{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:19:59Z","timestamp":1787746799702,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Biomedical Research Institute, Chung-Ang University Hospital"},{"id":[{"id":"https:\/\/ror.org\/04gr4mh63","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Objectives: To assess the clinical viability of compressed sensing magnetization, we prepared a rapid acquisition gradient echo (CS-MPRAGE) for brain volume measurement by comparing its scan time and image quality with standard MPRAGE. Methods: In this retrospective study, we analyzed a total of 40 morphologically normal MRIs from relatively young subjects (mean age 27.03 \u00b1 5.02, range 19~40, F:M = 33:7) who underwent both CS-MPRAGE and standard MPRAGE. MRI was performed with a 3T MR scanner using a 64-channel head coil. Volumetric data analysis was conducted using commercial AI-powered quantification software. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNRgray matter\/white matter) were measured and compared. Qualitative analysis based on overall image quality, deep gray matter delineation, artifacts, and gray\u2013white matter differentiation was rated on a five-point visual scoring system. Statistical analyses included paired t-tests, intraclass correlation coefficients (ICCs) and Pearson correlation. Results: CS-MPRAGE had a significantly shorter scan time than standard MPRAGE (1:46 vs. 5:20 min; p &lt; 0.001). Whole-brain volume was similar (standard-MPRAGE, 1176.89 \u00b1 105.36; CS-MPRAGE, 1181.14 \u00b1 105.62 mL; r = 0.988; ICC, 0.9754\u20130.9931). Gray matter and regional lobe volumes were comparable, while the white matter volume was slightly larger with CS-MPRAGE. CNR of the gray\u2013white matter was significantly higher with CS-MPRAGE (left, 30.45 \u00b1 11.21 vs. 49.53 \u00b1 32.71; right, 30.73 \u00b1 11.97 vs. 46.89 \u00b1 30.40; p = 0.0001) while SNR were similar across key brain regions. Conclusions: CS-MPRAGE provides high-quality 3D images and reliable volume data with significantly reduced acquisition time and comparable image quality.<\/jats:p>","DOI":"10.3390\/tomography12090121","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:49:34Z","timestamp":1787582974000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of Compressed Sensing Accelerated Magnetization Prepared Rapid Acquisition Gradient Echo for Fast and Reliable Brain Volume Measurement"],"prefix":"10.3390","volume":"12","author":[{"given":"Jung Bin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Shin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leehi","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-7832","authenticated-orcid":false,"given":"Younghee","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Republic of Korea"},{"name":"Biomedical Research Institute, Chung-Ang University Hospital, Seoul 06973, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20190365","DOI":"10.1259\/bjr.20190365","article-title":"The quantitative neuroradiology initiative framework: Application to dementia","volume":"92","author":"Goodkin","year":"2019","journal-title":"Br. 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