{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:33:48Z","timestamp":1789421628121,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Background: We aimed to determine paranasal sinus volumes using 3D volumetric measurements and to evaluate the effect of anatomical variations on these volumes, ensuring balanced age and sex distribution during childhood. Methods: Thirteen age groups (0\u201316 years), each including 10 males and 10 females, were formed. After excluding sinus pathologies, a total of 260 subjects were randomly selected from CT head examinations. Right and left frontal, maxillary, and sphenoid sinus volumes were calculated using 3D Slicer software (version 5.6.2) following manual segmentation of axial CT slices. Also, the presence of right and left Agger Nasi cells, Haller cells, Onodi cells, and concha bullosa were recorded. Results: No significant difference was found between males and females in sinus volumes (p &gt; 0.05). Mean right and left maxillary sinus volumes were 6.23 cm3 and 6.27 cm3 (p = 0.551); frontal sinuses were 0.79 cm3 and 0.86 cm3 (p = 0.170); and sphenoid sinuses were 1.64 cm3 and 1.85 cm3 (p = 0.041). Sphenoid sinus pneumatization appeared in 30% of the 0\u20136-month group and in over 75% of older groups. Frontal pneumatization began at age 2\u20133 and exceeded 50% after age 4. Agger Nasi, Haller, Onodi cells, and concha bullosa were detected in 58.8%, 31.2%, 10%, and 22.3% of cases, respectively. Anatomical variations showed no significant effect on sinus volumes (p &gt; 0.05). Conclusions: We developed a paranasal sinus volume chart applicable to routine practice, showing that anatomical variations had no significant impact on the development. This is the first study to investigate the impact of anatomical variations on sinus development and volume, along with the age at which variations emerge, with a balanced distribution of age and sex.<\/jats:p>","DOI":"10.3390\/tomography12020015","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:48:30Z","timestamp":1769442510000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Paranasal Sinus Growth with 3D Volumetric Measurements and the Effect of Anatomic Variations on Sinus Volume in a Pediatric Population"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-2097","authenticated-orcid":false,"given":"Ercan","family":"Ayaz","sequence":"first","affiliation":[{"name":"Pediatric Radiology Division, Department of Radiology, Ba\u015fak\u015fehir \u00c7am & Sakura City Hospital, \u0130stanbul 34480, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irem","family":"Kavukoglu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ba\u015fak\u015fehir \u00c7am & Sakura City Hospital, \u0130stanbul 34480, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-2982","authenticated-orcid":false,"given":"Nazli Gulsum","family":"Akyel","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Division, Department of Radiology, Ba\u015fak\u015fehir \u00c7am & Sakura City Hospital, \u0130stanbul 34480, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Iturralde-Garrote, A., Sanz, J.L., Forner, L., Melo, M., and Puig-Herreros, C. (2023). Volumetric Changes of the Paranasal Sinuses with Age: A Systematic Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103355"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00276-016-1743-5","article-title":"Volumetric study of sphenoid sinuses: Anatomical analysis in helical computed tomography","volume":"39","author":"Oliveira","year":"2017","journal-title":"Surg. Radiol. Anat."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ca.20617","article-title":"CT study on morphometry of frontal sinus","volume":"21","author":"Tatlisumak","year":"2008","journal-title":"Clin. Anat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5603\/FM.a2022.0033","article-title":"Morphometric variants of the paranasal sinuses in a Mexican population: Expected changes according to age and gender","volume":"82","year":"2023","journal-title":"Folia Morphol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/lary.20804","article-title":"An assessment of sinonasal anatomic variants potentially associated with recurrent acute rhinosinusitis","volume":"120","author":"Alkire","year":"2010","journal-title":"Laryngoscope"},{"key":"ref_6","first-page":"244","article-title":"Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis","volume":"32","author":"Fadda","year":"2012","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2214\/AJR.14.13762","article-title":"CT of Anatomic Variants of the Paranasal Sinuses and Nasal Cavity: Poor Correlation With Radiologically Significant Rhinosinusitis but Importance in Surgical Planning","volume":"204","author":"Shpilberg","year":"2015","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijporl.2008.02.006","article-title":"The relationship between anatomical variations of the sino-nasal region and chronic sinusitis extension in children","volume":"72","year":"2008","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/lary.23705","article-title":"Frontal sinus septations predict the presence of supraorbital ethmoid cells","volume":"123","author":"Comer","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"404982","DOI":"10.1155\/2010\/404982","article-title":"The prevalence of concha bullosa and nasal septal deviation and their relationship to maxillary sinusitis by volumetric tomography","volume":"2010","author":"Smith","year":"2010","journal-title":"Int. J. Dent."