{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:06:35Z","timestamp":1760058395870,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Objectives: This study aims to assess the potential role of the ultrasound (US) monochromatic Superb Microvascular Index (mSMI) to predict malignancy of solid focal lesions, correlating the vascular index (VI) with bioptic histological results. Methods: In this single-center retrospective analysis, patients undergoing percutaneous US-guided biopsy of solid lesions were considered. Biopsy indication was given by a multidisciplinary team evaluation based on clinical radiological data. Exclusion criteria were: unfeasible SMI evaluations due to poor respiratory compliance, locations not appreciable with the SMI, previous antiangiogenetic chemo\/immunotherapies, and inconclusive histological reports. The mSMI examination was conducted in order to visualize extremely low-velocity flows with a high resolution and high frame rate; the VI was semi-automatically calculated. All bioptic procedures were performed under sole US guidance using 16G or 18G needles, immediately after mSMI assessment. Results: Forty-four patients were included (mean age: 64 years; 27 males, 17 females). Liver (15\/43), kidneys (9\/43), and lymph nodes (6\/43) were the most frequent targets. At histopathological analysis, 7 lesions were benign and 37 malignant, metastasis being the most represented. The VI calculated in malignant lesions was statistically higher compared to benign lesions (35.45% and 11% in malignant and benign, respectively; p-value 0.013). A threshold VI value of 15.4% was identified to differentiate malignant lesions. The overall diagnostic accuracy of the VI with the mSMI was 0.878, demonstrating a high level of diagnostic accuracy. Conclusions: In this study, the mSMI analysis of solid focal lesions undergoing percutaneous biopsy significantly correlated with histological findings in terms of malignant\/benign predictive value, reflecting histological vascular changes in malignant lesions.<\/jats:p>","DOI":"10.3390\/tomography11040043","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:59:00Z","timestamp":1744091940000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Monochromatic Superb Microvascular Index to Predict Malignancy of Solid Focal Lesions: Correlation Between Vascular Index and Histological Bioptic Findings"],"prefix":"10.3390","volume":"11","author":[{"given":"Francesco","family":"Giurazza","sequence":"first","affiliation":[{"name":"Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-9305","authenticated-orcid":false,"given":"Luigi","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"D\u2019Antuono","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-8148","authenticated-orcid":false,"given":"Fabio","family":"Corvino","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-1139","authenticated-orcid":false,"given":"Antonio","family":"Borzelli","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4226-4579","authenticated-orcid":false,"given":"Claudio","family":"Carrubba","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Niola","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Department, Cardarelli Hospital, Via Antonio Cardarelli 9, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.acra.2020.03.032","article-title":"Clinical Applications of Superb Microvascular Imaging in the Superficial Tissues and Organs: A Systematic Review","volume":"28","author":"Fu","year":"2021","journal-title":"Acad. Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20160546","DOI":"10.1259\/bjr.20160546","article-title":"Superb microvascular imaging in diagnosis of breast lesions: A comparative study with contrast-enhanced ultrasonographic microvascular imaging","volume":"89","author":"Xiao","year":"2016","journal-title":"Br. J. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.14366\/usg.19033","article-title":"Comparison of MicroFlow Imaging with color and power Doppler imaging for detecting and characterizing blood flow signals in hepatocellular carcinoma","volume":"39","author":"Bae","year":"2020","journal-title":"Ultrasonography"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1016\/j.ejrad.2016.09.026","article-title":"Superb microvascular imaging technology for ultrasound examinations: Initial experiences for hepatic tumors","volume":"85","author":"Lee","year":"2016","journal-title":"Eur. J. Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/jum.15299","article-title":"Superb Microvascular Imaging Improves Detection of Vascularity in Indeterminate Renal Masses","volume":"39","author":"Leong","year":"2020","journal-title":"J. Ultrasound Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.14366\/usg.17043","article-title":"Up-to-date Doppler techniques for breast tumor vascularity: Superb Microvascular Imaging and contrast-enhanced ultrasound","volume":"37","author":"Park","year":"2018","journal-title":"Ultrasonography"},{"key":"ref_7","unstructured":"Lyshchik, A. (2019). Speciality Imaging: Fundamentals of CEUS, Elsevier."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1007\/s00259-010-1449-6","article-title":"Contrast-enhanced ultrasound for molecular imaging of angiogenesis","volume":"37","author":"Eisenbrey","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_9","first-page":"169","article-title":"Use of new microcirculation software allows the demonstration of dermis vascularization","volume":"26","author":"Catalano","year":"2023","journal-title":"J. Ultrasound Mar."