{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:47:26Z","timestamp":1767844046227,"version":"3.49.0"},"reference-count":16,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601522"],"award-info":[{"award-number":["81601522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["QNRC2016749"],"award-info":[{"award-number":["QNRC2016749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GSWS2020013"],"award-info":[{"award-number":["GSWS2020013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SYS2019038"],"award-info":[{"award-number":["SYS2019038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GZK1202127"],"award-info":[{"award-number":["GZK1202127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021HYX023"],"award-info":[{"award-number":["2021HYX023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021HYX029"],"award-info":[{"award-number":["2021HYX029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["81601522"],"award-info":[{"award-number":["81601522"]}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["QNRC2016749"],"award-info":[{"award-number":["QNRC2016749"]}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["GSWS2020013"],"award-info":[{"award-number":["GSWS2020013"]}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["SYS2019038"],"award-info":[{"award-number":["SYS2019038"]}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["GZK1202127"],"award-info":[{"award-number":["GZK1202127"]}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["2021HYX023"],"award-info":[{"award-number":["2021HYX023"]}]},{"name":"Medical Youth Talent Project of Jiangsu Province","award":["2021HYX029"],"award-info":[{"award-number":["2021HYX029"]}]},{"name":"Gusu Health Talent Program","award":["81601522"],"award-info":[{"award-number":["81601522"]}]},{"name":"Gusu Health Talent Program","award":["QNRC2016749"],"award-info":[{"award-number":["QNRC2016749"]}]},{"name":"Gusu Health Talent Program","award":["GSWS2020013"],"award-info":[{"award-number":["GSWS2020013"]}]},{"name":"Gusu Health Talent Program","award":["SYS2019038"],"award-info":[{"award-number":["SYS2019038"]}]},{"name":"Gusu Health Talent Program","award":["GZK1202127"],"award-info":[{"award-number":["GZK1202127"]}]},{"name":"Gusu Health Talent Program","award":["2021HYX023"],"award-info":[{"award-number":["2021HYX023"]}]},{"name":"Gusu Health Talent Program","award":["2021HYX029"],"award-info":[{"award-number":["2021HYX029"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["81601522"],"award-info":[{"award-number":["81601522"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["QNRC2016749"],"award-info":[{"award-number":["QNRC2016749"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["GSWS2020013"],"award-info":[{"award-number":["GSWS2020013"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["SYS2019038"],"award-info":[{"award-number":["SYS2019038"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["GZK1202127"],"award-info":[{"award-number":["GZK1202127"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["2021HYX023"],"award-info":[{"award-number":["2021HYX023"]}]},{"name":"Suzhou People\u2019s Livelihood Science and Technology Project","award":["2021HYX029"],"award-info":[{"award-number":["2021HYX029"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["81601522"],"award-info":[{"award-number":["81601522"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["QNRC2016749"],"award-info":[{"award-number":["QNRC2016749"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["GSWS2020013"],"award-info":[{"award-number":["GSWS2020013"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["SYS2019038"],"award-info":[{"award-number":["SYS2019038"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["GZK1202127"],"award-info":[{"award-number":["GZK1202127"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["2021HYX023"],"award-info":[{"award-number":["2021HYX023"]}]},{"name":"Project of State Key Laboratory of Radiation Medicine and Protection, Soochow University","award":["2021HYX029"],"award-info":[{"award-number":["2021HYX029"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["81601522"],"award-info":[{"award-number":["81601522"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["QNRC2016749"],"award-info":[{"award-number":["QNRC2016749"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["GSWS2020013"],"award-info":[{"award-number":["GSWS2020013"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["SYS2019038"],"award-info":[{"award-number":["SYS2019038"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["GZK1202127"],"award-info":[{"award-number":["GZK1202127"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["2021HYX023"],"award-info":[{"award-number":["2021HYX023"]}]},{"name":"Open Foundation of Nuclear Medicine Laboratory of Mianyang Central Hospital","award":["2021HYX029"],"award-info":[{"award-number":["2021HYX029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Background Rosai-Dorfman disease (RDD), the massive lymphadenopathy characterized by the proliferation of sinus histiocytosis, is a relatively idiopathic benign disease with unknown etiology. We reported a rare case of thymic RDD detected by 18F-FDG PET\/CT. A 23-year-old man with right-sided chest pain underwent 18F-FDG PET\/CT scan, showing increased 18F-FDG uptake in an anterior mediastinal mass corresponding to a thymic lesion at an enhanced CT scan. The patient was referred to surgery with the clinical suspicion of thymic malignancy. The histological examination and immunohistochemical results confirmed RDD. Conclusions This was the first case report of RDD isolated to the thymus and initially presented with chest pain. Moreover, there was no characteristic painless neck lymphadenopathy at any stage of the disease course. Thus, for young patients with thymus mass, RDD should be considered a rare but possible diagnosis.