{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:36:50Z","timestamp":1760060210100,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Objectives: This study aimed to investigate the consistency of lesion identification by Prostate Imaging Reporting and Data System (PI-RADS) and the related clinical and histological characteristics in a high-volume tertiary care center. Materials and methods: The analysis used real-world data from 111 patients between 2018 and 2022. Each patient underwent two multiparametric magnetic resonance imaging (MRI) scans of the prostate at different institutions with a median interval of 42 days between the scans, followed by an MRI-fused biopsy conducted 7 days after the second MRI. Results: The PI-RADS classifications assigned to the index lesions in the in-house prostate MRI were as follows: PI-RADS V, 33.3% (n = 37); PI-RADS IV, 49.5% (n = 55); PI-RADS III, 12.6% (n = 14); and PI-RADS II, 4.5% (n = 5). Cancer detection rates for randomized and\/or targeted biopsies were 91.9% (n = 34) for PI-RADS V, 65.5% (n = 36) for PI-RADS IV, 21.4% (n = 3) for PI-RADS III, and 20% (n = 1) for PI-RADS II. Overall, malignant histology was observed in 64.9% (n = 72) of the targeted lesions and 57.7% (n = 64) of the randomized biopsies. In the first performed, external MRI, 18% (n = 20) and 10.8% (n = 12) of the patients were classified in the higher and lower PI-RADS categories, respectively. The biopsy plan was adjusted for 57 patients (51.4%); nevertheless, any cancer could have possibly been identified regardless of the adjustments. Conclusion: The 6-week interval between the MRI scans did not affect the quality of the biopsy results significantly.<\/jats:p>","DOI":"10.3390\/tomography11080092","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:56:06Z","timestamp":1755590166000},"page":"92","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in PI-RADS Classification of Prostate Cancer Based on mpMRI Scans Taken 6 Weeks Apart"],"prefix":"10.3390","volume":"11","author":[{"given":"Justine","family":"Schoch","sequence":"first","affiliation":[{"name":"Department of Urology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola","family":"D\u00fcring","sequence":"additional","affiliation":[{"name":"Department of Urology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wiedmann","sequence":"additional","affiliation":[{"name":"Department of Urology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Overhoff","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-0167","authenticated-orcid":false,"given":"Daniel","family":"Dillinger","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Waldeck","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Ulrich","family":"Schmelz","sequence":"additional","affiliation":[{"name":"Department of Urology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6033-6364","authenticated-orcid":false,"given":"Tim","family":"Nestler","sequence":"additional","affiliation":[{"name":"Department of Urology, Federal Armed Forces Hospital Koblenz, Ruebenacher Strasse 170, 56072 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of Prostate Cancer","volume":"10","author":"Rawla","year":"2019","journal-title":"World J. 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Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): A paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis","volume":"378","author":"Kasivisvanathan","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.eururo.2015.08.052","article-title":"PI-RADS Prostate Imaging\u2014Reporting and Data System: 2015, Version 2","volume":"69","author":"Weinreb","year":"2016","journal-title":"Eur. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.acra.2020.01.031","article-title":"Quality of Prostate MRI: Is the PI-RADS Standard Sufficient?","volume":"28","author":"Sackett","year":"2021","journal-title":"Acad. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"894.e19","DOI":"10.1016\/j.crad.2019.03.026","article-title":"A multicentre assessment of prostate MRI quality and compliance with UK and international standards","volume":"74","author":"Burn","year":"2019","journal-title":"Clin. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"110923","DOI":"10.1016\/j.ejrad.2023.110923","article-title":"Inter-reader agreement of the prostate imaging quality (PI-QUAL) score for basic readers in prostate MRI: A multi-center study","volume":"165","author":"Basar","year":"2023","journal-title":"Eur. J. 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Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/RLI.0000000000000382","article-title":"Multiparametric Magnetic Resonance Imaging of the Prostate: Repeatability of Volume and Apparent Diffusion Coefficient Quantification","volume":"52","author":"Fedorov","year":"2017","journal-title":"Investig. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1007\/s00261-015-0396-x","article-title":"Short-term reproducibility of apparent diffusion coefficient estimated from diffusion-weighted MRI of the prostate","volume":"40","author":"Sadinski","year":"2015","journal-title":"Abdom. 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Urol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s40644-024-00734-3","article-title":"MRI-guided in-bore biopsy of the prostate\u2014Defining the optimal number of cores needed","volume":"24","author":"Gross","year":"2024","journal-title":"Cancer Imaging"}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/11\/8\/92\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:29:54Z","timestamp":1760034594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/11\/8\/92"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["tomography11080092"],"URL":"https:\/\/doi.org\/10.3390\/tomography11080092","relation":{},"ISSN":["2379-139X"],"issn-type":[{"type":"electronic","value":"2379-139X"}],"subject":[],"published":{"date-parts":[[2025,8,18]]}}}