{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:59:12Z","timestamp":1791907152653,"version":"4.3.4"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Rationale and Objective: Thoracic CT angiography (CTA) for ascending aortic dissection, a life-threatening emergency, is performed routinely without Electrocardiographic (ECG) gating, therefore allowing the apparition of a pulsation artefact. We aimed to evaluate and compare the diagnostic performance, the inter and intra-reporter agreement of ECG gated CTA and non-ECG gated CTA for detecting ascending aortic dissection, considering their training level. Our hypothesis is that ECG gated CTA has superior diagnostic accuracy for ascending aortic dissection compared to non-gated CTA. Materials and Methods: We collected data using 24 questions survey using clinically validated CT examinations. Sixty-six respondents (medical students, radiology residents, and consultants) blinded to the actual diagnosis independently evaluated the images pertaining to the presence of ascending aortic dissection. The reference standard was represented by clinical and imaging diagnosis. Inter-rater and inter-group concordance was evaluated; the agreement with reference tests was calculated and assessed as a function of reporters\u2019 training level. Results: Reporters\u2019 ascending aortic dissection assessment showed a better correlation with the reference standard in the ECG gated CTA. The inter-rater correlation was higher in the ECG gated CTA compared to non-ECG gated CTA. Observers\u2019 confidence for diagnosing ascending aortic dissection was higher in the ECG gated CTA. Statistically significant differences (p &lt; 0.05) were found between different training levels when assessing non-ECG gated examinations. Conclusions: ECG gated CTA shows a higher diagnostic performance for ascending aortic dissection than non-ECG gated CTA, regardless of the reporters\u2019 training level.<\/jats:p>","DOI":"10.3390\/tomography8050201","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T01:23:16Z","timestamp":1664414596000},"page":"2426-2434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparing the Diagnostic Performance of ECG Gated versus Non-Gated CT Angiography in Ascending Aortic Dissection: A GRRAS Study"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1259-7305","authenticated-orcid":false,"given":"Razvan G.","family":"Budeanu","sequence":"first","affiliation":[{"name":"Emergency County Hospital T\u00e2rgu Mure\u0219, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Broemmer","sequence":"additional","affiliation":[{"name":"ME1 Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria R.","family":"Budeanu","sequence":"additional","affiliation":[{"name":"Emergency County Hospital T\u00e2rgu Mure\u0219, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-9780","authenticated-orcid":false,"given":"Marian","family":"Pop","sequence":"additional","affiliation":[{"name":"ME1 Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania"},{"name":"Radiology and Medical Imaging Department, Emergency Institute for Cardiovascular Disease and Heart Transplant of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s003300100937","article-title":"Coronary Artery Aneurysm and Type-A Aortic Dissection Demonstrated by Retrospectively ECG-Gated Multislice Spiral CT","volume":"12","author":"Fallenberg","year":"2001","journal-title":"Eur. Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1148\/radiol.2383041528","article-title":"Suspected Aortic Dissection and Other Aortic Disorders: Multi\u2013Detector Row CT in 373 Cases in the Emergency Setting","volume":"238","author":"Hayter","year":"2006","journal-title":"Radiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.semtcvs.2008.11.011","article-title":"Acute Aortic Syndromes: New Insights from Electrocardiographically Gated Computed Tomography","volume":"20","author":"Fleischmann","year":"2008","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00004728-198603000-00008","article-title":"Computed Tomography of Thoracic Aortic Dissection","volume":"10","author":"Vasile","year":"1986","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2214\/ajr.136.1.13","article-title":"CT Findings in Thoracic Aortic Dissection","volume":"136","author":"Heiberg","year":"1981","journal-title":"Am. J. Roentgenol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1148\/radiology.136.1.7384486","article-title":"Evaluation of Dissections and Aneurysms of the Thoracic Aorta by Conventional and Dynamic CT Scanning","volume":"136","author":"Godwin","year":"1980","journal-title":"Radiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1148\/radiology.136.1.7384487","article-title":"Computed Tomography in Dissection of the Thoracic Aorta","volume":"136","author":"Gross","year":"1980","journal-title":"Radiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1148\/radiology.136.1.7384489","article-title":"Computed Tomography of Aortic Dissection","volume":"136","author":"Belloir","year":"1980","journal-title":"Radiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1148\/radiology.148.3.6878699","article-title":"Dissecting Aortic Aneurysms: Accuracy of Computed Tomographic Diagnosis","volume":"148","author":"Thorsen","year":"1983","journal-title":"Radiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2214\/ajr.157.3.1872227","article-title":"Motion Artifact Simulating Aortic Dissection on CT","volume":"157","author":"Burns","year":"1991","journal-title":"Am. J. Roentgenol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/00004728-198208000-00015","article-title":"Problems and Pitfalls in the Evaluation of Thoracic Aortic Dissection by Computed