{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:09:25Z","timestamp":1773018565588,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:00:00Z","timestamp":1648944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Purpose: The aim of this study was to evaluate the role of Pi10 in patients with fibrotic interstitial lung abnormality (fibrotic ILA) in a chest CT, according to cumulative cigarette smoking. Methods: We retrospectively assessed 54 fibrotic ILA patients and 18 healthy non-smokers (control) who underwent non-enhanced CT and pulmonary function tests. We quantitatively analyzed airway changes (the inner luminal area, airway inner parameter, airway wall thickness, Pi10, skewness, and kurtosis) in the chest CT of fibrotic ILA patients, and the fibrotic ILA patients were categorized into groups based on pack-years: light, moderate, heavy. Airway change data and pulmonary function tests among the three groups of fibrotic ILA patients were compared with those of the control group by one-way ANOVA. Results: Mean skewness (2.58 \u00b1 0.36) and kurtosis (7.64 \u00b1 2.36) in the control group were significantly different from those of the fibrotic ILA patients (1.89 \u00b1 0.37 and 3.62 \u00b1 1.70, respectively, p &lt; 0.001). In fibrotic ILA group, only heavy smokers had significantly increased Pi10 (mean increase 0.04, p = 0.013), increased airway wall thickness of the segmental bronchi (mean increase 0.06 mm, p = 0.005), and decreased lung diffusing capacity for carbon monoxide (p = 0.023). Conclusion: Pi10, as a biomaker of quantitative CT in fibrotic ILA patients, can reveal that smoking affects airway remodeling.<\/jats:p>","DOI":"10.3390\/tomography8020082","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T05:50:43Z","timestamp":1649051443000},"page":"1024-1032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative Assessment of Airway Changes in Fibrotic Interstitial Lung Abnormality Patients by Chest CT According to Cumulative Cigarette Smoking"],"prefix":"10.3390","volume":"8","author":[{"given":"Yuan Zhe","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology, Jeonbuk National University Medical School, Jeonju 54896, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-554X","authenticated-orcid":false,"given":"Gong Yong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeonbuk National University Medical School, Jeonju 54896, Korea"},{"name":"Research Institute of Clinical Medicine, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Institute of Medical Science, Jeonju 54970, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kum Ju","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeonbuk National University Medical School, Jeonju 54896, Korea"},{"name":"Research Institute of Clinical Medicine, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Institute of Medical Science, Jeonju 54970, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Min","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeonbuk National University Medical School, Jeonju 54896, Korea"},{"name":"Research Institute of Clinical Medicine, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Institute of Medical Science, Jeonju 54970, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1007\/s00330-021-08378-8","article-title":"Radiologic-pathologic correlation of interstitial lung abnormalities and predictors for progression and survival","volume":"32","author":"Chae","year":"2022","journal-title":"Eur. 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