{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T10:44:52Z","timestamp":1773571492913,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfeicoamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>In the present study, we aimed to assess frontal ethmoidal cells by using segmentation 3D software to establish a possible correlation between volume variation and both gender and age, as well as a relationship with Keros classification. Helical computed tomography images were obtained from 71 patients for analysis, in which the agger nasi cell, supra agger cell, supra agger frontal cell, supra bulla frontal cell, supraorbital ethmoidal cell, supra bulla cell, and frontal septal cell were identified and segmented to obtain their volume. Significant differences in volume were found for age and gender regarding agger nasi cells (p-value = 0.017), supra agger cells (p-value &lt; 0.001), and frontal septal cells (p-value = 0.049). In the frontal septal cells, an increase of one year in age reduced the volume by 0.309, on average. According to Keros classification, the mean volumes were 10.07 and 25.64, respectively, for types II and III, both being greater than that of type I. Extracting volumetric data by using segmentation software in agger nasi cells, supra agger cells, and frontal septal cells may be useful for obtaining additional information related to age, in addition to possibly contributing to elucidating the anatomical variations in the region and an identification forensic tool.<\/jats:p>","DOI":"10.3390\/tomography8060233","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T03:58:16Z","timestamp":1669262296000},"page":"2796-2805","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Three-Dimensional Volumetric Analysis of Frontal Ethmoidal Cells and Evaluation of Influential Factors: A Helical Computed Tomography Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Ana L\u00facia Franco","family":"Ricardo","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Dentomaxillofacial Radiology and Imaging Laboratory, Department of Dentistry, Cruzeiro do Sul University (UNICSUL), S\u00e3o Paulo 01506-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Massahiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Dentomaxillofacial Radiology and Imaging Laboratory, Department of Dentistry, Cruzeiro do Sul University (UNICSUL), S\u00e3o Paulo 01506-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro Perez","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina Simioni","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-5862","authenticated-orcid":false,"given":"S\u00e9rgio L\u00facio Pereira de Castro","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, S\u00e3o Jos\u00e9 dos Campos School of Dentistry, S\u00e3o Paulo State University (UNESP), S\u00e3o Jos\u00e9 dos Campos 12245-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9521","authenticated-orcid":false,"given":"Paulo Henrique","family":"Braz-Silva","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo (USP), S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-0176","authenticated-orcid":false,"given":"Kaan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara University, 06560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-5417","authenticated-orcid":false,"given":"Andre Luiz Ferreira","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Dentomaxillofacial Radiology and Imaging Laboratory, Department of Dentistry, Cruzeiro do Sul University (UNICSUL), S\u00e3o Paulo 01506-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1017\/S0022215120002066","article-title":"Computed tomographic analysis of the prevalence of International Frontal Sinus Anatomy Classification cells and their association with frontal sinusitis","volume":"134","author":"Seth","year":"2020","journal-title":"J. Laryngol. Otol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/alr.22105","article-title":"Computed tomography analysis of frontal cell prevalence according to the International Frontal Sinus Anatomy Classification","volume":"8","author":"Choby","year":"2018","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_3","unstructured":"Cappello, Z.J., Minutello, K., and Dublin, A.B. (2022). Anatomy, Head and Neck, Nose Paranasal Sinuses, StatPearls."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"M, S., Bagewadi, A., Lagali-Jirge, V., S, L.K., Panwar, A., and Keluskar, V. (2022). Reliability of gender determination from paranasal sinuses and its application in forensic identification-a systematic review and meta-analysis. Forensic. Sci. Med. Pathol.","DOI":"10.1007\/s12024-022-00520-2"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3342\/ceo.2010.3.2.76","article-title":"Pneumatization Pattern of the Frontal Recess: Relationship of the Anterior-to-Posterior Length of Frontal Isthmus and\/or Frontal Recess with the Volume of Agger Nasi Cell","volume":"3","author":"Park","year":"2010","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1055\/s-0040-1713923","article-title":"The Frontal Sinus and Frontal Recess: Anatomical, Radiological and Surgical Concepts","volume":"24","author":"Dassi","year":"2020","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1179550619884946","DOI":"10.1177\/1179550619884946","article-title":"The Relationship Between the Width of the Frontal Recess and the Frontal Recess Cells in Japanese Patients","volume":"12","author":"Makihara","year":"2019","journal-title":"Clin. Med. Insights Ear. Nose Throat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/000348949510410s01","article-title":"Paranasal sinuses:anatomic terminology and nomenclature","volume":"167","author":"Stammberger","year":"1995","journal-title":"Ann Otol. Rhinol. Laryngol. Suppl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/alr.21738","article-title":"The International Frontal Sinus Anatomy Classification (IFAC) and Classification of the Extent of Endoscopic Frontal Sinus Surgery (EFSS)","volume":"6","author":"Wormald","year":"2016","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_10","first-page":"Doc07","article-title":"Frequency and volumetry of infraorbital ethmoid cells (Haller cells) on cone-beam computed tomograms (CBCT) of the mid-face","volume":"6","author":"Friedrich","year":"2017","journal-title":"GMS Interdiscip. Plast Reconstr. Surg. DGPW"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/S0100-39842008000300003","article-title":"Computed tomography assessment of the ethmoid roof: A relevant region at risk in endoscopic sinus surgery","volume":"41","author":"Souza","year":"2008","journal-title":"Radiol. Bras."