{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:14:57Z","timestamp":1791645297196,"version":"4.3.4"},"reference-count":22,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>(1) Background: Silicone oil (SO) can be used as an endotamponade during vitreoretinal surgery for retinal detachment. There is emerging evidence that SO filling of the vitreous cavity and its removal may impact macular perfusion. So far, studies have not focused on choroidal sublayer perfusion, yet. (2) Methods: Optical coherence tomography angiography was applied in 19 patients with SO endotamponade before and four weeks after removal of SO. (3) Results: Perfusion of choriocapillaris increased significantly after SO removal, while perfusion of Haller\u2019s and Sattler\u2019s layer decreased significantly. (4) Conclusions: Removal of SO impacts choroidal perfusion and leads to a perfusion shift within choroidal sublayers. This study underlines that it is worth to conduct larger prospective studies that evaluate the choroidal perfusion and its functional implications in more detail.<\/jats:p>","DOI":"10.3390\/tomography8040146","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T21:15:52Z","timestamp":1657142152000},"page":"1735-1741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Silicone Oil Removal on Macular Perfusion"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-2963","authenticated-orcid":false,"given":"Michelle","family":"Prasuhn","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Hospital Schleswig-Holstein, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-0607","authenticated-orcid":false,"given":"Felix","family":"Rommel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Schleswig-Holstein, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Mohi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Schleswig-Holstein, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Grisanti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Schleswig-Holstein, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdy","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Schleswig-Holstein, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1097\/IAE.0000000000001553","article-title":"Risk of silicone oil as vitreous tamponade in pars plana vitrectomy: A systematic review and meta-analysis","volume":"37","author":"Feng","year":"2017","journal-title":"Retina"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s10792-020-01418-0","article-title":"Inner retinal toxicity due to silicone oil: A case series and review of the literature","volume":"40","author":"Pichi","year":"2020","journal-title":"Int. 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Vitr."},{"key":"ref_6","first-page":"729","article-title":"Effect of silicone oil on macular capillary vessel density and thickness","volume":"19","author":"Xiang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_7","first-page":"65","article-title":"Retinal hemodynamics after pars plana vitrectomy with silicone oil tamponade","volume":"3","author":"Effert","year":"1994","journal-title":"Ger. J. Ophthalmol."},{"key":"ref_8","first-page":"146","article-title":"Macular microcirculation blood flow after pars plana vitrectomy with silicone oil tamponade","volume":"113","author":"Kobylarz","year":"2011","journal-title":"Klin. Ocz."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.003","article-title":"Optical coherence tomography angiography","volume":"64","author":"Spaide","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.joco.2018.02.001","article-title":"Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults","volume":"30","author":"Rommel","year":"2018","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40942-020-00227-y","article-title":"Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography","volume":"6","author":"Rommel","year":"2020","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40942-019-0162-2","article-title":"Mapping diurnal variations in choroidal sublayer perfusion in patients with idiopathic epiretinal membrane: An optical coherence tomography angiography study","volume":"5","author":"Rommel","year":"2019","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"Threshold selection method from gray-level histograms","volume":"SMC-9","author":"Otsu","year":"1979","journal-title":"IEEE Trans. Syst. Man. Cybern."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.18240\/ijo.2021.06.13","article-title":"A decrease in macular microvascular perfusion after retinal detachment repair with silicone oil","volume":"14","author":"Fang","year":"2021","journal-title":"Int. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1007\/s10792-020-01516-z","article-title":"Optical coherence tomography angiography changes in macula-off rhegmatogenous retinal detachments repaired with silicone oil","volume":"40","author":"Roohipoor","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1038\/s41598-020-59504-3","article-title":"Foveal microvascular structures in eyes with silicone oil tamponade for rhegmatogenous retinal detachment: A swept-source optical coherence tomography angiography study","volume":"10","author":"Lee","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s10792-021-02196-z","article-title":"Longitudinal evaluation of retinal thickness and OCTA parameters before and following silicone oil removal in eyes with macula-on and macula-off retinal detachments","volume":"42","author":"Bayraktar","year":"2022","journal-title":"Int. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10792-018-0993-0","article-title":"Subfoveal choroidal thickness change following pars plana vitrectomy with silicone oil endotamponade for rhegmatogenous retinal detachment","volume":"39","author":"Mirza","year":"2019","journal-title":"Int. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.preteyeres.2009.12.002","article-title":"The multifunctional choroid","volume":"29","author":"Nickla","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41433-020-01217-y","article-title":"Evaluation of the inner choroid using OCT angiography","volume":"35","author":"Corvi","year":"2021","journal-title":"Eye"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1038\/s41598-019-39839-2","article-title":"Correlation between preoperative factors and final visual acuity after successful rhegmatogenous retinal reattachment","volume":"9","author":"Hirata","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_22","first-page":"83","article-title":"Final anatomic and visual outcomes appear independent of duration of silicone oil intraocular tamponade in complex retinal detachment surgery","volume":"11","author":"Rhatigan","year":"2018","journal-title":"Int. J. Ophthalmol."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/4\/146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:43:15Z","timestamp":1760139795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/4\/146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["tomography8040146"],"URL":"https:\/\/doi.org\/10.3390\/tomography8040146","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]}}}