{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:28:27Z","timestamp":1760149707330,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cno-profit support\u201d from industrial sponsorships (Chiesi Farmaceutici S.p.A. and Bayer)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tomography"],"abstract":"<jats:p>Background. The E-MIOT (Extension-Myocardial Iron Overload in Thalassemia) project is an Italian Network assuring high-quality quantification of tissue iron overload by magnetic resonance imaging (MRI). We evaluated the impact of the COVID-19 pandemic on E-MIOT services. Methods. The activity of the E-MIOT Network MRI centers in the year 2020 was compared with that of 2019. A survey evaluated whether the availability of MRI slots for patients with hemoglobinopathies was reduced and why. Results. The total number of MRI scans was 656 in 2019 and 350 in 2020, with an overall decline of 46.4% (first MRI: 71.7%, follow-up MRI: 36.9%), a marked decline (86.9%) in the period March\u2013June 2020, and a reduction in the gap between the two years in the period July\u2013September. A new drop (41.4%) was recorded in the period October\u2013December for two centers, due to the general reduction in the total amount of MRIs\/day for sanitization procedures. In some centers, patients refused MRI scans for fear of getting COVID. Drops in the MRI services &gt;80% were found for patients coming from a region without an active MRI site. Conclusions. The COVID-19 pandemic had a strong negative impact on MRI multi-organ iron quantification, with a worsening in the management of patients with hemoglobinopathies.<\/jats:p>","DOI":"10.3390\/tomography9050136","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:42:49Z","timestamp":1694428969000},"page":"1711-1722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of the COVID-19 Pandemic on Iron Overload Assessment by MRI in Patients with Hemoglobinopathies: The E-MIOT Network Experience"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-8585","authenticated-orcid":false,"given":"Antonella","family":"Meloni","sequence":"first","affiliation":[{"name":"Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy"},{"name":"Unit\u00e0 Operativa Complessa Bioingegneria, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0743-9214","authenticated-orcid":false,"given":"Amalia","family":"Lupi","sequence":"additional","affiliation":[{"name":"Istituto di Radiologia, Dipartimento di Medicina, Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Righi","sequence":"additional","affiliation":[{"name":"Diagnostica per Immagini e Radiologia Interventistica, Ospedale del Delta, 44023 Lagosanto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Vallone","sequence":"additional","affiliation":[{"name":"Reparto di Radiologia, Azienda Ospedaliera \u201cGaribaldi\u201d Presidio Ospedaliero Nesima, 95126 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Missere","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Radiodiagnostica, Gemelli Molise SpA, Fondazione di Ricerca e Cura \u201cGiovanni Paolo II\u201d, 86100 Campobasso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Renne","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Cardioradiologia, Presidio Ospedaliero \u201cGiovanni Paolo II\u201d, 88046 Lamezia Terme, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Fina","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa Diagnostica per Immagini, Ospedale \u201cSandro Pertini\u201d, 00157 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Riva","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Radiologia, Ospedale \u201cSS. Annunziata\u201d ASL Taranto, 74121 Taranto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Gamberini","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Day Hospital della Talassemia e delle Emoglobinopatie, Dipartimento della Riproduzione e dell\u2019Accrescimento, Azienda Ospedaliero-Universitaria \u201cS. Anna\u201d, 44124 Cona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Cecinati","sequence":"additional","affiliation":[{"name":"Struttura Semplice di Microcitemia, Ospedale \u201cSS. Annunziata\u201d ASL Taranto, 74100 Taranto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Semplice Dipartimentale Day Hospital Talassemici, Ospedale \u201cSant\u2019Eugenio\u201d, 00143 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosamaria","family":"Rosso","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Talassemie ed Emoglobinopatie, Azienda Ospedaliero-Universitaria Policlinico \u201cVittorio Emanuele\u201d, 95100 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Messina","sequence":"additional","affiliation":[{"name":"Centro Microcitemie, Grande Ospedale Metropolitano \u201cBianchi-Melacrino-Morelli\u201d, 89100 Reggio Calabria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-3308","authenticated-orcid":false,"given":"Paolo","family":"Ricchi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Semplice Dipartimentale Malattie Rare del Globulo Rosso, Azienda Ospedaliera di Rilievo Nazionale \u201cA. Cardarelli\u201d, 80131 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-9572","authenticated-orcid":false,"given":"Vincenzo","family":"Positano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy"},{"name":"Unit\u00e0 Operativa Complessa Bioingegneria, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-7766","authenticated-orcid":false,"given":"Sophie","family":"Mavrogeni","sequence":"additional","affiliation":[{"name":"Onassis Cardiac Surgery Center, 17674 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-9365","authenticated-orcid":false,"given":"Emilio","family":"Quaia","sequence":"additional","affiliation":[{"name":"Istituto di Radiologia, Dipartimento di