{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:19:38Z","timestamp":1790968778806,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Tomography"],"abstract":"<jats:p>Objective: This study aimed to evaluate the hepatic volume, iodine concentration, and extracellular volume (ECV) of each hepatic segment in cirrhotic patients using three-dimensional (3D) volumetric iodine mapping of the liver segment derived from contrast-enhanced dual-energy CT (DECT) superimposed on extracted color-coded CT liver segments in comparison with non-cirrhotic patients. Methods: The study population consisted of 66 patients, 34 with cirrhosis and 32 without cirrhosis. Using 3D volumetric iodine mapping of the liver segment derived from contrast-enhanced DECT superimposed on extracted color-coded CT liver segments, the volume and iodine concentration of each hepatic segment in the portal venous phase (PVP) and equilibrium phase (EP), the difference in iodine concentration between PVP and EP (ICPVP-liver\u2014ICEP-liver), and ECV fractions were compared between cirrhotic and non-cirrhotic groups. Results: The iodine concentration was not significantly different in all hepatic segments between the cirrhotic and non-cirrhotic groups. Conversely, the difference in iodine concentration between PVP and EP (ICPVP-liver\u2014ICEP-liver) was significantly smaller in the cirrhosis group than in the non-cirrhosis group for all hepatic segments (p &lt; 0.001). The ECV fraction of the left medial segment was significantly higher in the cirrhosis group than in the non-cirrhotic group ([26.4 \u00b1 7.6] vs. [23.1 \u00b1 5.1]; p &lt; 0.05). Conclusions: The decreased difference in iodine concentration between PVP and EP calculated from 3D volumetric iodine mapping of the liver segment using DECT may be a clinically useful indicator for evaluating patients with compensated cirrhosis, suggesting a combined effect of a reduced portal venous flow and increased interstitial space associated with fibrosis.<\/jats:p>","DOI":"10.3390\/tomography11100109","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:49:34Z","timestamp":1759142974000},"page":"109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Three-Dimensional Volumetric Iodine Mapping of the Liver Segment Derived from Contrast-Enhanced Dual-Energy CT for the Assessment of Hepatic Cirrhosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Yosuke","family":"Kawano","sequence":"first","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-4257","authenticated-orcid":false,"given":"Masahiro","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-9495","authenticated-orcid":false,"given":"Mayumi","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4183-4523","authenticated-orcid":false,"given":"Haruka","family":"Kiyoyama","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Kamamura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Furutani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Yamaguchi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gines","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1159\/000374098","article-title":"Hepatic Fibrosis: Emerging Therapies","volume":"33","author":"Friedman","year":"2015","journal-title":"Dig. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s11604-020-00978-6","article-title":"Morphometric changes and imaging findings of diffuse liver disease in relation to intrahepatic hemodynamics","volume":"38","author":"Ozaki","year":"2020","journal-title":"Jpn. J. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s11604-023-01388-0","article-title":"Liver cirrhosis: Relationship between fibrosis-associated hepatic morphological changes and portal hemodynamics using four-dimensional flow magnetic resonance imaging","volume":"41","author":"Higaki","year":"2023","journal-title":"Jpn. J. Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s11547-024-01833-8","article-title":"Automated hepatic steatosis assessment on dual-energy CT-derived virtual non-contrast images through fully-automated 3D organ segmentation","volume":"129","author":"Jeon","year":"2024","journal-title":"Radiol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1007\/s00330-020-06876-9","article-title":"Quantification of liver extracellular volume using dual-energy CT: Utility for prediction of liver-related events in cirrhosis","volume":"30","author":"Bak","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiol.2015142631","article-title":"Dual- and Multi-Energy CT: Principles, Technical Approaches, and Clinical Applications","volume":"276","author":"McCollough","year":"2015","journal-title":"Radiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/hepr.13205","article-title":"Dual-energy computed tomography for non-invasive staging of liver fibrosis: Accuracy of iodine density measurements from contrast-enhanced data","volume":"48","author":"Sofue","year":"2018","journal-title":"Hepatol. Rrs."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s002610000013","article-title":"Hepatic morphologic changes in cirrhosis: MR imaging findings","volume":"25","author":"Ito","year":"2000","journal-title":"Abdom. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s13244-010-0034-7","article-title":"MR imaging in liver cirrhosis: Classical and new approaches","volume":"1","author":"Delgado","year":"2010","journal-title":"Insights Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/jmri.20419","article-title":"Pre- and postprandial alterations of portal venous flow: Evaluation with single breath-hold three-dimensional half-Fourier fast spin-echo MR imaging and a selective inversion recovery tagging pulse","volume":"22","author":"Tsukuda","year":"2005","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1007\/s00330-021-07897-8","article-title":"Assessment of factors affecting washout appearance of hepatocellular carcinoma on CT","volume":"31","author":"Hwang","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109604","DOI":"10.1016\/j.ejrad.2021.109604","article-title":"Hepatic fibrosis grading with extracellular volume fraction from iodine mapping in spectral liver CT","volume":"137","author":"Yoon","year":"2021","journal-title":"Eur. J. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1007\/s00330-021-07706-2","article-title":"Liver fibrosis assessment with multiphasic dual-energy CT: Diagnostic performance of iodine uptake parameters","volume":"31","author":"Nagayama","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11604-019-00918-z","article-title":"Usefulness of iodine-blood material density images in estimating degree of liver fibrosis by calculating extracellular volume fraction obtained from routine dual-energy liver CT protocol equilibrium phase data: Preliminary experience","volume":"38","author":"Ito","year":"2020","journal-title":"Jpn. J. Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"109575","DOI":"10.1016\/j.ejrad.2021.109575","article-title":"Noninvasive assessment of liver fibrosis by dual-layer spectral detector CT","volume":"136","author":"Morita","year":"2021","journal-title":"Eur. J. Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.2214\/AJR.12.10039","article-title":"Contrast-enhanced CT quantification of the hepatic fractional extracellular space: Correlation with diffuse liver disease severity","volume":"201","author":"Zissen","year":"2013","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11547-019-01089-7","article-title":"Dual-source dual-energy CT in the evaluation of hepatic fractional extracellular space in cirrhosis","volume":"125","author":"Bottari","year":"2020","journal-title":"Radiol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1148\/radiol.14141435","article-title":"Equilibrium contrast-enhanced CT imaging to evaluate hepatic fibrosis: Initial validation by comparison with histopathologic sampling","volume":"275","author":"Bandula","year":"2015","journal-title":"Radiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1148\/radiol.2021204315","article-title":"Noninvasive Staging of Liver Fibrosis with Dual-Energy CT: Close but No Cigar","volume":"298","author":"Chandarana","year":"2021","journal-title":"Radiology"}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/11\/10\/109\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:02:54Z","timestamp":1759147374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/11\/10\/109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["tomography11100109"],"URL":"https:\/\/doi.org\/10.3390\/tomography11100109","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]}}}