{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:17:59Z","timestamp":1788153479748,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abdus Salam International Centre for Theoretical Physics in Trieste","award":["42100INF01"],"award-info":[{"award-number":["42100INF01"]}]},{"name":"Abdus Salam International Centre for Theoretical Physics in Trieste","award":["34000IAE02"],"award-info":[{"award-number":["34000IAE02"]}]},{"award":["42100INF01"],"award-info":[{"award-number":["42100INF01"]}],"id":[{"id":"https:\/\/ror.org\/009gyvm78","id-type":"ROR","asserted-by":"publisher"}]},{"award":["34000IAE02"],"award-info":[{"award-number":["34000IAE02"]}],"id":[{"id":"https:\/\/ror.org\/009gyvm78","id-type":"ROR","asserted-by":"publisher"}]},{"name":"National Institute of Nuclear Physics in Trieste","award":["4210000000"],"award-info":[{"award-number":["4210000000"]}]},{"DOI":"10.13039\/501100004493","name":"International Atomic Energy Agency","doi-asserted-by":"crossref","award":["45300IAE02"],"award-info":[{"award-number":["45300IAE02"]}],"id":[{"id":"10.13039\/501100004493","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008206","name":"Australian Synchrotron","doi-asserted-by":"publisher","award":["AS232\/IMBL\/19932"],"award-info":[{"award-number":["AS232\/IMBL\/19932"]}],"id":[{"id":"10.13039\/100008206","id-type":"DOI","asserted-by":"publisher"}]},{"award":["AS232\/IMBL\/19932"],"award-info":[{"award-number":["AS232\/IMBL\/19932"]}],"id":[{"id":"https:\/\/ror.org\/03vk18a84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Background\/Objective: Radiomics offers a powerful, non-invasive approach for extracting quantitative features to predict lesion phenotypes. This study performs a radiomic characterization of breast tissue using synchrotron radiation breast computed tomography (SR-bCT). Method: Four mastectomy samples were imaged at the Australian Synchrotron (ANSTO) using five energies (25, 32, 35, 40, and 60 keV). From 10 slices per energy for each sample, 1546 regions of interest (ROIs) were extracted across four tissue subtypes: fatty, glandular, fibrous, and microcalcified. Using Pyradiomics, 93 features were initially calculated and then reduced to 34, eliminating highly correlated variables to reduce redundancies. Seven linear regression models and a discriminant analysis evaluated subtype tissue separation and radiomic characterization across individuals and combined samples and energies with a good fit (0.81 \u2264 R \u2264 0.98). Results: The study identified six possible robust exploratory candidate features independent of sample variability and energy levels, whose mean values are significantly different among the four tissue subtypes (clusters, p &lt; 0.001). The selected candidate features were 90th Percentile, Kurtosis, Skewness, GLCM IDM, GLDM LDE, and NGTDM Coarseness. These metrics successfully differentiated all tissue pairs (microcalcifications\/fat, microcalcifications\/gland, microcalcifications\/fiber, fat\/gland, fat\/fiber and gland\/fiber), with p &lt; 0.05 inside the most general regression model and p &lt; 0.0001 with the linear discriminant separation in clusters. Conclusions: Findings indicate that some first-order and second-order texture metrics reflecting global dependencies remain stable across experimental conditions. Conversely, fine-texture metrics are highly sensitive to sample energy changes, limiting their generalizability. These results align with successful biomarkers in mammography and validate the potential of radiomics in SR-bCT characterization.<\/jats:p>","DOI":"10.3390\/tomography12090124","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:08:58Z","timestamp":1788142138000},"page":"124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiomic Characterization of Breast Tissue from Breast CT Images Obtained with Synchrotron Beams"],"prefix":"10.3390","volume":"12","author":[{"given":"Marlen","family":"Perez-Diaz","sequence":"first","affiliation":[{"name":"Division of Trieste, National Institute for Nuclear Physics (INFN), 34149 Trieste, Italy"},{"name":"TRIL Program, The Abdus Salam International Centre for Theoretical Physics (ICTP), 34151 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Ariel","family":"Fernandez-Pirez","sequence":"additional","affiliation":[{"name":"Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City 07360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-8191","authenticated-orcid":false,"given":"Luca","family":"Brombal","sequence":"additional","affiliation":[{"name":"Division of Trieste, National Institute for Nuclear Physics (INFN), 34149 Trieste, Italy"},{"name":"Department of Physics, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Renata","family":"Longo","sequence":"additional","affiliation":[{"name":"Division of Trieste, National Institute for Nuclear Physics (INFN), 34149 Trieste, Italy"},{"name":"Department of Physics, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Anton","family":"Maksimenko","sequence":"additional","affiliation":[{"name":"Australian Synchrotron, ANSTO, Clayton, VIC 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-4686","authenticated-orcid":false,"given":"Caroline Kachana","family":"Pwamang","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Trieste, 34127 Trieste, Italy"},{"name":"Department of Medical Physics, University of Ghana, Legon, Accra G4-489-4642, Ghana"},{"name":"Nuclear Regulatory Authority, Accra GE-291-5715, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stevan","family":"Vrbaski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21137 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-1851","authenticated-orcid":false,"given":"Luigi","family":"Rigon","sequence":"additional","affiliation":[{"name":"Division of Trieste, National Institute for Nuclear Physics (INFN), 34149 Trieste, Italy"},{"name":"Department of Physics, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101719","DOI":"10.1016\/j.xcrm.2024.101719","article-title":"Radiomics in breast cancer: Current advances and future directions","volume":"5","author":"Qi","year":"2024","journal-title":"Cell Rep. 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