{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:54:38Z","timestamp":1783338878465,"version":"3.54.6"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Background: The present study examined the relationships among macular microvasculature, retinal structure, and epiretinal membrane (ERM) and explored the utility of optical coherence tomography (OCT) angiography (OCTA) in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. A total of 154 eyes with ERM and 122 normal (control) eyes were analyzed. Only one eye of each participant was randomly selected for posterior segment imaging. Each patient underwent OCT and OCTA. Images were analyzed with AngioTool 0.6. Results: Foveal avascular zone was significantly smaller in the ERM group (p = 0.044). Average retinal thickness and foveal thickness were significantly higher in the ERM group (both p = 0.001). Moreover, 64 (41.5%) patients exhibited no metamorphopsia, while 46 (29.8%) and 44 (28.7%) patients exhibited moderate and extensive metamorphopsias, respectively. Meanwhile, FAZ was negatively correlated with central retinal thickness in the ERM group. The vessel area (p = 0.0017) and vessel percentage area (p = 0.044) were significantly greater in the ERM group. Conclusions: Changes observed in the superficial plexus in OCTA are related to the severity of metamorphopsia and can be further evaluated to support decision making regarding the surgical management of idiopathic ERM.<\/jats:p>","DOI":"10.3390\/tomography8010016","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:10:36Z","timestamp":1641978636000},"page":"189-199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Idiopathic Epiretinal Membrane: Microvasculature Analysis with Optical Coherence Tomography and Optical Coherence Tomography Angiography"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-0219","authenticated-orcid":false,"given":"Klaudia","family":"Ulfik-Dembska","sequence":"first","affiliation":[{"name":"Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-566 Katowice, Poland"},{"name":"District Railway Hospital, Panewnicka 65, 40-760 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-8880","authenticated-orcid":false,"given":"S\u0142awomir","family":"Teper","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-566 Katowice, Poland"},{"name":"District Railway Hospital, Panewnicka 65, 40-760 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-6748","authenticated-orcid":false,"given":"Micha\u0142","family":"Dembski","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-566 Katowice, Poland"},{"name":"District Railway Hospital, Panewnicka 65, 40-760 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-3486","authenticated-orcid":false,"given":"Anna","family":"Nowi\u0144ska","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-566 Katowice, Poland"},{"name":"District Railway Hospital, Panewnicka 65, 40-760 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Wyl\u0119ga\u0142a","sequence":"additional","affiliation":[{"name":"Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Poniatowskiego 15, 40-566 Katowice, Poland"},{"name":"District Railway Hospital, Panewnicka 65, 40-760 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jfo.2016.12.001","article-title":"Prognostic factors of epiretinal membranes: A systematic review","volume":"40","author":"Miguel","year":"2017","journal-title":"J. Fran\u00e7ais d\u2019Ophtalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/IAE.0000000000002547","article-title":"Important Role of Epiretinal Membrane in Tractional Vitreomaculopathies","volume":"39","author":"Johnson","year":"2019","journal-title":"Retina"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0161-6420(02)01443-4","article-title":"Five-year cumulative incidence and progression of epiretinal membranes","volume":"110","author":"Guzowski","year":"2003","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1097\/IAE.0000000000000349","article-title":"Idiopathic Epiretinal Membrane","volume":"34","author":"Bu","year":"2014","journal-title":"Retina"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.4103\/ijo.IJO_650_18","article-title":"Epiretinal membrane profile on spectral domain optical coherence tomography in patients with uveitis","volume":"67","author":"Kumar","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_6","first-page":"3409327","article-title":"Optical Coherence Tomography: Basic Concepts and Applications in Neuroscience Research","volume":"2017","author":"Mokbul","year":"2017","journal-title":"J. Med. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/bjophthalmol-2016-309389","article-title":"Optical coherence tomography angiography: An overview of the technology and an assessment of applications for clinical research","volume":"101","author":"Koustenis","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/eye.2015.180","article-title":"Optical coherence tomographic angiography shows reduced deep capillary flow in paracentral acute middle maculopathy","volume":"29","author":"Dansingani","year":"2015","journal-title":"Eye"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/bjophthalmol-2016-309094","article-title":"Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography","volume":"101","author":"Malihi","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zudaire, E., Gambardella, L., Kurcz, C., and Vermeren, S. (2011). A Computational Tool for Quantitative Analysis of Vascular Networks. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027385"},{"key":"ref_11","first-page":"89","article-title":"OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling","volume":"5","author":"Liu","year":"2017","journal-title":"EC Ophthalmol."},{"key":"ref_12","first-page":"81","article-title":"Decrease of the foveal avascular zone area after internal limiting membrane peeling: Single case study","volume":"10","author":"Kumagai","year":"2017","journal-title":"Int. Med. Case Rep. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1097\/IAE.0000000000001778","article-title":"Foveal Avascular Zone Area after Internal Limiting Membrane Peeling for Epiretinal Membrane and Macular Hole Compared with That of Fellow Eyes and Healthy Controls","volume":"38","author":"Kumagai","year":"2018","journal-title":"Retina"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/IAE.0000000000001972","article-title":"Foveal avascular zone area analysis using optical coherence tomography angiography before and after idiopathic epiretinal membrane surgery","volume":"39","author":"Kitagawa","year":"2019","journal-title":"Retina"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Okawa, Y., Maruko, I., Kawai, M., Hasegawa, T., Arakawa, H., and Iida, T. (2019). Foveal structure and vasculature in eyes with idiopathic epiretinal membrane. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214881"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1097\/IAE.0000000000000847","article-title":"Correlation of foveal avascular zone size with foveal morphology in normal eyes using optical coherence tomography angiography","volume":"35","author":"Samara","year":"2015","journal-title":"Retina"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3928\/23258160-20190503-06","article-title":"Foveal Avascular Zone Distortion in Epiretinal Membrane by Optical Coherence Tomography Angiography","volume":"50","author":"Muftuoglu","year":"2019","journal-title":"Ophthalmic Surg. Lasers Imaging Retin."},{"key":"ref_18","first-page":"1711","article-title":"Superficial foveal avascular zone area changes before and after idiopathic epiretinal membrane surgery","volume":"11","author":"Yoon","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17092","DOI":"10.1038\/s41598-020-74190-x","article-title":"Association of foveal avascular zone with the metamorphopsia in epiretinal membrane","volume":"10","author":"Shiihara","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00417-019-04245-x","article-title":"Relationship between the morphology of the foveal avascular zone and the degree of aniseikonia before and after vitrectomy in patients with unilateral epiretinal membrane","volume":"257","author":"Hirata","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Munk, M.R., Giannakaki-Zimmermann, H., Berger, L., Huf, W., Ebneter, A., Wolf, S., and Zinkernagel, M.S. (2017). OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177059"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/IAE.0000000000001400","article-title":"Semiautomated quantitative approach to characterize treatment response in neovascular age-related macular degeneration","volume":"37","author":"Roberts","year":"2017","journal-title":"Retina"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.2147\/OPTH.S179634","article-title":"Morphometrical evaluation of the choriocapillaris imaged by swept-source optical coherence tomography angiography","volume":"12","author":"Sugano","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1177\/1120672120925790","article-title":"Optical coherence tomography angiography markers associated with treatment response in neovascular age-related macular degeneration","volume":"31","author":"Zeydanli","year":"2021","journal-title":"Eur. J. Ophthalmol."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/1\/16\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:28:37Z","timestamp":1760365717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/1\/16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["tomography8010016"],"URL":"https:\/\/doi.org\/10.3390\/tomography8010016","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]}}}