},{"key":"ref_11","first-page":"206","article-title":"Anatomic variations of the paranasal sinuses in the general pediatric population","volume":"57","author":"Cohen","year":"2019","journal-title":"Rhinology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.anl.2024.08.007","article-title":"Assessing volume growth of paranasal sinuses and nasal cavity in children using three-dimensional imaging software","volume":"51","author":"Yamakawa","year":"2024","journal-title":"Auris Nasus Larynx"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"61","author":"Altman","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ca.23888","article-title":"Pediatric paranasal sinuses-Development, growth, pathology, & functional endoscopic sinus surgery","volume":"35","author":"Lee","year":"2022","journal-title":"Clin. Anat."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1097\/SCS.0000000000002304","article-title":"The Age-Related Development of Maxillary Sinus in Children","volume":"27","author":"Ertekin","year":"2016","journal-title":"J. Craniofac Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.ijporl.2010.08.018","article-title":"Volumetric study in the development of paranasal sinuses by CT imaging in Asian: A pilot study","volume":"74","author":"Park","year":"2010","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00330-001-1218-9","article-title":"Paranasal sinuses in children: Size evaluation of maxillary, sphenoid, and frontal sinuses by magnetic resonance imaging and proposal of volume index percentile curves","volume":"12","author":"Barghouth","year":"2002","journal-title":"Eur. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.ijporl.2015.05.032","article-title":"Development of the maxillary sinus from birth to age 18. Postnatal growth pattern","volume":"79","author":"Kociemba","year":"2015","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_19","first-page":"1","article-title":"European position paper on the anatomical terminology of the internal nose and paranasal sinuses-a free resource","volume":"24","author":"Lund","year":"2014","journal-title":"Rhinol. Suppl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/00016480600606681","article-title":"The relationship between anatomic variations of paranasal sinuses and chronic sinusitis in children","volume":"126","author":"Kim","year":"2006","journal-title":"Acta Otolaryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13005-022-00340-3","article-title":"A comparative study of paranasal sinus and nasal cavity anatomic variations between the Polish and Turkish Cypriot Population with CBCT","volume":"18","author":"Gruszka","year":"2022","journal-title":"Head. Face Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"687582","DOI":"10.1155\/2013\/687582","article-title":"The prevalence of frontal cells and their relation to frontal sinusitis: A radiological study of the frontal recess area","volume":"2013","author":"Eweiss","year":"2013","journal-title":"ISRN Otolaryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.3390\/tomography8060233","article-title":"Three-Dimensional Volumetric Analysis of Frontal Ethmoidal Cells and Evaluation of Influential Factors: A Helical Computed Tomography Study","volume":"8","author":"Ricardo","year":"2022","journal-title":"Tomography"},{"key":"ref_24","first-page":"32","article-title":"Variations in paranasal sinus anatomy: Implications for the pathophysiology of chronic rhinosinusitis and safety of endoscopic sinus surgery","volume":"38","author":"Nouraei","year":"2009","journal-title":"J. Otolaryngol. Head. Neck Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e312101422220","DOI":"10.33448\/rsd-v10i14.22220","article-title":"Age- and sex-related changes of the volume of maxillary sinuses quantified via cone beam computed tomography","volume":"10","author":"Franco","year":"2021","journal-title":"Res. Soc. Dev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ozsoy, S.C., Bahrilli, S., Altiparmak, F., Yilmaz, H., Yuksel, I.B., Arslan, M.E., and Altindag, A. (2025). Volumetric evaluation of the maxillary sinus using cone-beam computed tomography. BMC Oral Health, 25.","DOI":"10.1186\/s12903-025-07221-6"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"110334","DOI":"10.1016\/j.ijporl.2020.110334","article-title":"Using 3D-reconstruction to analyse typical growth trends of the maxillary sinus in children","volume":"138","author":"Lee","year":"2020","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_28","first-page":"197","article-title":"Development of the paranasal air sinuses in a South African population utilising three dimensional (3D) reconstructed models","volume":"21","author":"Rennie","year":"2017","journal-title":"Eur. J. Anat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2500\/ajra.2011.25.3552","article-title":"Paranasal sinus development in children: A magnetic resonance imaging analysis","volume":"25","author":"Adibelli","year":"2011","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5144\/0256-4947.2005.41","article-title":"Morphometric examination of the paranasal sinuses and mastoid air cells using computed tomography","volume":"25","author":"Karakas","year":"2005","journal-title":"Ann. Saudi Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.7150\/ijms.68095","article-title":"Volumetric evaluation of the sphenoid sinus among different races in the Southeast Asian (SEA) population: A computerized tomography study","volume":"20","author":"Tuang","year":"2023","journal-title":"Int. J. Med. Sci."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/12\/2\/15\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:36:12Z","timestamp":1769682972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/12\/2\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["tomography12020015"],"URL":"https:\/\/doi.org\/10.3390\/tomography12020015","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]}}}