<\/jats:p>","DOI":"10.3390\/tomography8060237","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T08:43:03Z","timestamp":1669624983000},"page":"2839-2843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Rare Case of Thymic Rosai-Dorfman Disease Mimicking Malignancy on 18F-FDG PET\/CT"],"prefix":"10.3390","volume":"8","author":[{"given":"Tongtong","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Changshu No. 2 People\u2019s Hospital, Suzhou 215501, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibiao","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-7721","authenticated-orcid":false,"given":"Shengming","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"},{"name":"NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, China"},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"ref_1","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity","volume":"87","author":"Rosai","year":"1969","journal-title":"Arch Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0140-6736(87)90518-6","article-title":"Histiocytosis syndromes in children","volume":"1","author":"Henter","year":"1987","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/jclinpath-2020-206733","article-title":"Rosai-Dorfman disease: An overview","volume":"73","author":"Schneider","year":"2020","journal-title":"J. Clin. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.47391\/JPMA.22-022","article-title":"Rosai-Dorman disease mimicking lymphoma on 18F-FDG PET\/CT","volume":"72","author":"Usmani","year":"2022","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_5","first-page":"19","article-title":"Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity","volume":"7","author":"Foucar","year":"1990","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/RLU.0000000000000267","article-title":"Rosai-Dorfman disease mimics lymphoma on FDG PET\/CT in a pediatric patient","volume":"39","author":"Liu","year":"2014","journal-title":"Clin. Nucl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.anndiagpath.2019.02.004","article-title":"A comprehensive assessment of cutaneous Rosai-Dorfman disease","volume":"40","author":"Ahmed","year":"2019","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1097\/RLU.0000000000003911","article-title":"FDG PET\/CT in Isolated Thoracic Vertebral Rosai-Dorfman Disease","volume":"47","author":"Zhao","year":"2022","journal-title":"Clin. Nucl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/RLU.0000000000002501","article-title":"An isolated osseous Rosai-Dorfman disease shown on FDG PET\/CT","volume":"44","author":"Zadeh","year":"2019","journal-title":"Clin. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lim, R., Wittram, C., Ferry, J.A., and Shepard, J.A. (2004). FDG PET of Rosai-Dorfman disease of the thymus. AJR Am. J. Roentgenol., 182.","DOI":"10.2214\/ajr.182.2.1820514"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","article-title":"Histiocyte Society. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages","volume":"127","author":"Emile","year":"2016","journal-title":"Blood"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Haghighat Jahromi, A., Goodman, A.M., and Hoh, C.K. (2021). Rosai-Dorfman-Destombes (RDD) disease presenting as palindromic rheumatism. BMC Med. Imaging, 21.","DOI":"10.1186\/s12880-021-00596-2"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mosheimer, B.A., Oppl, B., Zandieh, S., Fillitz, M., Keil, F., Klaushofer, K., Weiss, G., and Zwerina, J. (2017). Bone Involvement in Rosai-Dorfman Disease (RDD): A Case Report and Systematic Literature Review. Curr. Rheumatol. Rep., 19.","DOI":"10.1007\/s11926-017-0656-6"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/RLU.0000000000001705","article-title":"Spontaneous Recovery of Rosai-Dorfman Disease on FDG PET\/CT","volume":"42","author":"Xue","year":"2017","journal-title":"Clin. Nucl Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/RLU.0b013e31828731da","article-title":"18F-FDG PET\/CT imaging features of Rosai Dorfman disease: A rare cause of massive generalized lymphadenopathy","volume":"39","author":"Karunanithi","year":"2014","journal-title":"Clin. Nucl. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.athoracsur.2019.04.089","article-title":"Mediastinal Rosai-Dorfman Disease with Widespread Lesions: When Surgical Biopsy Is Needed","volume":"109","author":"Furia","year":"2020","journal-title":"Ann. Thorac. Surg."}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/6\/237\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:07Z","timestamp":1760146087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/8\/6\/237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["tomography8060237"],"URL":"https:\/\/doi.org\/10.3390\/tomography8060237","relation":{},"ISSN":["2379-139X"],"issn-type":[{"value":"2379-139X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,28]]}}}