{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:35:33Z","timestamp":1785418533821,"version":"3.56.0"},"reference-count":22,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Rudi Schulte Research Institute"},{"DOI":"10.13039\/100009797","name":"Barrow Neurological Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009797","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01fwrsq33","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Background\/Objectives: Normal pressure hydrocephalus (NPH) is a treatable cause of gait impairment and fall risk in older adults, yet it remains frequently underdiagnosed. This study aimed to validate an automated measurement of the callosal angle, a recognized imaging marker of NPH, adapted for use on routine head computed tomography (CT). Methods: We performed a retrospective analysis of 198 patients with probable NPH, confirmed by gait improvement following lumbar tap test, and 198 age- and sex-matched controls presenting with headache and negative head CT findings (mean age 74 \u00b1 7 years; 60% male in both groups). Manual callosal angle measurements were independently obtained by trained residents and reviewed by neuroradiologists. Automated and manual measurements were compared using intraclass correlation, and diagnostic performance was assessed across threshold values. Results: Automated callosal angle measurements demonstrated strong agreement with manual measurements (ICC = 0.90). Using an automated callosal angle threshold of &lt;90\u00b0, diagnostic accuracy was 84.1%, with sensitivity of 90.4% and specificity of 77.8%. Optimization to a 95\u00b0 threshold yielded an accuracy of 85.9%, with both sensitivity and specificity of 85.9%. The area under the receiver operating characteristic curve was 0.915 (95% CI, 0.897\u20130.933). Conclusions: Automated callosal angle assessment on routine head CT provides reliable and scalable detection of NPH, supporting its use as a screening tool to facilitate earlier diagnosis and treatment of a potentially reversible cause of dementia.<\/jats:p>","DOI":"10.3390\/tomography12060083","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:08:02Z","timestamp":1780535282000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening for Normal Pressure Hydrocephalus on Head CT Using Automated Callosal Angle Assessment"],"prefix":"10.3390","volume":"12","author":[{"given":"Sennett","family":"Yang","sequence":"first","affiliation":[{"name":"School of Medicine, Creighton University, Phoenix Campus, Phoenix, AZ 85004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazza","family":"Jamil","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diep","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiology, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Radiology, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Foldes","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-3699","authenticated-orcid":false,"given":"Jacob J.","family":"Knittel","sequence":"additional","affiliation":[{"name":"Department of Radiology, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddie","family":"Muenzer","sequence":"additional","affiliation":[{"name":"Arizona State University, Phoenix, AZ 85004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clay M.","family":"Oliver","sequence":"additional","affiliation":[{"name":"School of Medicine, Creighton University, Phoenix Campus, Phoenix, AZ 85004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8720-6789","authenticated-orcid":false,"given":"Raza","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-4430","authenticated-orcid":false,"given":"Justin L.","family":"Hoskin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7010-2318","authenticated-orcid":false,"given":"Matthew T.","family":"Borzage","sequence":"additional","affiliation":[{"name":"Fetal and Neonatal Institute, Division of Neonatology, Children\u2019s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA"},{"name":"Alfred E. Mann Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA 90089-1111, USA"},{"name":"Department of Regulatory and Quality Sciences, University of Southern California Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los Angeles, CA 90033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4449-2468","authenticated-orcid":false,"given":"Kevin S.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, AZ 85013, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Davis, A., Luciano, M., Moghekar, A., and Yasar, S. (2021). 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Sci."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/12\/6\/83\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:36:12Z","timestamp":1780634172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/12\/6\/83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["tomography12060083"],"URL":"https:\/\/doi.org\/10.3390\/tomography12060083","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]}}}