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s12070-017-1229-8","article-title":"A Study of Clinical Significance of the Depth of Olfactory Fossa in Patients Undergoing Endoscopic Sinus Surgery","volume":"69","author":"V","year":"2017","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.archoralbio.2018.06.021","article-title":"Investigation on the relationship of dimensions of the maxillary sinus drainage system with the presence of sinusopathies: A cone beam computed tomography study","volume":"94","author":"Fuziy","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1055\/s-0042-1742327","article-title":"Anatomical Variations of the Sinonasal Area and Their Clinical Impact on Sinus Pathology: A Systematic Review","volume":"26","author":"Papadopoulou","year":"2022","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_15","first-page":"244","article-title":"Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis","volume":"32","author":"Fadda","year":"2012","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s12070-013-0678-y","article-title":"Sinonasal anatomical variations: Their relationship with chronic rhinosinusitis and effect on the severity of disease-a computerized tomography assisted anatomical and clinical study","volume":"66","author":"Kaygusuz","year":"2014","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_17","first-page":"8176260","article-title":"Morphology, Volume, and Density Characteristics of the Parotid Glands before and after Chemoradiation Therapy in Patients with Head and Neck Tumors","volume":"2020","author":"Nussi","year":"2020","journal-title":"Int. J. Dent."},{"key":"ref_18","first-page":"e12727","article-title":"Anatomical Variations of the Nasal Cavities and Paranasal Sinuses: A Systematic Review","volume":"13","author":"Papadopoulou","year":"2021","journal-title":"Cureus"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5935\/1808-8694.20130052","article-title":"Analysis of the Agger nasi cell and frontal sinus ostium sizes using computed tomography of the paranasal sinuses","volume":"79","author":"Angelico","year":"2013","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_20","first-page":"1555","article-title":"Anatomy and imaging study of a new upper-agger nasi pathway of frontal sinus surgery","volume":"28","author":"Liu","year":"2014","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aanat.2016.05.007","article-title":"Three-dimensional lateral pterygoid muscle volume: MRI analyses with insertion patterns correlation","volume":"208","author":"Melke","year":"2016","journal-title":"Ann Anat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00414-016-1384-6","article-title":"Age estimation based on pulp cavity\/chamber volume of 13 types of tooth from cone beam computed tomography images","volume":"130","author":"Ge","year":"2016","journal-title":"Int. J. Legal. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5604\/01.3001.0010.0132","article-title":"Correlation between the extent of pneumatization of Agger agger Nasi nasi cells and the anterior-to-posterior length of the frontal recess: A a computer-assisted anatomical study","volume":"71","author":"Altintas","year":"2017","journal-title":"Otolaryngol. Pol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4103\/ijri.IJRI_119_18","article-title":"Olfactory fossa depth: CT analysis of 1200 patients","volume":"28","author":"Babu","year":"2018","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Guven, M., Elden, H., Yaylaci, A., Guven, E.M., Kara, A., and Orha, A.T. (2021). Age-dependent differences of the depth of olfactory fossa in children. Braz J. Otorhinolaryngol.","DOI":"10.1016\/j.bjorl.2021.09.006"},{"key":"ref_26","first-page":"e22378","article-title":"Evaluation of the Keros Classification of Olfactory Fossa by CT Scan in Qassim Region","volume":"14","author":"Almushayti","year":"2022","journal-title":"Cureus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ijporl.2012.02.050","article-title":"Age-dependent differences of the anterior skull base","volume":"76","author":"Guldner","year":"2012","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1177\/0194599817696302","article-title":"Analysis of the Relationship between the Location of the Anterior Ethmoid Artery and Keros Classification","volume":"157","author":"Poteet","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/alr.22307","article-title":"Reliability of the supraorbital ethmoid cell vs Keros classification in predicting the course of the anterior ethmoid artery","volume":"9","author":"Li","year":"2019","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"687582","DOI":"10.1155\/2013\/687582","article-title":"The prevalence of frontal cells and their relation to frontal sinusitis: A radiological study of the frontal recess area","volume":"2013","author":"Eweiss","year":"2013","journal-title":"ISRN Otolaryngol."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/6\/233\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:39Z","timestamp":1760145939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/6\/233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["tomography8060233"],"URL":"https:\/\/doi.org\/10.3390\/tomography8060233","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}