Tomography","volume":"6","author":"Godwin","year":"1982","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1053\/j.semvascsurg.2005.11.007","article-title":"Will Stent-Graft Repair Emerge as Treatment of Choice for Acute Type B Dissection?","volume":"19","author":"Dake","year":"2006","journal-title":"Semin. Vasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJM199905203402004","article-title":"Endovascular Stent\u2013Graft Placement for the Treatment of Acute Aortic Dissection","volume":"340","author":"Dake","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1148\/radiol.09090860","article-title":"Thoracic Aorta: Prospective Electrocardiographically Triggered CT Angiography with Dual-Source CT\u2014Feasibility, Image Quality, and Dose Reduction","volume":"255","author":"Blanke","year":"2010","journal-title":"Radiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2214\/AJR.08.2158","article-title":"Prospective and Retrospective ECG Gating for Thoracic CT Angiography: A Comparative Study","volume":"193","author":"Wu","year":"2009","journal-title":"Am. J. Roentgenol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lee, J., Jeong, Y.J., Lee, G., Kim, C.W., Kim, J.Y., Lee, N.K., Lee, H.C., and Lee, J.W. (2022). Non-ECG-Gated High-Pitch CT Angiography versus Hybrid ECG-Gated CT Angiography for Aorta Using 512-Slice CT: Comparison of Image Quality and Radiation Dose. Acta. Radiol., 028418512210959.","DOI":"10.1177\/02841851221095925"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kim, T.J., Lee, K.H., Choe, Y.H., and Lee, K.S. (2021). Acute Aortic Diseases: Evaluation with Computed Tomography and Magnetic Resonance Imaging. Emergency Chest Radiology, Springer Singapore.","DOI":"10.1007\/978-981-33-4396-2_6"},{"key":"ref_18","unstructured":"Wong, Y., Ong, C., Liang, C., Tan, C., and Teo, L. (2021). Image Quality, Contrast Enhancement and Radiation Dose of ECG-Triggered versus Non-ECG-Triggered Imaging of the Aorta on a Single Source 256-Slice CT Scanner. Singapore Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13244-020-00855-w","article-title":"Imaging of the Aortic Root on High-Pitch Non-Gated and ECG-Gated CT: Awareness Is the Key!","volume":"11","author":"Nagpal","year":"2020","journal-title":"Insights Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00330-019-06357-8","article-title":"CT and MR Imaging Prior to Transcatheter Aortic Valve Implantation: Standardisation of Scanning Protocols, Measurements and Reporting\u2014a Consensus Document by the European Society of Cardiovascular Radiology (ESCR)","volume":"30","author":"Francone","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcct.2018.11.008","article-title":"Computed Tomography Imaging in the Context of Transcatheter Aortic Valve Implantation (TAVI) \/ Transcatheter Aortic Valve Replacement (TAVR): An Expert Consensus Document of the Society of Cardiovascular Computed Tomography","volume":"13","author":"Blanke","year":"2019","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jclinepi.2010.03.002","article-title":"Guidelines for Reporting Reliability and Agreement Studies (GRRAS) Were Proposed","volume":"64","author":"Kottner","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass Correlations: Uses in Assessing Rater Reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The Measurement of Observer Agreement for Categorical Data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/acp.2886","article-title":"Looking in the Same Manner but Seeing It Differently: Bottom-up and Expertise Effects in Radiology","volume":"26","author":"Kok","year":"2012","journal-title":"Appl. Cogn. Psychol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnhum.2019.00213","article-title":"Analysis of Perceptual Expertise in Radiology\u2013Current Knowledge and a New Perspective","volume":"13","author":"Waite","year":"2019","journal-title":"Front. Hum. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20150705","DOI":"10.1259\/bjr.20150705","article-title":"Recommendations for Accurate CT Diagnosis of Suspected Acute Aortic Syndrome (AAS)--on Behalf of the British Society of Cardiovascular Imaging (BSCI)\/British Society of Cardiovascular CT (BSCCT)","volume":"89","author":"Vardhanabhuti","year":"2016","journal-title":"Br. J. Radiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Pop, M. (2021). Cardiothoracic CTA in Infants Referred for Aortic Arch Evaluation-Retrospective Comparison of Iomeprol 350, Ioversol 350, Iopromide 370 and Iodixanol 320. Children, 8.","DOI":"10.3390\/children8110949"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Pop, R.-M., Tenenboum, A., and Pop, M. (2021). Secular Trends in Height, Body Mass and Mean Menarche Age in Romanian Children and Adolescents, 1936-2016. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18020490"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/europace\/euq135","article-title":"Comparison of Non-Gated vs. Electrocardiogram-Gated 64-Detector-Row Computed Tomography for Integrated Electroanatomic Mapping in Patients Undergoing Pulmonary Vein Isolation","volume":"12","author":"Wagner","year":"2010","journal-title":"Europace"},{"key":"ref_31","first-page":"28","article-title":"Coronary CT Angiography with Prospective ECG-Triggering: An Effective Alternative to Invasive Coronary Angiography","volume":"2","author":"Sun","year":"2012","journal-title":"Cardiovasc. Diagn. Ther."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/5\/201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:06Z","timestamp":1760143266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/5\/201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["tomography8050201"],"URL":"https:\/\/doi.org\/10.3390\/tomography8050201","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,28]]}}}