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/RUQ.0000000000000533","article-title":"Comparison of Superb Microvascular Imaging With Other Doppler Methods in Assessment of Testicular Vascularity in Cryptorchidism","volume":"36","author":"Keskin","year":"2020","journal-title":"Ultrasound Q."},{"key":"ref_11","first-page":"212","article-title":"A comparison between the superb microvascular imaging technique and conventional Doppler ultrasound in evaluating chronic allograft damage in renal transplant recipients","volume":"29","author":"Gurbuz","year":"2023","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1002\/jum.15010","article-title":"Differentiation Between Malignant and Benign Lymph Nodes: Role of Superb Microvascular Imaging in the Evaluation of Cervical Lymph Nodes","volume":"38","author":"Sim","year":"2019","journal-title":"J. Ultrasound Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.3748\/wjg.v23.i43.7765","article-title":"Application of superb microvascular imaging in focal liver lesions","volume":"23","author":"He","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.21037\/tau.2019.11.15","article-title":"Impact of a novel ultrasound microvascular imaging and elastography on prostate cancer classification","volume":"8","author":"Shen","year":"2019","journal-title":"Transl. Androl. Urol."},{"key":"ref_15","first-page":"655","article-title":"Application of superb microvascular imaging in differential diagnosis of cervical lymph node lesions","volume":"32","author":"Lei","year":"2016","journal-title":"Chin. J. Med. Imaging Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s40644-019-0277-6","article-title":"Superb microvascular imaging technique in depicting vascularity in focal liver lesions: More hypervascular supply patterns were depicted in hepatocellular carcinoma","volume":"19","author":"Yang","year":"2019","journal-title":"Cancer Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s40477-021-00561-3","article-title":"Scrubbing needles: A simple and costless technique to improve needle tip visibility during US-guided liver interventions","volume":"25","author":"Giurazza","year":"2022","journal-title":"J. Ultrasound"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20181038","DOI":"10.1259\/bjr.20181038","article-title":"Superb microvascular imaging is a rational choice for accurate Bosniak classification of renal cystic masses","volume":"92","author":"Mu","year":"2019","journal-title":"Br. J. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1502","DOI":"10.1097\/MD.0000000000001502","article-title":"The Diagnostic Value of Superb Microvascular Imaging (SMI) in Detecting Blood Flow Signals of Breast Lesions: A Preliminary Study Comparing SMI to Color Doppler Flow Imaging","volume":"94","author":"Ma","year":"2015","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/RUQ.0000000000000156","article-title":"A Novel Microvascular Flow Technique: Initial Results in Thyroids","volume":"32","author":"Machado","year":"2016","journal-title":"Ultrasound Q."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1002\/jum.14983","article-title":"Evaluation of Ovarian Vascularity in Children by Using the \u201cSuperb Microvascular Imaging\u201d Ultrasound Technique in Comparison With Conventional Doppler Ultrasound Techniques","volume":"38","author":"Ayaz","year":"2019","journal-title":"J. Ultrasound Med."},{"key":"ref_22","first-page":"20170601","article-title":"The value of superb microvascular imaging in differentiating benign renal mass from malignant renal tumor: A retrospective study","volume":"91","author":"Mao","year":"2018","journal-title":"Br. J. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.21037\/qims-21-383","article-title":"Comparison of superb microvascular imaging (SMI) quantified with ImageJ to quantified contrast-enhanced ultrasound (qCEUS) in liver metastases-a pilot study","volume":"12","author":"Kratzer","year":"2022","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chartampilas, E., Rafailidis, V., Georgopoulou, V., Kalarakis, G., Hatzidakis, A., and Prassopoulos, P. (2022). Current Imaging Diagnosis of Hepatocellular Carcinoma. Cancers, 14.","DOI":"10.3390\/cancers14163997"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.3748\/wjg.v22.i26.6057","article-title":"Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique","volume":"22","author":"Kuroda","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Tang, Y., Zhang, G., Zhang, J., Li, Y., and Jiang, Z. (2023). Quantitative analysis of superb microvascular imaging for monitoring tumor response to chemoradiotherapy in locally advanced cervical cancer. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1074173"}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/11\/4\/43\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:10:27Z","timestamp":1760029827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/11\/4\/43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["tomography11040043"],"URL":"https:\/\/doi.org\/10.3390\/tomography11040043","relation":{},"ISSN":["2379-139X"],"issn-type":[{"type":"electronic","value":"2379-139X"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}