Medicina, Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-3279","authenticated-orcid":false,"given":"Filippo","family":"Cademartiri","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione G. Monasterio CNR-Regione Toscana, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-3829","authenticated-orcid":false,"given":"Alessia","family":"Pepe","sequence":"additional","affiliation":[{"name":"Istituto di Radiologia, Dipartimento di Medicina, Universit\u00e0 di Padova, 35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/bmj.314.7095.1675","article-title":"The thalassaemias","volume":"314","author":"Weatherall","year":"1997","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1056\/NEJM199709113371107","article-title":"Pathogenesis and treatment of sickle cell disease","volume":"337","author":"Bunn","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1182\/blood-2010-01-251348","article-title":"The inherited diseases of hemoglobin are an emerging global health burden","volume":"115","author":"Weatherall","year":"2010","journal-title":"Blood"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/gim.2016.173","article-title":"Beta-Thalassemia","volume":"19","author":"Origa","year":"2017","journal-title":"Genet. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bou-Fakhredin, R., Bazarbachi, A.H., Chaya, B., Sleiman, J., Cappellini, M.D., and Taher, A.T. (2017). Iron Overload and Chelation Therapy in Non-Transfusion Dependent Thalassemia. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122778"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1067\/mpd.2001.119593","article-title":"Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia","volume":"139","author":"Miller","year":"2001","journal-title":"J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1056\/NEJM200006223422502","article-title":"Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group","volume":"342","author":"Vichinsky","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJMra050436","article-title":"Beta-thalassemia","volume":"353","author":"Rund","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"358283","DOI":"10.1155\/2010\/358283","article-title":"Iron Loading and Overloading due to Ineffective Erythropoiesis","volume":"2010","author":"Tanno","year":"2010","journal-title":"Adv. Hematol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1182\/blood.V100.1.17","article-title":"Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation","volume":"100","author":"Angelucci","year":"2002","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/JBM.S186362","article-title":"Thalassemia and hepatocellular carcinoma: Links and risks","volume":"10","author":"Marsella","year":"2019","journal-title":"J. Blood Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1749-6632.2010.05545.x","article-title":"Predicting pituitary iron and endocrine dysfunction","volume":"1202","author":"Wood","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_13","first-page":"e2009003","article-title":"Thalassaemia and aberrations of growth and puberty","volume":"1","author":"Kyriakou","year":"2009","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ajh.22223","article-title":"Pancreatic iron and glucose dysregulation in thalassemia major","volume":"87","author":"Noetzli","year":"2012","journal-title":"Am. J. Hematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ajh.22247","article-title":"Pituitary iron and volume predict hypogonadism in transfusional iron overload","volume":"87","author":"Noetzli","year":"2012","journal-title":"Am. J. Hematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.2337\/dc20-0908","article-title":"The Close Link of Pancreatic Iron with Glucose Metabolism and with Cardiac Complications in Thalassemia Major: A Large, Multicenter Observational Study","volume":"43","author":"Pepe","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1196\/annals.1345.047","article-title":"Physiology and pathophysiology of iron cardiomyopathy in thalassemia","volume":"1054","author":"Wood","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.ijcard.2014.09.139","article-title":"Different patterns of myocardial iron distribution by whole-heart T2* magnetic resonance as risk markers for heart complications in thalassemia major","volume":"177","author":"Meloni","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1532-429X-10-42","article-title":"Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonance","volume":"10","author":"Modell","year":"2008","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1093\/eurheartj\/ehab851","article-title":"National networking in rare diseases and reduction of cardiac burden in thalassemia major","volume":"43","author":"Pepe","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/bjh.14575","article-title":"How we manage iron overload in sickle cell patients","volume":"177","author":"Coates","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/bjh.15595","article-title":"MRI multicentre prospective survey in thalassaemia major patients treated with deferasirox versus deferiprone and desferrioxamine","volume":"183","author":"Pepe","year":"2018","journal-title":"Br. J. Haematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s00417-020-04858-7","article-title":"Impact of COVID-19 on outpatient visits and intravitreal treatments in a referral retina unit: Let\u2019s be ready for a plausible \u201crebound effect\u201d","volume":"258","author":"Borrelli","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s40123-020-00251-z","article-title":"Protect Healthcare Workers and Patients from COVID-19: The Experience of Two Tertiary Ophthalmology Care Referral Centers in Italy","volume":"9","author":"Parravano","year":"2020","journal-title":"Ophthalmol. