{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:14:10Z","timestamp":1760890450466,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Placement of image-guided tunneled and non-tunneled large-bore central venous catheters (CVCs) are common procedures in interventional radiology. Although leukopenia and\/or thrombocytopenia are common at the time of placement, the roles these factors may have in subsequent catheter-related infection have yet to be investigated. A single-institution retrospective review was performed in patients who underwent CVC placement in interventional radiology between 11\/2018\u20136\/2019. The electronic medical record was used to obtain demographics, procedure details, pre-placement laboratory values, and the subsequent 90-day follow-up. A total of 178 tunneled and non-tunneled CVCs met inclusion criteria during this time period. White blood cell (WBC) and platelet counts were found to be significant risk factors for subsequent infection. Administration of pre-procedure antibiotics was not found to be a significant factor for subsequent infection (p = 0.075). Leukopenia and thrombocytopenia at the time of CVC placement are both risk factors of line infection for tunneled large-bore CVCs. This should lead to the consideration of using a non-tunneled CVC when clinically feasible, or the delayed placement of these catheters until counts recover.<\/jats:p>","DOI":"10.3390\/tomography8020052","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T21:31:47Z","timestamp":1646170307000},"page":"627-634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre-Procedure Thrombocytopenia and Leukopenia Association with Risk for Infection in Image-Guided Tunneled Central Venous Catheter Placement"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-1470","authenticated-orcid":false,"given":"Abigail","family":"Luman","sequence":"first","affiliation":[{"name":"School of Medicine, University of Utah, Salt Lake City, UT 84132, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith B.","family":"Quencer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-2029","authenticated-orcid":false,"given":"Claire","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4065\/81.9.1159","article-title":"The risk of bloodstream infection in adults with different intravascular devices: A systematic review of 200 published prospective studies","volume":"81","author":"Maki","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s15010-014-0689-y","article-title":"Attributable mortality of central line associated bloodstream infection: Systematic review and meta-analysis","volume":"43","author":"Ziegler","year":"2015","journal-title":"Infection"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: Working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.2215\/CJN.00950208","article-title":"Aspects of immune dysfunction in end-stage renal disease","volume":"3","author":"Kato","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1177\/000313480707301035","article-title":"Complications of implanted central venous catheters in neutropenic children","volume":"73","author":"Elihu","year":"2007","journal-title":"Am. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jvir.2016.10.007","article-title":"Severe Neutropenia at the Time of Implantable Subcutaneous Chest Port Insertion Is Not a Risk Factor for Port Removal at a Tertiary Pediatric Center","volume":"28","author":"Hoss","year":"2017","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jvir.2013.11.038","article-title":"Clinical predictors of port infections within the first 30 days of placement","volume":"25","author":"Bamba","year":"2014","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.jvir.2020.05.018","article-title":"Risk Factors for Early Port Infections in Adult Oncologic Patients","volume":"31","author":"Skummer","year":"2020","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.5301\/jva.5000586","article-title":"The risk of bleeding with tunneled dialysis catheter placement","volume":"17","author":"Beathard","year":"2016","journal-title":"J. Vasc. Access."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1148\/radiology.204.1.9205228","article-title":"Patients with thrombocytopenia: Outcome of radiologic placement of central venous access devices","volume":"204","author":"Ray","year":"1997","journal-title":"Radiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.jvir.2019.04.017","article-title":"Society of Interventional Radiology Consensus Guidelines for the Periprocedural Management of Thrombotic and Bleeding Risk in Patients Undergoing Percutaneous Image-Guided Interventions-Part II: Recommendations: Endorsed by the Canadian Association for Interventional Radiology and the Cardiovascular and Interventional Radiological Society of Europe","volume":"30","author":"Patel","year":"2019","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/trf.14248","article-title":"Central venous catheter placement in coagulopathic patients: Risk factors and incidence of bleeding complications","volume":"57","author":"Biemond","year":"2017","journal-title":"Transfusion"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/vox.12498","article-title":"The practice of platelet transfusion prior to central venous catheterization in presence of coagulopathy: A national survey among clinicians","volume":"112","author":"Peters","year":"2017","journal-title":"Vox Sang."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jacr.2013.02.002","article-title":"Central venous access: Evolving roles of radiology and other specialties nationally over two decades","volume":"10","author":"Duszak","year":"2013","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00277-020-04286-x","article-title":"Central venous catheter-related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"100","author":"Boll","year":"2021","journal-title":"Ann. Hematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2019.12.001","article-title":"KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update","volume":"75","author":"Lok","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1055\/s-0036-1572547","article-title":"Update on Insertion and Complications of Central Venous Catheters for Hemodialysis","volume":"33","author":"Bream","year":"2016","journal-title":"Semin. Intervent. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S1072-7515(98)00096-9","article-title":"Risk factors for early infection of central venous catheters in pediatric patients","volume":"186","author":"Shaul","year":"1998","journal-title":"J. Am. Coll. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/annonc\/mds468","article-title":"Predictors of bloodstream infection associated with permanently implantable venous port in solid cancer patients","volume":"24","author":"Chen","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.3389\/fimmu.2020.01962","article-title":"Crosstalk between Platelets and Microbial Pathogens","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s00277-018-3367-9","article-title":"Low platelet count as risk factor for infections in patients with primary immune thrombocytopenia: A retrospective evaluation","volume":"97","author":"Qu","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1182\/blood-2010-10-312819","article-title":"Long-term clinical outcomes of patients with primary chronic immune thrombocytopenia: A Danish population-based cohort study","volume":"117","author":"Norgaard","year":"2011","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0002-9610(00)00552-3","article-title":"Central venous catheter placement in patients with disorders of hemostasis","volume":"180","author":"Mumtaz","year":"2000","journal-title":"Am. J. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.jvir.2018.06.007","article-title":"Adult and Pediatric Antibiotic Prophylaxis during Vascular and IR Procedures: A Society of Interventional Radiology Practice Parameter Update Endorsed by the Cardiovascular and Interventional Radiological Society of Europe and the Canadian Association for Interventional Radiology","volume":"29","author":"Chehab","year":"2018","journal-title":"J. Vasc. Interv. Radiol."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/2\/52\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:30:19Z","timestamp":1760135419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/2\/52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["tomography8020052"],"URL":"https:\/\/doi.org\/10.3390\/tomography8020052","relation":{},"ISSN":["2379-139X"],"issn-type":[{"type":"electronic","value":"2379-139X"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}