-up magnetic resonance imaging\/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: Challenging for experts to interpret","volume":"48","author":"Zenouzi","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1007\/s00330-020-07323-5","article-title":"Fully automated detection of primary sclerosing cholangitis (PSC)-compatible bile duct changes based on 3D magnetic resonance cholangiopancreatography using machine learning","volume":"31","author":"Ringe","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e220160","DOI":"10.1148\/ryai.220160","article-title":"DeePSC: A Deep Learning Model for Automated Diagnosis of Primary Sclerosing Cholangitis at Two-dimensional MR Cholangiopancreatography","volume":"5","author":"Ragab","year":"2023","journal-title":"Radiol. Artif. Intell."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"100577","DOI":"10.1016\/j.jhepr.2022.100577","article-title":"Quantitative magnetic resonance cholangiopancreatography metrics are associated with disease severity and outcomes in people with primary sclerosing cholangitis","volume":"4","author":"Cazzagon","year":"2022","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"ref_67","first-page":"373","article-title":"A quantitative MRCP-derived score for medium-term outcome prediction in primary sclerosing cholangitis","volume":"55","author":"Cristoferi","year":"2023","journal-title":"Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1148\/radiology.156.1.2988012","article-title":"Cholangiocarcinoma complicating primary sclerosing cholangitis: Cholangiographic appearances","volume":"156","author":"MacCarty","year":"1985","journal-title":"Radiology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/13651820701504207","article-title":"Differentiation between benign and malignant hilar obstructions using laboratory and radiological investigations: A prospective study","volume":"9","author":"Saluja","year":"2007","journal-title":"HPB"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/hep.22441","article-title":"Utility of serum tumor markers, imaging, and biliary cytology for detecting cholangiocarcinoma in primary sclerosing cholangitis","volume":"48","author":"Charatcharoenwitthaya","year":"2008","journal-title":"Hepatology"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2009). EASL Clinical Practice Guidelines: Management of cholestatic liver diseases. J. Hepatol., 51, 237\u2013267.","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.23294","article-title":"Diagnosis and management of primary sclerosing cholangitis","volume":"51","author":"Chapman","year":"2010","journal-title":"Hepatology"},{"key":"ref_73","first-page":"170","article-title":"Autoimmune biliary diseases: Primary biliary cholangitis and primary sclerosing cholangitis","volume":"113","author":"Sarcognato","year":"2021","journal-title":"Pathol.\u2014J. Ital. Soc. Anat. Pathol. Diagn. Cytopathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/hep.28256","article-title":"Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process","volume":"63","author":"Ponsioen","year":"2016","journal-title":"Hepatology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.jhep.2015.06.008","article-title":"Applicability and prognostic value of histologic scoring systems in primary sclerosing cholangitis","volume":"63","author":"Verheij","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/hep.28963","article-title":"Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study","volume":"65","author":"Arola","year":"2017","journal-title":"Hepatology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2001.22131","article-title":"Autoimmune hepatitis\/sclerosing cholangitis overlap syndrome in childhood: A 16-year prospective study","volume":"33","author":"Gregorio","year":"2001","journal-title":"Hepatology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00000478-200303000-00008","article-title":"The extrahepatic bile duct lesions in end-stage primary sclerosing cholangitis","volume":"27","author":"Katabi","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep.1840010612","article-title":"Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis","volume":"1","author":"Ludwig","year":"1981","journal-title":"Hepatology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1440-1827.2009.02500.x","article-title":"Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement","volume":"60","author":"Nakanuma","year":"2010","journal-title":"Pathol. Int."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/MCG.0b013e31827234e4","article-title":"Application and Validation of a New Histologic Staging and Grading System for Primary Biliary Cirrhosis","volume":"47","author":"Harada","year":"2013","journal-title":"J. Clin. Gastroenterol."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/10\/1\/5\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:41:45Z","timestamp":1760103705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/10\/1\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,7]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["tomography10010005"],"URL":"https:\/\/doi.org\/10.3390\/tomography10010005","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,7]]}}}