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"588852","DOI":"10.3389\/fpubh.2020.588852","article-title":"Consequences of COVID-19 Outbreak in Italy: Medical Responsibilities and Governmental Measures","volume":"8","author":"Ricci","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(20)30627-9","article-title":"COVID-19 and Italy: What next?","volume":"395","author":"Remuzzi","year":"2020","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jmri.21781","article-title":"Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron","volume":"30","author":"Ramazzotti","year":"2009","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1007\/s00330-018-5783-6","article-title":"Multicenter validation of the magnetic resonance T2* technique for quantification of pancreatic iron","volume":"29","author":"Meloni","year":"2019","journal-title":"Eur. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.mri.2008.06.004","article-title":"Improved T2* assessment in liver iron overload by magnetic resonance imaging","volume":"27","author":"Positano","year":"2009","journal-title":"Magn. Reson. Imaging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/mrm.22640","article-title":"Regional and global pancreatic T*(2) MRI for iron overload assessment in a large cohort of healthy subjects: Normal values and correlation with age and gender","volume":"65","author":"Restaino","year":"2011","journal-title":"Magn. Reson. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jmri.20566","article-title":"Multislice multiecho T2* cardiovascular magnetic resonance for detection of the heterogeneous distribution of myocardial iron overload","volume":"23","author":"Pepe","year":"2006","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/mrm.22410","article-title":"Preferential patterns of myocardial iron overload by multislice multiecho T*2 CMR in thalassemia major patients","volume":"64","author":"Meloni","year":"2010","journal-title":"Magn. Reson. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/nbm.1121","article-title":"Standardized T2* map of normal human heart in vivo to correct T2* segmental artefacts","volume":"20","author":"Positano","year":"2007","journal-title":"NMR Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jmri.22417","article-title":"Single region of interest versus multislice T2* MRI approach for the quantification of hepatic iron overload","volume":"33","author":"Meloni","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/bjh.12296","article-title":"The use of appropriate calibration curves corrects for systematic differences in liver R2* values measured using different software packages","volume":"161","author":"Meloni","year":"2013","journal-title":"Br. J. Haematol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2004-10-3982","article-title":"MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients","volume":"106","author":"Wood","year":"2005","journal-title":"Blood"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1007\/s00261-015-0522-9","article-title":"Accurate estimate of pancreatic T2* values: How to deal with fat infiltration","volume":"40","author":"Meloni","year":"2015","journal-title":"Abdom. Imaging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJM200008033430503","article-title":"Hepatic iron concentration and total body iron stores in thalassemia major","volume":"343","author":"Angelucci","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","article-title":"Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload","volume":"22","author":"Anderson","year":"2001","journal-title":"Eur. Heart J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e001359","DOI":"10.1136\/openhrt-2020-001359","article-title":"The impact of the COVID-19 pandemic on cardiology services","volume":"7","author":"Fersia","year":"2020","journal-title":"Open Heart"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"103080","DOI":"10.1016\/j.transci.2021.103080","article-title":"People with blood disorders can be more vulnerable during COVID-19 pandemic: A hypothesis paper","volume":"60","author":"Aydemir","year":"2021","journal-title":"Transfus. Apher. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1111\/bjh.16911","article-title":"Prevalence and mortality in beta-thalassaemias due to outbreak of novel coronavirus disease (COVID-19): The nationwide Iranian experience","volume":"190","author":"Karimi","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"E198","DOI":"10.1002\/ajh.25840","article-title":"SARS-CoV-2 infection in beta thalassemia: Preliminary data from the Italian experience","volume":"95","author":"Motta","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/bloodadvances.2020003456","article-title":"Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection","volume":"5","author":"Minniti","year":"2021","journal-title":"Blood Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/CIR.0b013e31829b2be6","article-title":"Cardiovascular function and treatment in beta-thalassemia major: A consensus statement from the American Heart Association","volume":"128","author":"Pennell","year":"2013","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/ehjci\/jeu191","article-title":"Improvement of heart iron with preserved patterns of iron store by CMR-guided chelation therapy","volume":"16","author":"Meloni","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"}],"container-title":["Tomography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2379-139X\/9\/5\/136\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:48:33Z","timestamp":1760129313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2379-139X\/9\/5\/136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["tomography9050136"],"URL":"https:\/\/doi.org\/10.3390\/tomography9050136","relation":{},"ISSN":["2379-139X"],"issn-type":[{"type":"electronic","value":"2379-139X"}],"subject":[],"published":{"date-parts":[[2023,9,11]]}}}