{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:10:28Z","timestamp":1779448228599,"version":"3.53.1"},"reference-count":22,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP23K10818"],"award-info":[{"award-number":["JP23K10818"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Objectives: This study investigated whether visual field abnormalities are present in eyes with suspected nasal optic disc hypoplasia (NOH) by using fundus photography and optical coherence tomography (OCT). Methods: NOH was diagnosed using the following criteria: (1) small optic disc, (2) nasal optic disc pallor or optic disc margin irregularity, (3) wedge-shaped temporal visual field defects extending from Mariotte\u2019s blind spot, and (4) reduced nasal circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Eyes fulfilling criteria 1, 2, and 4 without visual field abnormalities were classified as pseudo-NOH (pNOH), whereas eyes without visual field or cpRNFL abnormalities were considered normal. Nasal cpRNFL thickness was measured using OCT, radial peripapillary capillary (RPC) density was assessed using OCT angiography (OCTA), visual field testing was performed, and optic disc blood flow velocity was evaluated using the mean blur rate (MBR) and laser speckle flowgraphy (LSFG). Results: Seven eyes with NOH, 13 eyes with pNOH, and 24 normal right eyes were included. Nasal cpRNFL thickness and MBR were significantly reduced in both the NOH and pNOH groups compared with the normal group, with no significant difference between the NOH and pNOH groups. Nasal RPC density was significantly lower in the NOH group than in both the pNOH and normal groups, and no significant difference was observed between the pNOH and normal groups. Conclusions: Even when NOH was suspected from fundus, LSFG, and OCT C-scan findings, visual field abnormalities were not consistently present. Differences in RPC density measured using OCTA may have contributed to this variability. This study examined whether suspected nasal optic disc hypoplasia (NOH) is always associated with visual field defects. Using fundus imaging, OCT, OCT angiography, and laser speckle flowgraphy, we compared eyes with NOH, pseudo-NOH, and normal eyes. Although structural changes such as reduced nasal nerve fiber layer thickness and decreased blood flow were observed in both NOH and pseudo-NOH, visual field abnormalities were not consistently present. Notably, reduced radial peripapillary capillary density was specific to NOH, suggesting that vascular differences may explain variability in visual function. These findings highlight the importance of multimodal imaging in NOH evaluation.<\/jats:p>","DOI":"10.3390\/tomography12050073","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:07:47Z","timestamp":1779444467000},"page":"73","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radial Peripapillary Capillary Density Involved in Nasal Optic Disc Thinning and Visual Field Abnormalities Using Optical Coherence Tomography Angiography"],"prefix":"10.3390","volume":"12","author":[{"given":"Miki","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Orthoptics and Visual Sciences, Faculty of Health and Medical Sciences, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Orthoptics and Visual Sciences, Faculty of Health and Medical Sciences, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"},{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusei","family":"Yakushiji","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazuna","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichika","family":"Kawazu","sequence":"additional","affiliation":[{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yoshitomi","sequence":"additional","affiliation":[{"name":"Department of Orthoptics and Visual Sciences, Faculty of Health and Medical Sciences, Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"},{"name":"Department of Orthoptics, Faculty of Medicine, Fukuoka International University of Health and Welfare, Sawara-ku, Fukuoka 814-0001, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ajo.2022.10.016","article-title":"Combining optical coherence tomography and optical coherence tomography angiography longitudinal data for the detection of visual field progression in glaucoma","volume":"246","author":"Kamalipour","year":"2023","journal-title":"Am. 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Rep."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/12\/5\/73\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:58:45Z","timestamp":1779447525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/12\/5\/73"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["tomography12050073"],"URL":"https:\/\/doi.org\/10.3390\/tomography12050073","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}