{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:32:02Z","timestamp":1794004322207,"version":"4.8.0"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["U01 CA172027"],"award-info":[{"award-number":["U01 CA172027"]}]},{"name":"NIH","award":["U01 EB028145"],"award-info":[{"award-number":["U01 EB028145"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Glioblastoma (GBM) is highly aggressive and has a poor prognosis. Belinostat is a histone deacetylase inhibitor with blood\u2013brain barrier permeability, anti-GBM activity, and the potential to enhance chemoradiation. The purpose of this clinical trial was to assess the efficacy of combining belinostat with standard-of-care therapy. Thirteen patients were enrolled in each of control and belinostat cohorts. The belinostat cohort was given a belinostat regimen (500\u2013750 mg\/m2 1\u00d7\/day \u00d7 5 days) every three weeks (weeks 0, 3, and 6 of RT). All patients received temozolomide and radiation therapy (RT). RT margins of 5\u201310 mm were added to generate clinical tumor volumes and 3 mm added to create planning target volumes. Median overall survival (OS) was 15.8 months for the control cohort and 18.5 months for the belinostat cohort (p = 0.53). The recurrence volumes (rGTVs) for the control cohort occurred in areas that received higher radiation doses than that in the belinostat cohort. For those belinostat patients who experienced out-of-field recurrence, tumors were detectable by spectroscopic MRI before RT. Recurrence analysis suggests better in-field control with belinostat. This study highlights the potential of belinostat as a synergistic therapeutic agent for GBM. It may be particularly beneficial to combine this radio-sensitizing effect with spectroscopic MRI-guided RT.<\/jats:p>","DOI":"10.3390\/tomography8020057","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T20:36:30Z","timestamp":1646339790000},"page":"688-700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Final Report on Clinical Outcomes and Tumor Recurrence Patterns of a Pilot Study Assessing Efficacy of Belinostat (PXD-101) with Chemoradiation for Newly Diagnosed Glioblastoma"],"prefix":"10.3390","volume":"8","author":[{"given":"Karen","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"},{"name":"Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-4700","authenticated-orcid":false,"given":"Vicki","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"},{"name":"Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-3726","authenticated-orcid":false,"given":"Saumya S.","family":"Gurbani","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"},{"name":"Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Scott","family":"Cordova","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Schreibmann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-1747","authenticated-orcid":false,"given":"Brent D.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA"},{"name":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-1397","authenticated-orcid":false,"given":"Soma","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo D.","family":"Voloschin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Holdhoff","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Kleinberg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Olson","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"},{"name":"Department of Neurosurgery, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Kuo G.","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"},{"name":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsuk","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, GA 30322, USA"},{"name":"Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA"},{"name":"Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA"},{"name":"Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical 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